{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:29Z","timestamp":1772168909913,"version":"3.50.1"},"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns7:p>\n                    <ns7:bold>Background:<\/ns7:bold>\n                    Ocular hypertension (OH) is a condition characterized by elevated intraocular pressure (IOP) exceeding the normal range, without any evident damage to the optic nerve or visual field defects characteristic of glaucoma. It constitutes a significant precursor to the development of glaucoma, a leading cause of irreversible vision loss worldwide. Emerging evidence has shown that microcirculation alterations in eyes with OH could serve as predicting factors to identify eyes at high risk for progression to glaucoma. In view of the above, the purpose of our study is to investigate microcirculation alterations of the radial peripapillary capillary plexus using optical coherence tomography angiography (OCT-A) in patients with ocular hypertension (OH).\n                  <\/ns7:p>\n                  <ns7:p>\n                    <ns7:bold>Methods:<\/ns7:bold>\n                    A total of 192 eyes were included in this observational, comparative, single-centre study and were divided in two groups: OH eyes and healthy controls. OCT-A was performed to analyze microcirculation characteristics at the peripapillary area. Radial peripapillary capillary density was measured at the total area of the optic disc and at each separate region (superior, inferior, inside). The parameters of age, medical treatment for ocular hypertension, sex and retinal fiber layer thickness were evaluated.\u00a0\n                  <\/ns7:p>\n                  <ns7:p>\n                    <ns7:bold>Results:<\/ns7:bold>\n                    Total radial peripapillary capillary density was significantly lower in patients with OH than in healthy controls Concerning the microcirculation characteristics at each separate region of the peripapillary area, the results were as follows: inferior radial peripapillary capillary density was significantly decreased in individuals with OH than in controls, while measurements in the superior peripapillary area and internal optic disc were similar in both groups. \u00a0\n                  <\/ns7:p>\n                  <ns7:p>\n                    <ns7:bold>Conclusions:<\/ns7:bold>\n                    Our study indicates decreased radial peripapillary capillary density in eyes with OH. Microcirculation alterations in the inferior peripapillary area could potentially comprise biomarkers for OH progression to glaucoma.\n                  <\/ns7:p>","DOI":"10.12688\/f1000research.140453.1","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:20:33Z","timestamp":1699611633000},"page":"1456","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Radial peripapillary capillary density as a predictive factor for glaucoma in eyes with ocular hypertension. An observational, comparative, single-centred study"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4255-7830","authenticated-orcid":false,"given":"Elpida","family":"Kollia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evita-Evangelia","family":"Christou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni","family":"Patsea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Styliani Alexia","family":"Papadonta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Papaconstantinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e17138","DOI":"10.7759\/cureus.17138","article-title":"Correlation Between Central Corneal Thickness and Radial Peripapillary Capillary Density, in Patients with Ocular Hypertension.","volume":"13","author":"E Kollia","year":"2021 Aug 12","journal-title":"Cureus."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2533-2543","DOI":"10.1007\/s10792-023-02653-x","article-title":"Inner retinal layers' alterations of the microvasculature in early stages of Parkinson's disease: a cross sectional study. 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Ophthalmol."},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.17632\/h9tntd4gkf.1","volume":"V1","author":"E Kollia","year":"2023","journal-title":"Mendeley Data."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T02:30:22Z","timestamp":1703730622000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":21,"URL":"https:\/\/doi.org\/10.12688\/f1000research.140453.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.153805.r229782","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r224092","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r224087","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r224092","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r229783","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r229782","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r229781","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.153805.r224087","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,10]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.153805.r224092, Susmito Biswas, Manchester Royal Eye Hospital, Manchester, 07 Dec 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1#referee-response-224092","order":0,"name":"referee-response-224092","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.153805.r224087, Panagiotis Sergouniotis, University of Manchester, Manchester, 22 Dec 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1#referee-response-224087","order":1,"name":"referee-response-224087","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.153805.r229782, Anastasios Lavaris, National and Kapodistrian University of Athens, Athens, 28 Dec 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1456\/v1#referee-response-229782","order":2,"name":"referee-response-229782","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}