{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:50:48Z","timestamp":1790704248306,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.141339.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000}}],"reference-count":10,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Cholinergic urticaria (CholU) is a rare condition characterized by itchy hives in the form of 1-4 mm small, raised wheals on skin, which are short-lived for duration of 15 to 20 minutes; they are caused by stimuli associated with sweating such as from physical exercise. CholU is also known as cholinergic angioedema urticaria. Hereby, we present a case report of a 42-year-old male with ChoIU who presented with systemic manifestation in the form of recurrent attacks of syncope. Diagnosis was made after a detailed history taking and all cardiac and neurological evaluations done that were normal, and widespread literature research was done to rule out other causes of syncope as systemic symptoms are rarely seen in ChoIU. His IgE antibodies levels were highly increased. He was managed with nonsedating antihistamines and health education regarding the rare condition.<\/ns3:p>","DOI":"10.12688\/f1000research.141339.2","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T10:36:59Z","timestamp":1720694219000},"page":"1193","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Hives and faints, an unusual affair"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-2835","authenticated-orcid":false,"given":"Saket","family":"Toshniwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwan","family":"Kinkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourya","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhukar","family":"Tikas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0938-0508","authenticated-orcid":false,"given":"Isha","family":"Sahai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7895-5988","authenticated-orcid":false,"given":"Benumadhab","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3503-6954","authenticated-orcid":false,"given":"Suhit","family":"Naseri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13647","article-title":"Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis.","volume":"33","author":"T Minowa","year":"2020 Jul","journal-title":"Dermatol. Ther."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1-6","DOI":"10.1155\/2020\/7301652","article-title":"Nattacha Chanchaemsri, and Kanokvalai KulthananCholinergic Urticaria: Clinical Presentation and Natural History in a Tropical CountryCholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country.","volume":"2020","author":"C Rujitharanawong","year":"2020 May 24","journal-title":"Biomed. Res. Int."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4103\/0972-6691.187569","article-title":"Asthma and Immunology Rash before shock: A case of cholinergic urticaria associated with syncope.","volume":"30","author":"A Vaggu","year":"Jan-Jun 2016","journal-title":"Srivastava Indian Journal of Allergy."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"284-291","DOI":"10.1016\/j.jaip.2015.09.021","article-title":"Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity.","volume":"4","author":"P Vadas","year":"2016 Mar-Apr","journal-title":"J Allergy Clin Immunol Pract."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"539-544","DOI":"10.2332\/allergolint.12-RAI-0485","article-title":"Pathogenesis of cholinergic urticaria in relation to sweating.","volume":"61","author":"T Bito","year":"2012","journal-title":"Allergol. Int."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1609-1614","DOI":"10.1111\/cea.13023","article-title":"Cholinergic urticaria patients of different age groups have distinct features.","volume":"47","author":"A Asady","year":"2017 Dec","journal-title":"Clin. Exp. Allergy."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"189-194","DOI":"10.5021\/ad.2014.26.2.189","article-title":"Clinical Characteristics of Cholinergic Urticaria in Korea.","volume":"26","author":"J Kim","year":"2014 Apr","journal-title":"Ann. Dermatol."},{"key":"ref8","first-page":"1298-1305","article-title":"Regular sports exercises as a supportive therapeutic choice in cholinergic urticaria.","volume":"33","author":"T Kubaisi","year":"2023 Oct 12","journal-title":"J. Pak. Assoc. Dermatol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"780-802","DOI":"10.1111\/all.12884","article-title":"The definition, diagnostic testing, and management of chronic inducible urticarias - the EAACI\/GA2LEN\/EDF\/UNEV consensus recommendations 2016 update and revision.","volume":"71","author":"M Magerl","year":"2016","journal-title":"Allergy."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"479-483","DOI":"10.1016\/0091-6749(81)90202-5","article-title":"Evaluation of a patient with both aquagenic and cholinergic urticaria.","volume":"68","author":"R Davis","year":"1981","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T06:45:51Z","timestamp":1721285151000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":10,"URL":"https:\/\/doi.org\/10.12688\/f1000research.141339.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.141339.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.168833.r300984","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.168833.r300984","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.154774.r270954, Oc\u00edlio Ribeiro Gon\u00e7alves, Federal University of Piau\u00ed (UFPI), Teresina, 17 May 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/12-1193\/v1#referee-response-270954","order":0,"name":"referee-response-270954","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.168833.r300984, Thamir A Kubaisi, Department of Dermatology, University of Anbar, Ramadi, Al Anbar Governorate, 18 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1193\/v2#referee-response-300984","order":1,"name":"referee-response-300984","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}