{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:55Z","timestamp":1772168875974,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.139473.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000}},{"DOI":"10.12688\/f1000research.139473.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000}}],"reference-count":30,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Central Council for Research in Ayurveda Sciences","award":["STAR\/283\/7"],"award-info":[{"award-number":["STAR\/283\/7"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background Generalized anxiety disorder (GAD)\n                    <ns3:italic>(Chittodvega)<\/ns3:italic>\n                    is one among many types of mental disorders explained in Ayurveda. It can be defined as a\n                    <ns3:italic>Chitta<\/ns3:italic>\n                    (mind) +\n                    <ns3:italic>Udvega<\/ns3:italic>\n                    (anxiety)=\n                    <ns3:italic>Chittodvega<\/ns3:italic>\n                    - Anxious status of a mind.\n                    <ns3:italic>Celastrus paniculatus<\/ns3:italic>\n                    also known as\n                    <ns3:italic>Jyotishmati<\/ns3:italic>\n                    stimulates and improves the digestive fire and metabolism at a cellular level (\n                    <ns3:italic>Jatharagni and Majja dhatwagni).<\/ns3:italic>\n                    It can be correlated to GAD. GAD is characterized by feelings of threat, restlessness, irritability, sleep disturbance, and tension, and symptoms such as palpitations, dry mouth, and sweating. It affects women more frequently than men and prevalence rates are high in midlife (prevalence in females over age 35: 10%) and older subjects. In modern medicine the first-line psychological and pharmaceutical treatments are selective serotonin reuptake inhibitors (SSRIs) like sertraline (SNRIs). Aim and objectives To evaluate the comparative efficacy of\n                    <ns3:italic>Jyotishmati<\/ns3:italic>\n                    versus sertraline in the management of\n                    <ns3:italic>Chittodvega.<\/ns3:italic>\n                    Methods In this randomized active controlled double blind equivalence trial a total of 70 patients will be enrolled and divided into two equal groups. Patients between 20\u201350 years age of either gender having symptoms of\n                    <ns3:italic>Chittodvega<\/ns3:italic>\n                    and a Hamilton anxiety rating (HAM-A) scale score less than 24 (i.e., mild to moderate) will be selected for the study. In Group A, sertraline capsules 25 mg for first 7 days and then dose increased to 50 mg at bedtime for next 53 days and in Group B\n                    <ns3:italic>Jyotishmati<\/ns3:italic>\n                    Capsules 500 mg will be given twice a day after food with water for 60 days. Result and observation The patients will be assessed on the HAM-A scale, serum cortisol and WHO Quality of Life on day 0, 30, 60 and 90 and data will be analyzed using paired and unpaired t-tests for continuous variables and chi-square tests for categorical variables to evaluate whether treatments are equivalent. Trial registration CTRI No. REF\/2023\/07\/069880 Date \u2013 15\/09\/2023\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.139473.3","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T11:35:07Z","timestamp":1730115307000},"page":"1577","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus sertraline capsule in the management of Chittodvega (generalized anxiety disorder): protocol for a randomized controlled trial"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-2977","authenticated-orcid":false,"given":"Reeya","family":"Gamne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-0171","authenticated-orcid":false,"given":"Sadhana","family":"Misar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-5620","authenticated-orcid":false,"given":"Mayank","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"12-19","DOI":"10.4103\/0974-8520.85716","article-title":"Understanding personality from Ayurvedic perspective for psychological assessment: A case.","volume":"32","author":"S Shilpa","year":"2011","journal-title":"Ayu."},{"key":"ref4","article-title":"Clinical Evaluation of the Efficacy of Shankhapushpi Panak and Shirodhara with Mansyadi Kwatha in the Management of Chittodvega WSR to Generalized Anxiety Disorder.","volume":"9","author":"U Saroj","year":"2015","journal-title":"J. Ayurveda."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4103\/ijny.ijoyppp_24_19","article-title":"Vataja Unmada: Schizophrenia or Dementia or Mood Disorder with Psychosis?","volume":"8","author":"K Gupta","year":"2020","journal-title":"Int. J. Yoga - Philos. Psychol. Parapsychol."},{"key":"ref8","article-title":"A comparative study of brahmi taila and anutaila pratimarsha nasya in management of Generalized Anxiety Disorder (GAD) (Doctoral dissertation, Tilak Maharashtra Vidyapeeth, Pune).","author":"N Hiremath","year":"2022"},{"key":"ref9","article-title":"The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) includes the following diagnostic criteria: anxiety and worry that has lasted at least six months."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"17-29","DOI":"10.1007\/978-3-030-29081-8_3","article-title":"Epidemiology of psychiatric disorders in women.","author":"M Viana","year":"2020","journal-title":"Women\u2019s Mental Health: A Clinical and Evidence-Based Guide."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2475-2484","DOI":"10.1017\/S0033291711000754","article-title":"Testing the validity and acceptability of the diagnostic criteria for Hoarding Disorder: a DSM-5 survey.","volume":"41","author":"D Mataix-Cols","year":"2011","journal-title":"Psychol. Med."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"535-548","DOI":"10.1080\/14737175.2023.2211767","article-title":"Pharmacological Treatment of Generalised Anxiety Disorder: Current Practice and Future Directions.","volume":"23","author":"H Fagan","year":"2023","journal-title":"Expert. Rev. Neurother."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"ITC49-ITC64","DOI":"10.7326\/AITC201904020","article-title":"Generalized anxiety disorder.","volume":"170","author":"J DeMartini","year":"2019","journal-title":"Ann. Intern. Med."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1642-1649","DOI":"10.1176\/appi.ajp.161.9.1642","article-title":"Efficacy of sertraline in a 12-week trial for generalized anxiety disorder.","volume":"161","author":"C Allgulander","year":"2004","journal-title":"Am. J. Psychiatry."},{"key":"ref15","first-page":"29-30","article-title":"Role of \u201cJyotishmati\u201d in the treatment of CNS disorders.","author":"P Sharma","year":"2017","journal-title":"International Conference on \u201cRecent Advancement in Science & Technology\u201d (ICRAST 2017)."},{"key":"ref16","first-page":"147-153","article-title":"girishkj, nootropicherbin Ayurved, pharmacognrev.","volume":"6","author":"R Kulkarni"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"319-328","DOI":"10.1097\/00004850-200015060-00002","article-title":"Disabilities and quality of life in pure and comorbid generalized anxiety disorder and major depression in a national survey.","volume":"15","author":"H Wittchen","year":"2000","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref18","article-title":"Essentials of psychiatry, CBS publications & distributors darya-ganj New Delhi 4536\/1a 11.","author":"M Bhatia"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"100-106","DOI":"10.1159\/000065127","article-title":"The classification of anxiety disorders in ICD-10 and DSM-IV: a concordance analysis.","volume":"35","author":"G Andrews","year":"2002","journal-title":"Psychopathology."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"185-196","DOI":"10.1097\/YIC.0000000000000023","article-title":"A comparative review of escitalopram, paroxetine, and sertraline: are they all alike?","volume":"29","author":"C Sanchez","year":"2014","journal-title":"Int. Clin. Psychopharmacol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"134-147","DOI":"10.1002\/da.20658","article-title":"Generalized worry disorder: A review of DSM-IV generalized anxiety disorder and options for DSM-V.","volume":"27","author":"G Andrews","year":"2010","journal-title":"Depress. Anxiety."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"55-66","DOI":"10.1080\/j.1440-1614.2005.01510.x","article-title":"Disability, employment and work performance among people with ICD-10 anxiety disorders.","volume":"39","author":"G Waghorn","year":"2005","journal-title":"Aust. N Z J. Psychiatry."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"200-209","DOI":"10.4103\/JISM.JISM_71_20","article-title":"Pharmaceutico-analytical standardization and drug dosage modification of Dhatryadi Churna.","volume":"8","author":"S Shelke","year":"2020","journal-title":"J. Indian Syst. Med."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"255-262","DOI":"10.4103\/0253-7176.106022","article-title":"A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults.","volume":"34","author":"K Chandrasekhar","year":"2012","journal-title":"Indian J. Psychol. Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"995-997","DOI":"10.1177\/0004867413503719","article-title":"The status quo as a good outcome: how the DSM-5 diagnostic criteria for generalized anxiety disorder remained unchanged from the DSM-IV criteria.","volume":"47","author":"V Starcevic","year":"2013","journal-title":"Aust. N Z J. Psychiatry."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"601-601","DOI":"10.1093\/occmed\/kqv054","article-title":"Hamilton rating scale for anxiety (HAM-A).","volume":"65","author":"E Thompson","year":"2015","journal-title":"Occup. Med."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1-7","DOI":"10.1186\/1477-7525-1-1","article-title":"The Quality of Life Scale (QOLS): reliability, validity, and utilization.","volume":"1","author":"C Burckhardt","year":"2003","journal-title":"Health Qual. Life Outcomes."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"395-401","DOI":"10.1007\/s40012-020-00317-0","article-title":"Tele-counselling for management of Chittodvega (anxiety disorder) in Ayurveda--composing ancillary methods during the Covid 19 pandemic.","volume":"8","author":"K Roshni","year":"2020","journal-title":"CSI Trans. ICT."},{"key":"ref31","first-page":"346-359","article-title":"Generalized anxiety disorder.","volume":"2","author":"E Hoge","year":"2004","journal-title":"Focus."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"899-909","DOI":"10.1017\/S0033291709991036","article-title":"How common are common mental disorders? Evidence that lifetime prevalence rates are doubled by prospective versus retrospective ascertainment.","volume":"40","author":"T Moffitt","year":"2010","journal-title":"Psychol. Med."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"317-328","DOI":"10.1111\/jmwh.12607","article-title":"Selective serotonin reuptake inhibitors as first-line antidepressant therapy for perinatal depression.","volume":"62","author":"G Latendresse","year":"2017","journal-title":"J. Midwifery Womens Health."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"22-27","DOI":"10.4088\/PCC.v03n0105","article-title":"SSRI antidepressant medications: adverse effects and tolerability.","volume":"3","author":"J Ferguson","year":"2001","journal-title":"Prim. Care Companion J. Clin. Psychiatry."},{"key":"ref35","first-page":"112-118","article-title":"A review on Celastrus paniculatus wild (Jyotishmati): It\u2019s species, geographical sources, phytoconstituents, and therapeutic uses and pharmacological actions.","volume":"9","author":"S Dhumal","year":"2021","journal-title":"IJHM."},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.8125916","article-title":"Evaluation Of comparative efficacy of Celastrus paniculatus (Jyotishmati) capsule versus Sertraline capsule in the management Of Chittodvega (Generalized Anxiety Disorder) - RCT (Version V1).","author":"R Gamne","year":"2023","journal-title":"Zenodo."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T11:35:12Z","timestamp":1730115312000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":30,"URL":"https:\/\/doi.org\/10.12688\/f1000research.139473.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.139473.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.139473.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.173733.r349444","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.152749.r281408, Dr Savitha H P, Kayachikitsa and manasaroga, SDM College of Ayurveda & Hospital, Hassan, Karnataka, 05 Jun 2024, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-1577\/v1#referee-response-281408","order":0,"name":"referee-response-281408","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Reeya Gamne<\/b>; \n<i>Posted: 05 Jun 2024<\/i>; Thanks for the review.","URL":"https:\/\/f1000research.com\/articles\/12-1577\/v3#referee-comment-11718","order":1,"name":"referee-comment-11718","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.167827.r291859, Punam Khobarkar, Kayachikitsa, All India Institute of Ayurveda, New Delhi, 16 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1577\/v2#referee-response-291859","order":2,"name":"referee-response-291859","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.167827.r306252, Danish Javed, All India Institute of Medical Sciences, Bhopal, 05 Aug 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1577\/v2#referee-response-306252","order":3,"name":"referee-response-306252","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research is funded under the project \u201cScheme for Training in Ayurveda Research for Post Graduate Scholars\u201d (PG-STAR), Central Council for Research in Ayurveda Sciences (CCRAS) Ministry of AYUSH, Govt. of India under grant number STAR\/283\/7. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}