{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:25Z","timestamp":1772168905459,"version":"3.50.1"},"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Wilms tumor (WT) is the most common renal malignancy seen in pediatric patients. Although lungs are the most common site of metastasis in Wilms tumor, non-malignant pleural effusion has been infrequently reported. Here, we report a case of an eleven-year-old female who presented with an abdominal mass and progressive breathlessness. On further evaluation, she was found to have a right-sided Wilms tumor with ipsilateral massive pleural effusion. The effusion resolved almost completely after four weeks of chemotherapy. We conclude that patients suffering from Wilms tumor presenting with pleural effusion need not be synonymous with metastatic disease and can have a favorable prognosis.<\/ns3:p>","DOI":"10.12688\/f1000research.138794.1","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T07:50:09Z","timestamp":1693381809000},"page":"1056","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Pleural effusion in Wilms tumor \u2013 always malignant?"],"prefix":"10.12688","volume":"12","author":[{"given":"Keta","family":"Vagha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patel","family":"Zeeshan Jameel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayant","family":"Vagha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish R.","family":"Varma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupesh","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2103-2114","DOI":"10.1016\/j.ejca.2006.05.010","article-title":"Malignant renal tumours incidence and survival in European children (1978\u20131997): report from the Automated Childhood Cancer Information System project.","volume":"42","author":"G Pastore","year":"2006 Sep 1","journal-title":"Eur. J. Cancer."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"37-46","DOI":"10.1016\/j.ejca.2019.04.008","article-title":"Wilms tumour event-free and overall survival in Southern and Eastern Europe: Pooled analyses of clinical data from four childhood cancer registries (1999\u20132017).","volume":"115","author":"D Doganis","year":"2019 Jul 1","journal-title":"Eur. J. Cancer."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"328-330","DOI":"10.1542\/pir.34.7.328","article-title":"Wilms tumor.","volume":"34","author":"A Friedman","year":"2013 Jul 1","journal-title":"Pediatr. Rev."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"145-148","DOI":"10.1002\/pbc.10429","article-title":"Significance of pleural effusion at diagnosis of Wilms tumor.","volume":"42","author":"B Corey","year":"2004 Feb","journal-title":"Pediatr. Blood Cancer."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"523-525","DOI":"10.1016\/0022-3468(77)90190-7","article-title":"Pleural effusion in Wilms\u2019 tumor.","volume":"12","author":"U Betkerur","year":"1977 Aug 1","journal-title":"J. Pediatr. Surg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"555-558","DOI":"10.1080\/08880010701534114","article-title":"Pleural effusion in wilms tumor after tru-cut biopsy.","volume":"24","author":"S K\u00fcpeli","year":"2007 Jan 1","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2333794X2095229","DOI":"10.1177\/2333794X20952292","article-title":"Wilms Tumor with Pleural Metastasis. Global.","volume":"7","author":"A Al-Hadidi","year":"2020 Aug","journal-title":"Pediatr. Health."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"274-277","DOI":"10.1002\/mpo.2950240413","article-title":"Wilms\u2019 tumor: cure of malignant pleural effusion exclusively with chemotherapy.","volume":"24","author":"C Canpolat","year":"1995 Apr","journal-title":"Med. Pediatr. Oncol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"621-625","DOI":"10.1002\/dc.20535","article-title":"Cytological identification of metastatic epithelial nephroblastoma in pleural fluid: report of a case and review of literature.","volume":"34","author":"M Schinstine","year":"2006 Sep","journal-title":"Diagn. Cytopathol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"467-473","DOI":"10.1159\/000332540","article-title":"Cytology of pleural, peritoneal and pericardial fluids in children. A 40-year summary.","volume":"41","author":"J Wong","year":"1997 Mar 1","journal-title":"Acta Cytol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:25:20Z","timestamp":1721625920000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":10,"URL":"https:\/\/doi.org\/10.12688\/f1000research.138794.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.152024.r246039","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.152024.r202399","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.152024.r202399","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.152024.r246039","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.152024.r246039, Marcello Della Corte, Erica Clemente, University of Turin, Orbassano, 07 Mar 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1#referee-response-246039","order":0,"name":"referee-response-246039","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Keta Vagha<\/b>; \n<i>Posted: 07 Mar 2024<\/i>; I am extremely grateful for your positive comments. I shall make the corrections advised by you and resubmit the manuscript.","URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1#referee-comment-11221","order":1,"name":"referee-comment-11221","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.152024.r202399, Keerti Swarnakar, Department\u00a0of\u00a0Pediatrics, All India Institute of Medical Sciences, Bhopal, Madhya\u00a0Pradesh, 22 Jul 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1056\/v1#referee-response-202399","order":2,"name":"referee-response-202399","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}