{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:04Z","timestamp":1772168884365,"version":"3.50.1"},"reference-count":18,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Purpose:\u00a0<\/ns3:bold>\n                    We report a case of focal choroidal excavation (FCE) that resolved after intravitreal injection of anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) and we describe its tomographic features.\n                  <\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Case report:\u00a0<\/ns3:bold>\n                    A 43-year-old female presented with blurred vision and metamorphopsia in her left eye (LE) evolving for 10 years. The best corrected visual acuity (BCVA) was 20\/20 in the right eye and 20\/32 in the LE. Fundus examination revealed the presence\u00a0of a yellowish foveal lesion which corresponded to a conforming FCE associated to a pachychoroid on swept-source optical coherence tomography (OCT). The OCT-Angiography showed a foveal flow void in the choriocapillaris layer corresponding to the FCE area.\n                  <\/ns3:p>\n                  <ns3:p>Three years later, the patient complained of visual impairment, more metamorphopsia with a BCVA of 20\/80 on her LE. The OCT showed intraretinal fluid with a foveal retinal pigment epithelium (RPE) detachment. The OCT-angiography confirmed the presence of CNV. Two months after one intravitreal bevacizumab injection, the OCT documented the complete resolution of macular edema, the regression of the CNV tissue and the restoration of a normal aspect of the fovea without any FCE. Her BCVA improved to 20\/32 with resolution of the metamorphopsia. The OCT aspect remained stable during 3 years of follow-up.<\/ns3:p>\n                  <ns3:p>\n                    <ns3:bold>Conclusion:\u00a0<\/ns3:bold>\n                    CNV can develop in FCE and anti-VEGF therapy is a good option treatment. After treatment, FCE pattern can change et may completely resolve.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.141099.1","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T04:20:10Z","timestamp":1696479610000},"page":"1270","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8911-0139","authenticated-orcid":false,"given":"Im\u00e8ne","family":"Zhioua Braham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Haddar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mejdi","family":"Boukari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Mokrani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhem","family":"Mili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raja","family":"Zhioua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1320-1325","DOI":"10.1001\/archophthalmol.2011.148","article-title":"The expanded spectrum of focal choroidal excavation.","volume":"129","author":"R Margolis","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"918-923","DOI":"10.1136\/bjophthalmol-2015-307055","article-title":"Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathy and central serous chorioretinopathy.","volume":"100","author":"F Lim","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1534-1535","DOI":"10.1016\/j.ophtha.2015.01.012","article-title":"Focal choroidal excavation in multifocal choroiditis and punctate inner choroidopathy.","volume":"122","author":"H Kim","year":"2015","journal-title":"Ophthalmology."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e12-e20","DOI":"10.1097\/OPX.0000000000000443","article-title":"Focal choroidal excavation associated with focal retinochoroiditis.","volume":"92","author":"T Ohki","year":"2015","journal-title":"Optom. Vis. 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Eye Res."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"199-221","DOI":"10.1097\/IAE.0000000000001345","article-title":"Focal choroidal excavation and its association with pachychoroid spectrum disorders: a review of the literature and multimodal imaging findings.","volume":"37","author":"H Chung","year":"2017","journal-title":"Retina."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1072-1076","DOI":"10.1097\/01.iae.0000248819.86737.a5","article-title":"Diagnostic and therapeutic challenges.","volume":"26","author":"L Jampol","year":"2006","journal-title":"Retina."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1320-1325","DOI":"10.1001\/archophthalmol.2011.148","article-title":"The expanded spectrum of focal choroidal excavation.","volume":"129","author":"R Margolis","year":"2011","journal-title":"Arch. 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Ophthalmol."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"918-923","DOI":"10.1136\/bjophthalmol-2015-307055","article-title":"Prevalence and clinical correlates of focal choroidal excavation in eyes with age-related macular degeneration, polypoidal choroidal vasculopathie and central serous chorioretinopathy.","volume":"100","author":"F Lim","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"419-423","DOI":"10.18502\/jovr.v15i3.7461","article-title":"Focal choroidal excavation in a case of choroidal osteoma associated with choroidal neovascularization.","volume":"15","author":"M Azimizadeh","year":"2020","journal-title":"J. Ophthalmic Vis. Res."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1201-1210","DOI":"10.1097\/IAE.0b013e31827b6452","article-title":"Tomographic and angiographic characteristics of eyes with macular focal choroidal excavation.","volume":"33","author":"R Obata","year":"2013","journal-title":"Retina."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"987-996","DOI":"10.1097\/IAE.0000000000002980","article-title":"Choroidal inflammation and choriocapillaris ischemia in focal choroidal excavation in comparison to pachychoroid neovasculopathy.","volume":"41","author":"E Seo","year":"2021","journal-title":"Retina."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"293-296","DOI":"10.1097\/ICB.0000000000000301","article-title":"Focal choroidal excavation and choroidal neovascularization with associated pachychoroid.","volume":"10","author":"Q Ghadiali","year":"2016","journal-title":"Retin Cases Brief Rep."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"980-984","DOI":"10.18240\/ijo.2019.06.16","article-title":"Focal choroidal excavation complicated with choroidal neovascularization in young and middle aged patients.","volume":"12","author":"W Tang","year":"2019","journal-title":"Int. J. Ophthalmol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"246-250","DOI":"10.1016\/j.ophtha.2013.08.014","article-title":"Focal choroidal excavation complicated by choroidal neovascularization.","volume":"121","author":"H Xu","year":"2014","journal-title":"Ophthalmology."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T08:00:36Z","timestamp":1710921636000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,5]]},"references-count":18,"URL":"https:\/\/doi.org\/10.12688\/f1000research.141099.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.154513.r212716","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.154513.r256520","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.154513.r212716","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.154513.r256520","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,5]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.154513.r212716, Imen Ksiaa, University of Monastir, Monastir, 01 Nov 2023, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1#referee-response-212716","order":0,"name":"referee-response-212716","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.154513.r256520, Niroj Kumar Sahoo, Department of Retina and Vitreous, Anant Bajaj Retina Institute, L V Prasad Eye Institute, Vijayawada, 20 Mar 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1270\/v1#referee-response-256520","order":1,"name":"referee-response-256520","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}