{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:06:20Z","timestamp":1785305180559,"version":"3.55.0"},"reference-count":33,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Portal hypertension is one of the most frequent complications of cirrhosis. \u03b2-adrenergic blockers, with or without organic nitrates, are currently used as hypotensive agents. Statins such as simvastatin seem to be safe for patients with chronic liver diseases and exert multiple pleiotropic actions. This study aimed to assess PTH using Doppler ultrasound in patients with cirrhosis before and after simvastatin administration.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    This randomized controlled clinical trial was conducted on 40 patients with cirrhosis who were randomized into 2 groups: group I included 20 patients with cirrhosis who were administered 20 mg of simvastatin daily for 2 weeks and then 40 mg daily for another 2 weeks, and group II included 20 patients with cirrhosis who did not receive simvastatin as a control group. All patients underwent full clinical examination, laboratory investigations, and abdominal Doppler ultrasound at baseline and after 30 days to evaluate portal vein diameter, blood flow volume, direction and velocity of portal vein blood flow, hepatic artery resistance and pulsatility indices, splenic artery resistance index, portal hypertension index (PHI), liver vascular index, and modified liver vascular index (MLVI).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    There was a highly significant decrease in the hepatic artery resistance index \u00a0in group I, from 0.785 \u00b1 0.088 to 0.717 \u00b1 0.086 (P &lt; 0.001). There was a significant decrease in the PHI in group I , from 3.915 \u00b1 0.973 m\/sec to 3.605 \u00b1 1.168 m\/sec (P = 0.024). Additionally, there was a significant increase in the MLVI in group I from 11.540 \u00b1 3.266 cm\/sec to 13.305 \u00b1 3.222 cm\/sec, an increase of 15.3% from baseline (P = 0.009). No significant adverse effects were detected.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Simvastatin is safe and effective in lowering portal hypertension.\n                  <\/ns4:p>\n                  <ns4:p>[ClinicalTrials.gov Identifier: NCT02994485]<\/ns4:p>","DOI":"10.12688\/f1000research.13915.1","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T10:31:20Z","timestamp":1519900280000},"page":"256","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of portal pressure by doppler ultrasound in patients with cirrhosis before and after simvastatin administration \u2013 a randomized controlled trial"],"prefix":"10.12688","volume":"7","author":[{"given":"Nadia","family":"Elwan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raafat","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal","family":"Hamisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtsam","family":"Shady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nehad","family":"Hawash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4366-2218","authenticated-orcid":false,"given":"Sherief","family":"Abd-Elsalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"573-582","DOI":"10.1038\/nrgastro.2009.149","article-title":"The clinical use of HVPG measurements in chronic liver disease.","volume":"6","author":"J Bosch","year":"2009","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1715-1728","DOI":"10.1053\/j.gastro.2008.03.007","article-title":"Portal hypertension and its complications.","volume":"134","author":"A Sanyal","year":"2008","journal-title":"Gastroenterology."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"S54-S68","DOI":"10.1016\/S0168-8278(02)00430-0","article-title":"Current management of portal hypertension.","volume":"38","author":"J Bosch","year":"2003","journal-title":"J Hepatol."},{"key":"ref-4","doi-asserted-by":"crossref","first-page":"270-275","DOI":"10.1111\/j.1432-2277.2003.tb00298.x","article-title":"Applicability of liver transplantation in Catalonia at the end of the millennium (A prospective study of adult patient selection for liver transplantation).","volume":"16","author":"V Vargas","year":"2003","journal-title":"Transpl Int."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"479-492","DOI":"10.1053\/gast.2000.9354","article-title":"Nitrovasodilators inhibit platelet-derived growth factor-induced proliferation and migration of activated human hepatic stellate cells.","volume":"119","author":"P Failli","year":"2000","journal-title":"Gastroenterology."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"741-748","DOI":"10.1172\/JCI7997","article-title":"Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension.","volume":"105","author":"Q Yu","year":"2000","journal-title":"J Clin Invest."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"440-445","DOI":"10.1136\/gut.51.3.440","article-title":"In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats.","volume":"51","author":"C Van de","year":"2002","journal-title":"Gut."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"522-531","DOI":"10.1016\/S0016-5085(03)00909-0","article-title":"Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats.","volume":"125","author":"M Morales-Ruiz","year":"2003","journal-title":"Gastroenterology."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"167-176","DOI":"10.1016\/j.jhep.2005.05.009","article-title":"Evolving consensus in portal hypertension. 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Department\u00a0of\u00a0Medicine, Khyber\u00a0Teaching\u00a0Hospital, Peshawar, Pakistan, 03 Apr 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-256\/v1#referee-response-31479","order":2,"name":"referee-response-31479","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}