{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:34Z","timestamp":1772168854701,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.135076.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000}}],"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : Tuberculosis is a chronic infectious disease and can be categorised into pulmonary TB and extra-pulmonary TB based on its spread. TB lymphadenitis is one of the extra-pulmonary TB diseases. Patients with a weakened immune system in systemic lupus erythematosus (SLE) have an increased incidence of TB.\n                    <ns4:bold>Case<\/ns4:bold>\n                    : Here we present a case report of a 21-year-old female patient with SLE diagnosed with tuberculous lymphadenitis at dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. The patient complained of a lump in the right neck 4 months ago with a diameter of 4 cm, accompanied by fever, decreased appetite, and weight loss. Other than that, the patient also experiences joint pain, hair loss and sun sensitivity since 12 months ago. Chest radiography showed no abnormalities, and fine-needle aspiration biopsy results confirmed tuberculous lymphadenitis. Antinuclear antibody test was borderline. The patient had been taking steroids and hydroxychloroquine for the past 10 months. Currently, the patient is taking the advanced phase of antituberculosis drugs FDC. After undergoing the intensive phase of antituberculosis drugs, the submandibular lump got smaller to a diameter of 2 cm.\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : TB lymphadenitis is a rare case but can occur in conditions of decreased immunity like SLE. It involves some of the immune disorders caused by the long-term use of immunosuppressive therapy.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.135076.2","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:05:50Z","timestamp":1697436350000},"page":"763","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Tuberculosis lymphadenitis with systemic lupus erythematosus in a young woman: a case report"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1950-4025","authenticated-orcid":false,"given":"Yunita","family":"Arliny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewi Behtri","family":"Yanifitri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilia Aprilisa","family":"Utami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Geraldine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"OR01-OR03","DOI":"10.7860\/JCDR\/2017\/22749.9398","article-title":"SLE and Tuberculosis: A Case Series and Review of Literature.","volume":"11","author":"P Bhattacharya","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref3","article-title":"Global Tuberculosis Report 2022.","year":"2022"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.18203\/2349-2902.isj20190407","article-title":"A clinical study of tuberculous cervical lymphadenopathy: surgeon\u2019s perspectives.","volume":"6","author":"K Patel","year":"2019 Jan 28","journal-title":"Int. Surg. J."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.20473\/jr.v1-I.3.2015.81-87","article-title":"Primary Multidrug-Resistant Tuberculosis Mixed with Lymphadenitis Tuberculosis in a Woman with SLE.","volume":"1","author":"I Sari","year":"2019 Apr 1","journal-title":"J. Respirasi."},{"key":"ref7","article-title":"Cervical Lymphadenopathy: A Common Diagnostic Dilemma.","author":"S Qasmi","year":"2012"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"95-100","DOI":"10.55816\/mpi.v29i2.419","article-title":"Analysis Morphological of Tuberculosis Lymphadenitis Features between Cytology Biopsy of Fine Needle Aspiration Polymerase Chain Reaction Methods.","volume":"29","author":"D Suryadi","year":"2020 May 1","journal-title":"Maj. Patol. Indones."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1-13","DOI":"10.1016\/j.jaut.2018.11.001","article-title":"Systemic lupus erythematosus: Diagnosis and clinical management.","volume":"96","author":"A Fava","year":"2019 Jan","journal-title":"J. Autoimmun."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"244","DOI":"10.4103\/0022-3859.68653","article-title":"Systemic lupus erythematosus and tuberculosis: A review of complex interactions of complicated diseases.","volume":"56","author":"S Agrawal","year":"2010","journal-title":"J. Postgrad. Med."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac201","article-title":"Tuberculosis Among Patients With Systemic Lupus Erythematosus in Indonesia: A Cohort Study. Open Forum.","volume":"9","author":"L Hamijoyo","year":"2022 Jul 4","journal-title":"Infect. Dis."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"181-191","DOI":"10.1007\/s10067-020-05225-x","article-title":"Factors associated with active tuberculosis in Colombian patients with systemic lupus erythematosus: a case-control study.","volume":"40","author":"L Gonz\u00e1lez-Naranjo","year":"2021 Jan 11","journal-title":"Clin. Rheumatol."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1819-1827","DOI":"10.1177\/0961203318792352","article-title":"Corticosteroid dose and the risk of opportunistic infection in a national systemic lupus erythematosus cohort.","volume":"27","author":"S Yang","year":"2018 Oct 13","journal-title":"Lupus."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.26410","article-title":"Predisposing Factors of Tuberculosis Infection in Systemic Lupus Erythematosus Patients: A Single-Center Case-Control Study.","author":"I Damara","year":"2022 Jun 28","journal-title":"Cureus."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"47-55","DOI":"10.4046\/trd.2015.78.2.47","article-title":"Diagnosis and Treatment of Extrapulmonary Tuberculosis.","volume":"78","author":"J Lee","year":"2015","journal-title":"Tuberc. Respir. Dis (Seoul)."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"30-48","DOI":"10.1038\/s41584-018-0133-2","article-title":"New therapeutic strategies in systemic lupus erythematosus management.","volume":"15","author":"M Gatto","year":"2019 Jan 11","journal-title":"Nat. Rev. Rheumatol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-763\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-763\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-763\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T06:25:21Z","timestamp":1699856721000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-763\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":14,"URL":"https:\/\/doi.org\/10.12688\/f1000research.135076.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.157467.r215698","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.157467.r215699","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.157467.r215698","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.157467.r215699","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,16]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-763\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.157467.r215699, PB Sryma, Department of Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 13 Nov 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-763\/v2#referee-response-215699","order":0,"name":"referee-response-215699","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.157467.r215698, Gyanshankar Mishra, Indira Gandhi Government Medical College, Nagpur, Maharashtra, 31 Oct 2023, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-763\/v2#referee-response-215698","order":1,"name":"referee-response-215698","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.148177.r205699, Henna Iqbal, Mercer University School of Medicine, Macon, GA, 31 Oct 2023, version 1, 2 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/12-763\/v1#referee-response-205699","order":2,"name":"referee-response-205699","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Yunita Arliny <\/b>; \n<i>Posted: 31 Oct 2023<\/i>; Dear Reviewer, Thank you for your review.&nbsp;  Here we present you the clarification based on guidelines from the Indonesian Ministry of Health about the diagnostic of TB Lymphadenopathy.  \u201cTuberculosis lymphadenopathy can affect all ages, especially at the age of 10-30 years, more often in women. Constitutional symptoms occur in 33-85% of patients. Diagnosis is made through needle aspiration smooth or gland biopsy. Preparations from fine needle aspiration or Biopsy can reveal caseous granulomatous inflammation with cells Datia Langhans. The diagnosis can ALSO be confirmed through the TB rapid molecular test.\u201d  So, needle aspiration can be a diagnostic method as in our article with or without molecular tests to confirm the diagnostic.  If you have any other suggestions, please don\u2019t hesitate.  Thank you. Regards, Yunita Arliny","URL":"https:\/\/f1000research.com\/articles\/12-763\/v2#referee-comment-10491","order":3,"name":"referee-comment-10491","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}