{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:06:59Z","timestamp":1772168819635,"version":"3.50.1"},"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T00:00:00Z","timestamp":1695254400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Langerhans Cell Histiocytosis (LCH) is a typically benign disorder that affects infants predominately, with adult occurrence being uncommon. We discuss the case of a 22-year-old guy who visited our clinic complaining of three months of acute nape pain and upper limb radiculopathy. Notably, the patient had no history of trauma, fall injuries, or tuberculosis. Radiological tests identified a single osteolytic lesion within the C3 vertebral body. The lesion was removed, an anterior C3 corpectomy and discectomy were performed, and the patient's spine was reconstructed with a titanium cage and plating. The patient's nape discomfort and radiculopathy vanished almost instantly after surgery. A definitive diagnosis of LCH was confirmed through histological examination. This case report illustrates the unusual and uncommon occurrence of LCH at the C3 vertebral body, for which fusion surgery was the only viable therapeutic option. The patient's recovery from radiating pain following the surgical procedure demonstrates the effectiveness of the intervention. LCH in the cervical spine is rather rare, but it is nevertheless important to be aware of the possibility of developing it.<\/ns3:p>","DOI":"10.12688\/f1000research.139360.1","type":"journal-article","created":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T13:40:17Z","timestamp":1695303617000},"page":"1185","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Langerhans cell histiocytosis involving the cervical spine in an adult patient"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6428-8371","authenticated-orcid":false,"given":"Dipak","family":"Chaulagain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr","family":"Smolanka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andriy","family":"Smolanka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taras","family":"Havryliv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"615-618","DOI":"10.3324\/haematol.11827","article-title":"Neurodegenerative central nervous system disease as late sequelae of Langerhans cell histiocytosis. Report from the Japan LCH study group.","volume":"93","author":"S Imashuku","year":"2008","journal-title":"Haematologica."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1173-1178","DOI":"10.1093\/annonc\/mdp455","article-title":"MACOP-B regimen in the treatment of adult Langerhans cell histiocytosis: Experience on seven patients.","volume":"21","author":"E Derenzini","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"103-115","DOI":"10.1007\/s00247-004-1262-0","article-title":"Langerhans\u2019 cell histiocytosis: pathology, imaging and treatment of skeletal involvement.","volume":"35","author":"E Azouz","year":"2005","journal-title":"Pediatr. Radiol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"409-412","DOI":"10.5137\/1019-5149. JTN.1625-08.2","article-title":"Langerhans cell histiocytosis of the cervical spine in an adult: A case report.","volume":"2","author":"S Sayhan","year":"2010","journal-title":"Turk. Neurosurg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"242-249","DOI":"10.1515\/raon-2015-0024","article-title":"Central nervous system imaging in childhood Langerhans cell histiocytosis - a reference center analysis.","volume":"49","author":"L Porto","year":"2015","journal-title":"Radiol. Oncol."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1099-1105","DOI":"10.1177\/147323001003800338","article-title":"Clonal status and clinicopathological features of Langerhans cell histiocytosis.","volume":"38","author":"L Gong","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1919-1923","DOI":"10.1182\/blood-2010-04-279083","article-title":"Recurrent BRAF mutations in Langerhans cell histiocytosis.","volume":"116","author":"G Badalian-Very","year":"2010","journal-title":"Blood."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"458-460","DOI":"10.3340\/jkns.2010.47.6.458","article-title":"Langerhans cell histiocytosis causing cervical myelopathy in a child.","volume":"47","author":"K Jang","year":"2010","journal-title":"J. Korean Neurosurg. Soc."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"89-96","DOI":"10.1093\/qjmed\/hcq206","article-title":"Langerhans cell histiocytosis: old disease new treatment.","volume":"104","author":"B Ng-Cheng-Hin","year":"2011","journal-title":"QJM."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"409-412","DOI":"10.5137\/1019-5149.JTN.1625-08.2","article-title":"Langerhans cell histiocytosis of the cervical spine in an adult: a case report.","volume":"20","author":"S Sayhan","year":"2010","journal-title":"Turk. Neurosurg."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1099-1105","DOI":"10.1177\/147323001003800338","article-title":"Clonal status and clinicopathological features of Langerhans cell histiocytosis.","volume":"38","author":"L Gong","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"23-24","DOI":"10.1007\/s00586-009-1173-8","article-title":"Expert\u2019s comment concerning grand rounds case entitled \u201cLangerhans cell histiocytosis of the atlas in an adult\u201d (by Wo Quan Zhong, Liang Jiang, Qing Jun Ma, Zhong Jun Liu, Xiao Guang Liu, Feng Wei, Hui Shu Yuan, Geng Ting Dang).","volume":"19","author":"J Jouve","year":"2010","journal-title":"Eur. Spine J."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"441-S444","DOI":"10.1007\/s00586-011-2052-7","article-title":"Solitary eosinophilic granuloma of the adult lumbar spine.","volume":"21","author":"M Montalti","year":"2012","journal-title":"Eur. Spine J."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/1750-1172-8-72","article-title":"Management of adult patients with Langerhans cell histiocytosis: Recommendations from an expert panel on behalf of Euro-Histio-Net.","volume":"8","author":"M Girschikofsky","year":"2013","journal-title":"Orphanet J. Rare Dis."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T00:40:10Z","timestamp":1717807210000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,21]]},"references-count":14,"URL":"https:\/\/doi.org\/10.12688\/f1000research.139360.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.152631.r246281","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.152631.r240234","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.152631.r246281","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.152631.r240234","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.152631.r240234, Abhilash Thatikala, UAMS College of Medicine, Little Rock, Arkansas, 05 Feb 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1#referee-response-240234","order":0,"name":"referee-response-240234","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.152631.r246281, Mohammad Alfawareh, King Hussain Cancer Center, Amman, 08 Jun 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1185\/v1#referee-response-246281","order":1,"name":"referee-response-246281","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}