{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:09:19Z","timestamp":1780085359745,"version":"3.54.0"},"update-to":[{"DOI":"10.12688\/f1000research.139568.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000}},{"DOI":"10.12688\/f1000research.139568.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000}}],"reference-count":22,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T00:00:00Z","timestamp":1723420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Not any"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background In ayurveda, sciatica can be correlated to \u2018\n                    <ns3:italic>Grudhrasi\u2019<\/ns3:italic>\n                    under\n                    <ns3:italic>Vata Nanatmaja-Vyadhi<\/ns3:italic>\n                    (neurological disorders caused by\n                    <ns3:italic>Vata<\/ns3:italic>\n                    , one of the bodily humour). In this mainly bodily humours\n                    <ns3:italic>vata<\/ns3:italic>\n                    and\n                    <ns3:italic>kapha<\/ns3:italic>\n                    are vitiating producing symptoms like piercing pain, stiffness, twitching, numbness and pain radiating from lumbosacral region to lower limb up to the foot. Therapeutic plan includes stabilizing and bringing back the vitiated vata and kapha humours to equilibrium. The prevalence of sciatica varies considerably ranging from 3.8% in the working population to 7.9% in the nonworking population. Aim Comparative evaluation of efficacy of\n                    <ns3:italic>Rasonapinda<\/ns3:italic>\n                    and\n                    <ns3:italic>Trayodashang guggul<\/ns3:italic>\n                    as an adjuvant to\n                    <ns3:italic>katibasti<\/ns3:italic>\n                    (oil pooling therapy) in the management of\n                    <ns3:italic>Grudhrasi<\/ns3:italic>\n                    (Sciatica). Objectives To assess the efficacy of\n                    <ns3:italic>Rasonapinda<\/ns3:italic>\n                    as an adjuvant to\n                    <ns3:italic>katibasti<\/ns3:italic>\n                    in subjective and objective parameters of\n                    <ns3:italic>Grudhrasi<\/ns3:italic>\n                    (Sciatica). To assess the efficacy of\n                    <ns3:italic>Trayodashang guggul<\/ns3:italic>\n                    as an adjuvant to\n                    <ns3:italic>katibasti<\/ns3:italic>\n                    in subjective and objective parameters of\n                    <ns3:italic>Grudhrasi<\/ns3:italic>\n                    (Sciatica). To compare the efficacy of\n                    <ns3:italic>Rasonapinda<\/ns3:italic>\n                    and\n                    <ns3:italic>Trayodashang guggul<\/ns3:italic>\n                    as an adjuvant to\n                    <ns3:italic>katibasti<\/ns3:italic>\n                    in subjective and objective parameters. Standardisation of\n                    <ns3:italic>Rasonapinda<\/ns3:italic>\n                    (modified formvati). Methods In this study, a total of 60 patients will be enrolled and divided equally into two groups. In group A,\n                    <ns3:italic>Trayodashang Guggul<\/ns3:italic>\n                    500 mg twice a day after meal with warm water for 30 days adjuvant with katibasti for the initial 7 days will be given. In group B,\n                    <ns3:italic>Rasonapinda<\/ns3:italic>\n                    500 mg twice a day after meal with warm water adjuvant with katibasti for the initial 7 days will be given for 30 days. Result The result will be assessed on baseline of subjective and objective parameters and data will be compared after treatment. Conclusions It will be based on observations and results obtained. Trial registration CTRI No. - CTRI\/2022\/12\/048534 Dated \u2013 27\/12\/2022.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.139568.3","type":"journal-article","created":{"date-parts":[[2024,8,12]],"date-time":"2024-08-12T06:20:08Z","timestamp":1723443608000},"page":"9","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica):\u00a0 A randomized controlled trial"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-5620","authenticated-orcid":false,"given":"Mayank","family":"Rai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0165-0171","authenticated-orcid":false,"given":"Sadhana","family":"Misar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8960-2977","authenticated-orcid":false,"given":"Reeya","family":"Gamne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,8,12]]},"reference":[{"key":"ref3","doi-asserted-by":"publisher","first-page":"41-45","DOI":"10.4103\/0974-8520.169019","article-title":"Effect of Vatari Guggulu in the management of Gridhrasi (sciatica).","volume":"36","author":"G Sathavane","year":"2015","journal-title":"Ayu."},{"key":"ref4","first-page":"593","article-title":"Golwalla\u2019s medicine for students, Part 14 section 3, Root and plexus syndromes.","author":"A Golwalla"},{"key":"ref6","article-title":"\u201cBASIC DESCRIPTION OF GRIDHRASI (SCIATICA) ACCORDING TO AYURVED\u201d A LITERARY REVIEW.","author":"M Bairwa"},{"key":"ref7","article-title":"Synergistic Effect of TrayodashangaGuggulu and Yoga Basti in the Management of Low Back Pain with Special Reference to Gridhrasi.","volume":"8","author":"P Moharana","year":"December 2018","journal-title":"International Journal of Health Sciences & Research."},{"key":"ref8","article-title":"Gobind Das Sen with Vidhyotinihindi commentary by Ambika dutta Shastri, B.R. Vat-vyadhiadhikar, verse-89-90, Edition 1999, published by Chaukhamba Sanskrit Samsthana Varanasi.","author":"B Ratnavali"},{"key":"ref9","article-title":"ARYA AYURVEDIC CENTRE.","author":"V Rohini"},{"key":"ref10","article-title":"Gobind Das Sen with Vidhyotinihindi commentary by Ambika dutta Shastri, B.R. Vat-vyadhiadhikar, verse-89-90, Edition 1999, published by Chaukhamba Sanskrit Samsthana Varanasi.","author":"B Ratnavali"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.8126753","article-title":"Protocol On-Comparative evaluation of efficacy of Trayodashang Guggul versus Rasona Pinda as an adjuvant with Katibasti in the management of Grudhrasi (Sciatica): A Randomized Controlled Trial (Version v1).","author":"M Rai","year":"2023","journal-title":"Zenodo."},{"key":"ref12","article-title":"Bhaisajyaratnavali \u2013shri govind das virachita, vyakhyaakarkavirajsriambikadutt shastri ayurvedacharya, chaukhambhaprakashana, Varanasi, sanvata 2073,5\/1406 shirorogachikitsaprakashan 65\/111-112."},{"key":"ref13","article-title":"Gobind Das Sen with Vidhyotinihindi commentary by Ambika dutta Shastri, B.R. Vat-vyadhiadhikar, verse-89-90, Edition 1999, published by Chaukhamba Sanskrit Samsthana Varanasi.","author":"B Ratnavali"},{"key":"ref14","first-page":"107-109","article-title":"Edited and Enlarged by Bhaisagratna Sri Brahma Shankar Mishra with \u201cvidyotini\u201d Hindi Commentary by Shri KavirajAmbikadatta Shastri, published by ChaukambhaPrakashan Varanasi, Reprint year.","volume":"65","author":"B Kaviraj","year":"2016"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"343-349","DOI":"10.46607\/iamj0309022021","article-title":"A Clinical Comparative Study On Management Of Grudhrasi (Sciatica) With RasnaGuggulu And TrayodashangGuggulu.","volume":"9","author":"P Chaudhary","year":"2021","journal-title":"International Ayurvedic Medical Journal."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2940-2952","DOI":"10.1097\/00007632-200011150-00017","article-title":"Oswestry Low Back Pain Disability Questionnaire Sources: Fairbank Jct&Pynsent, Pb (2000) The Oswestry Disability Index.","volume":"25","journal-title":"Spine."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"343-349","DOI":"10.46607\/iamj0309022021","article-title":"A Clinical Comparative Study On Management Of Gridhrasi (Sciatica) With Rasna Guggulu And Trayodashang Guggulu.","volume":"9","author":"P Chaudhary","year":"2021","journal-title":"International Ayurvedic Medical Journal."},{"key":"ref21","first-page":"389","article-title":"Agnivesha, Charaka Samhita with Charaka Chandrika Hindi Commentary by Dr. Brahmanand Tripathi, Part 1, Sutrasthana 20\/11, 1st Edition (reprint), Varanasi: Chaukhambha Krishnadas Academy.","year":"2009"},{"key":"ref22","first-page":"389","article-title":"Agnivesha, Charaka Samhita with Charaka Chandrika Hindi Commentary by Dr. Brahmanand Tripathi, Part 1, Sutrasthana 20\/11, 1st Edition (reprint), Varanasi: Chaukhambha Krishnadas Academy.","year":"2009"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"100281","DOI":"10.1016\/j.phyplu.2022.100281","article-title":"Analgesic and Anti-inflammatory Activities of TrayodashangGuggulu, an Ayurvedic Formulation.","volume":"2","author":"S Gupta","year":"2022","journal-title":"PhytomedicinePlus."},{"key":"ref24","article-title":"Synergistic Effect of TrayodashangaGuggulu and Yoga Basti in the Management of Low Back Pain with Special Reference to Gridhrasi.","volume":"8","author":"P Moharana","year":"December 2018","journal-title":"International Journal of Health Sciences & Research."},{"key":"ref25","article-title":"Gobind Das Sen with Vidhyotinihindi commentary by Ambika dutta Shastri, B.R. Vat-vyadhiadhikar, verse-89-90, Edition 1999, published by Chaukhamba Sanskrit Samsthana Varanasi.","author":"B Ratnavali"},{"key":"ref26","article-title":"Varanasi:Chaukhamba Bharati Academy.","year":"2003"},{"key":"ref27","doi-asserted-by":"publisher","year":"1969","DOI":"10.5281\/zenodo.8126753"},{"key":"ref29","first-page":"173-177","article-title":"Bhojani\u2019efficacy Of katibasti And Samanausadhi In The Management Of Grudhrasi (Sciatica) - A Comparative Clinical Studyaryavaidyan.","volume":"Xxviii","author":"B Pooja","year":"Feb. - Apr. 2015"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-9\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-9\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-9\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T08:15:16Z","timestamp":1729152916000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-9\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,12]]},"references-count":22,"URL":"https:\/\/doi.org\/10.12688\/f1000research.139568.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.139568.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.139568.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.170138.r313360","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.170138.r328942","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.170138.r328942","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.170138.r313360","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,12]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-9\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.170138.r313360, Shrilatha Kamath, Sri Dharmasthala Manjunatheshwara College of Ayurveda, Udupi, Karanataka, 23 Aug 2024, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-9\/v3#referee-response-313360","order":0,"name":"referee-response-313360","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.152851.r281463, Vaibhav Bapat, National Institute of Ayurveda Deemed University, Jaipur, Rajasthan, 20 Jun 2024, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-9\/v1#referee-response-281463","order":1,"name":"referee-response-281463","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Mayank Rai<\/b>; \n<i>Posted: 21 Jun 2024<\/i>; Respected Sir\/Ma'am,  I have made all the corrections suggested to me by you. I have mentioned control and interventional groups.&nbsp;\n<i>Katibasti <\/i>taken as adjuvant therapy in the study only for initial seven days. \n<i>Katibasti<\/i> will be continued in menstruating females as per their consent if given priority to disease symptoms.  Thanking you, Yours truly,  Mayank Rai PG Scholar&nbsp; MGACH&amp;RC, DMIHER,Wardha","URL":"https:\/\/f1000research.com\/articles\/13-9\/v3#referee-comment-11840","order":2,"name":"referee-comment-11840","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.170138.r328942, Maheshwor Bhatta, Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, 17 Oct 2024, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-9\/v3#referee-response-328942","order":3,"name":"referee-response-328942","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}