{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:59:15Z","timestamp":1776653955498,"version":"3.51.2"},"reference-count":33,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["HRC-9409"],"award-info":[{"award-number":["HRC-9409"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background<\/ns4:bold>\n                    : Transcranial Direct Current Stimulation (tDCS) is reportedly a potential treatment option for chronic tinnitus. The main drawbacks of previous studies are short term follow up and focusing on the efficacy of single session tDCS. This study aims to investigate the therapeutic efficacy, adverse effects (AEs) and tolerability of repeated sessions of bilateral tDCS over auditory cortex (AC) on tinnitus symptoms\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods<\/ns4:bold>\n                    : This will be a double-blinded randomized placebo controlled parallel trial on patients (n=90) with intractable chronic tinnitus (&gt; 2 years) randomly divided into three groups of anodal, cathodal, and sham tDCS. In the sham treatment, after 30 sec the device will be turned OFF without informing the patients. The tDCS protocol consists of 10 sessions (daily \u00a020 min session; 2 mA current for 5 consecutive days per week and 2 consecutive weeks) applied through 35 cm\n                    <ns4:sup>2<\/ns4:sup>\n                    electrodes. The primary outcome is tinnitus handicap inventory (THI) which will be assessed pre- and post-intervention and at one month follow-up. The secondary outcomes are tinnitus loudness and distress to be assessed using a visual analogue scale (VAS) pre-intervention, and immediately, one hour, one week, and one month after last stimulation. The AEs and tolerability of patients will be evaluated after each session using a customized questionnaire. Possible interactions between the disease features and treatment response will be evaluated. \u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Discussion<\/ns4:bold>\n                    : To our knowledge this is the first study to investigate the effects of repeated sessions of tDCS on chronic tinnitus symptoms with one month follow-up. In addition, the AEs, and tolerability of patients will be studied. In addition, the possible interactions between the disease specific features including the hearing loss, laterality, type of tinnitus, and treatment response will be evaluated. \u00a0\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Trial registration<\/ns4:bold>\n                    : The study has been registered as a clinical trial in Iranian Registry of Clinical Trial (\n                    <ns4:ext-link xmlns:ns3=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" ns3:href=\"http:\/\/en.irct.ir\/trial\/20770\">IRCT2016110124635N6<\/ns4:ext-link>\n                    ) on the 01\/06\/2017.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.13558.1","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T05:05:06Z","timestamp":1521003906000},"page":"317","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Repeated sessions of bilateral transcranial direct current stimulation on intractable tinnitus: a study protocol for a double-blind randomized controlled 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.14726.r31942, Leonid S. Godlevsky, Ministry of Public Health, Odessa National Medical University, Odessa, Ukraine, 23 Mar 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-317\/v1#referee-response-31942","order":0,"name":"referee-response-31942","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.14726.r32356, Daniel Robles-Camarillo, Graduate and Research Department, Polytechnic University of Pachuca, Zempoala, Hidalgo, Mexico, 04 Apr 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-317\/v1#referee-response-32356","order":1,"name":"referee-response-32356","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study is financially supported by Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran (Grant No: HRC-9409). The AJUMS has no role in the design of the study, collection of data, analyses, and interpretation of data as well as in composing the manuscript. It, as the external funding body has reviewed the study in a double blinding peer review policy and it was approved by the editorial board member of the University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}