{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:21:31Z","timestamp":1784823691734,"version":"3.55.0"},"update-to":[{"DOI":"10.12688\/f1000research.135154.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000}},{"DOI":"10.12688\/f1000research.135154.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000}}],"reference-count":8,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T00:00:00Z","timestamp":1699401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Apocrine carcinoma is an extremely rare malignant cutaneous neoplasm that usually arises in areas with a high density of apocrine glands. Diagnosis can be challenging as tumours share histological and immunophenotypic characteristics with them. At first evaluation, the disease is often assumed to be benign.\u00a0There have been approximately 100 reports of apocrine neoplasms in the literature. A 48-year-old male presented with a right axillary mass which increased in size over a period of 2 years. The patient was reported to have had ayurvedic therapy, but his swelling remained unchanged. Axillary lymph nodes were palpable. USG axilla suggested a well-defined fungating solid isoechoic lesion. USG neck did not reveal any abnormality. The mass was surgically excised as a whole by removing the overlying skin with margins and lymph node excision. The patient was diagnosed with primary apocrine carcinoma after surgical excision. The differentials include adenocarcinoma of breast and prostate and apocrine adenoma. There are no established standards for the care of this form of carcinoma due to its rarity and the absence of clinical studies. A literature evaluation and further reporting will aid in developing diagnostic standards and the most efficient treatment options.<\/ns3:p>","DOI":"10.12688\/f1000research.135154.3","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T06:10:07Z","timestamp":1699423807000},"page":"803","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: A Pathological Odyssey in Primary Cutaneous Apocrine Carcinoma"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-6954","authenticated-orcid":false,"given":"Dr. Suhit","family":"Naseri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samarth","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dr. Sourya","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunita","family":"Vagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,11,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"682-690","DOI":"10.1097\/PAS.0b013e3181590ba4","article-title":"Primary cutaneous apocrine carcinoma: a clinico-pathologic analysis of 24 cases.","volume":"32","author":"A Robson","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"468-470","DOI":"10.1111\/j.1524-4725.1990.tb00066.x","article-title":"Apocrine adenocarcinoma: case report and review of the literature.","volume":"16","author":"S Dhawan","year":"1990","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"566-572","DOI":"10.1002\/1097-0142(19820801)50:3<566::aid-cncr2820500330>3.0.co;2-q","article-title":"Microcystic adnexal carcinoma: a distinct clinicopathologic entity.","volume":"50","author":"D Goldstein","year":"1982","journal-title":"Cancer."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"415-419","DOI":"10.1002\/jso.22023","article-title":"Cutaneous apocrine adenocarcinoma: defining epidemiology, outcomes, and optimal therapy for a rare neoplasm.","volume":"105","author":"K Hollowell","year":"2012","journal-title":"J. Surg. Oncol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"131-135","DOI":"10.1097\/00000421-199904000-00005","article-title":"Apocrine gland carcinoma of the axilla: review of the literature and recommendations for treatment.","volume":"22","author":"R Chamberlain","year":"1999","journal-title":"Am. J. Clin. Oncol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"23-29","DOI":"10.1002\/jso.2930080104","article-title":"Sweat gland carcinoma: a clinico-pathological reappraisal.","volume":"8","author":"D Mitts","year":"1976","journal-title":"J. Surg. Oncol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"757-761","DOI":"10.1136\/jcp.2004.019794","article-title":"Axillary apocrine carcinoma with benign apocrine tumours: a case report involving a pathological and immunohistochemical study and review of the literature.","volume":"58","author":"T Miyamoto","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"145-159","DOI":"10.1136\/jcp.2006.041608","article-title":"Skin adnexal neoplasms\u2014part 2: an approach to tumours of cutaneous sweat glands.","volume":"60","author":"N Obaidat","year":"2007","journal-title":"J. Clin. Pathol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-803\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-803\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-803\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T23:30:09Z","timestamp":1718235009000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-803\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,8]]},"references-count":8,"URL":"https:\/\/doi.org\/10.12688\/f1000research.135154.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.135154.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.135154.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.158522.r271478","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.158522.r221655","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.158522.r271478","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.158522.r221655","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,8]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-803\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.158522.r221655, Rehan Zahid, Plastic Surgery, The University of Iowa Healthcare, Iowa City, IA, 30 Nov 2023, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/12-803\/v3#referee-response-221655","order":0,"name":"referee-response-221655","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.156396.r202439, Nour Kibbi, Stanford University School of Medicine, Palo Alto, California, 03 Oct 2023, version 2, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-803\/v2#referee-response-202439","order":1,"name":"referee-response-202439","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Dr. Suhit Naseri<\/b>; \n<i>Posted: 03 Nov 2023<\/i>; \n<i>The authors should rename this as a primary cutaneous apocrine carcinoma since an invasive ductal breast carcinoma could not be found.<\/i> - Modification of the title is done.  \n<i>The novelty of the case is not entirely clear and the authors might consider completing a literature review to determine what this case adds to the existing literature on this rare tumor.&nbsp;<\/i> - Inclusion of further literature has been done.&nbsp;  \n<i>Regarding language, the report is a bit wordy at times and would benefit from further editing for brevity and consistency.<\/i> - The required language corrections have been implemented.  \n<i>&nbsp;The histopathological images provided are not of adequate quality and would benefit from retaking with a camera attached to the microscope.<\/i> -&nbsp;Regrettably, due to the unavailability of the necessary resources, it is not feasible to retake the images.  \n<i>There are abbreviations used without being spelled out, such as USG. It is also not clear what a Tru Cut biopsy is. The surgical margin is indicated as a range and it is not clear why.<\/i> -&nbsp;Proper placement of abbreviations. -&nbsp;A Tru-Cut, also known as a Tru-Cut biopsy, is a medical procedure used to obtain a small core of tissue from a specific area of the body for diagnostic purposes. -&nbsp;The surgical margin is expressed as a range to account for variations in tumor size and shape.","URL":"https:\/\/f1000research.com\/articles\/12-803\/v3#referee-comment-10517","order":2,"name":"referee-comment-10517","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.158522.r271478, Dr. Ashwinkumar Barsagade, Andaman and Nicobar Islands Institute of Medical sciences, Port Blair, 13 Jun 2024, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/12-803\/v3#referee-response-271478","order":3,"name":"referee-response-271478","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}