{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:16:28Z","timestamp":1778915788925,"version":"3.51.4"},"reference-count":52,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["109031\/Z15\/Z"],"award-info":[{"award-number":["109031\/Z15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["104992\/Z\/14\/Z"],"award-info":[{"award-number":["104992\/Z\/14\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Bacterial meningitis remains an important cause of global morbidity and mortality. Although effective vaccinations exist and are being increasingly used worldwide, bacterial diversity threatens their impact and the ultimate goal of eliminating the disease. Through genomic epidemiology, we can appreciate bacterial population structure and its consequences for transmission dynamics, virulence, antimicrobial resistance, and development of new vaccines. Here, we review what we have learned through genomic epidemiological studies, following the rapid implementation of whole genome sequencing that can help to optimise preventative strategies for bacterial meningitis.<\/ns4:p>","DOI":"10.12688\/f1000research.13793.1","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T10:40:12Z","timestamp":1522147212000},"page":"401","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["A world without bacterial meningitis: how genomic epidemiology can inform vaccination strategy"],"prefix":"10.12688","volume":"7","author":[{"given":"Charlene M.C.","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6321-5138","authenticated-orcid":false,"given":"Martin C.J.","family":"Maiden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"282-8","DOI":"10.1097\/WCO.0b013e328360415c","article-title":"Update on bacterial meningitis: epidemiology, trials and genetic association studies.","volume":"26","author":"E Kasanmoentalib","year":"2013","journal-title":"Curr Opin Neurol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"430-40","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic analysis.","volume":"385","author":"L Liu","year":"2015","journal-title":"Lancet."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"117-71","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.14994.r32269, Pavla K\u0159\u00ed\u017eov\u00e1, National Institute of Public Health, Prague, Czech Republic, 27 Mar 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-401\/v1#referee-response-32269","order":0,"name":"referee-response-32269","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.14994.r32268, Thomas Benfield, Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark, 27 Mar 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-401\/v1#referee-response-32268","order":1,"name":"referee-response-32268","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The authors declare that this work was supported by the Wellcome Trust (grant 109031\/Z15\/Z to CMCR and grant 104992\/Z\/14\/Z to MCJM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}