{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T02:44:24Z","timestamp":1775097864138,"version":"3.50.1"},"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Maynard Chair in Breast Cancer Epigenomics","award":["P30 CA023074"],"award-info":[{"award-number":["P30 CA023074"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"\n We have previously described a hominid-specific long non-coding RNA,\n MORT<\/ns4:italic>\n (also known as\n ZNF667-AS1<\/ns4:italic>\n , Gene ID:\n 100128252<\/ns4:ext-link>\n ), which is expressed in all normal cell types, but epigenetically silenced during cancer-associated immortalization of human mammary epithelial cells.\u00a0 Initial analysis of The Cancer Genome Atlas (TCGA) showed that 15 of 17 cancer types, which represent the 10 most common cancers in women and men, display DNA methylation associated\n MORT<\/ns4:italic>\n silencing in a large fraction of their tumors.\u00a0 In this study we analyzed\n MORT<\/ns4:italic>\n expression and DNA methylation state in the remaining 16 TCGA cancer types not previously reported.\u00a0 Seven of the 16 cancer types showed DNA methylation linked\n MORT<\/ns4:italic>\n silencing in a large fraction of their tumors. \u00a0These are carcinomas (cervical cancer, and cancers of esophagus, stomach, and bile duct), and the non-epithelial tumors mesothelioma, sarcoma, and uterine carcinosarcoma.\u00a0 Together with the findings from our previous report,\n MORT<\/ns4:italic>\n expression is silenced by aberrant DNA methylation in 22 of 33 of TCGA cancer types.\u00a0 These 22 cancers include most carcinoma types, blood derived cancers and sarcomas. \u00a0In conclusion, results suggest that the\n MORT<\/ns4:italic>\n gene is one of the most common epigenetic aberrations seen in human cancer.\u00a0 Coupled with the timing of\n MORT<\/ns4:italic>\n gene silencing during\n in vitro<\/ns4:italic>\n epithelial cell immortalization and its occurrence early in the temporal arc of human carcinogenesis, this provides strong circumstantial evidence for a tumor suppressor role for\n MORT<\/ns4:italic>\n .\n <\/ns4:p>","DOI":"10.12688\/f1000research.13944.1","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T10:16:03Z","timestamp":1519380963000},"page":"211","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Epigenetic silencing of lncRNA MORT in 16 TCGA cancer types"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3042-6275","authenticated-orcid":false,"given":"Lukas","family":"Vrba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard W.","family":"Futscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"1074-83","DOI":"10.1080\/15592294.2015.1106673","article-title":"A lincRNA connected to cell mortality and epigenetically-silenced in most common human cancers.","volume":"10","author":"L Vrba","year":"2015","journal-title":"Epigenetics."},{"key":"ref-2","article-title":"The Cancer Genome Atlas","year":"2016"},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"3980-90","DOI":"10.1158\/0008-5472.CAN-15-0506","article-title":"A Molecular Portrait of High-Grade Ductal Carcinoma In Situ.","volume":"75","author":"M Abba","year":"2015","journal-title":"Cancer Res."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/PREACCEPT-2333349012841587","article-title":"Genome-wide DNA methylation profiles in progression to in situ and invasive carcinoma of the breast with impact on gene transcription and prognosis.","volume":"15","author":"T Fleischer","year":"2014","journal-title":"Genome Biol."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13148-015-0094-0","article-title":"DNA methylation in ductal carcinoma in situ related with future development of invasive breast cancer.","volume":"7","author":"K Johnson","year":"2015","journal-title":"Clin Epigenetics."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"418-29.e8","DOI":"10.1053\/j.gastro.2014.04.039","article-title":"Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer.","volume":"147","author":"Y Luo","year":"2014","journal-title":"Gastroenterology."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"6403-6415","DOI":"10.1038\/onc.2016.170","article-title":"Integrated genomic analysis of colorectal cancer progression reveals activation of EGFR through demethylation of the EREG promoter.","volume":"35","author":"X Qu","year":"2016","journal-title":"Oncogene."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"e103896","DOI":"10.1371\/journal.pone.0103896","article-title":"Remodeling of the methylation landscape in breast cancer metastasis.","volume":"9","author":"M Reyngold","year":"2014","journal-title":"PLoS One."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"198-202","DOI":"10.4048\/jbc.2017.20.2.198","article-title":"Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes.","volume":"20","author":"L Vrba","year":"2017","journal-title":"J Breast Cancer."},{"key":"ref-10","article-title":"R: A Language and Environment for Statistical Computing","year":"2017"},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"5353-60","DOI":"10.26355\/eurrev_201712_13920","article-title":"Independent prognostic Factor of low-expressed LncRNA ZNF667-AS1 for cervical cancer and inhibitory function on the proliferation of cervical cancer.","volume":"21","author":"L Zhao","year":"2017","journal-title":"Eur Rev Med Pharmacol Sci."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/7-211\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-211\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-211\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T06:32:31Z","timestamp":1544077951000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/7-211\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.13944.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.15158.r31592","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.15158.r31096","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.15158.r31980","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.15158.r31592","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.15158.r31980","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.15158.r31096","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/7-211\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.15158.r31096, Adam Karpf, Eppley Institute and Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA, 01 Mar 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-211\/v1#referee-response-31096","order":0,"name":"referee-response-31096","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15158.r31980, Gwen Lomberk, Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA, 03 Apr 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-211\/v1#referee-response-31980","order":1,"name":"referee-response-31980","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15158.r31592, Alexander Dobrovic, Translational Genomics and Epigenomics Laboratory, Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia, 03 Apr 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-211\/v1#referee-response-31592","order":2,"name":"referee-response-31592","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by the Maynard Chair in Breast Cancer Epigenomics at the University of Arizona Cancer Center and the Cancer Center Support Grant (P30 CA023074). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}