{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:38:05Z","timestamp":1778233085978,"version":"3.51.4"},"reference-count":27,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Two notable findings of clinically healthy feedlot cattle suggest they may have pulmonary hydrostatic edema during the finishing phase of production: increased pulmonary arterial wedge pressures and pulmonary venous hypertrophy. The goal of this study was to determine if increased pulmonary arterial wedge pressure (PAWP) in a Holstein calf could lead to diffuse alveolar damage consistent with the early, exudative phase of acute interstitial pneumonia of feedlot cattle.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:<\/ns4:bold>\n                    Six male Holstein dairy calves were given daily subcutaneous injections of the nonspecific \u00df-adrenergic agonist isoprenaline (10 mg\/kg\/d), to induce left ventricular diastolic dysfunction, or sterile water for 14 days. On Day 14, pulmonary arterial pressures and wedge pressures were measured, echocardiography performed, and the ratio of mitral valve flow velocity (E) to septal lengthening velocity (e\u2019) calculated. Calves were euthanized on Day 15 and lung lesions semi-quantitatively scored.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:<\/ns4:bold>\n                    Mean PAWP was 12 \u00b1 1 mm Hg in calves that received isoprenaline and 7 \u00b1 1 mm Hg in controls (\n                    <ns4:italic>P =<\/ns4:italic>\n                    0.01). Calves that received isoprenaline tended to have greater relative wall thickness than control calves (\n                    <ns4:italic>P =<\/ns4:italic>\n                    0.15) and greater E\/e\u2019 ratios (\n                    <ns4:italic>P =<\/ns4:italic>\n                    0.16), suggestive of concentric hypertrophy and diastolic dysfunction, respectively. Calves that received isoprenaline also tended to have a left ventricle and interventricular septum that was 29 \u00b1 10 g heavier than control calves (\n                    <ns4:italic>P =<\/ns4:italic>\n                    0.10) when controlling for body mass. Hyaline membranes, the hallmark feature of diffuse alveolar damage, were evident in lung sections from all calves that received isoprenaline but none of the controls.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:<\/ns4:bold>\n                    Consistent with prior pathological and physiological studies of feedlot cattle, this study provides preliminary evidence that cattle presenting with clinical signs and pathology consistent with early stage acute interstitial pneumonia could be attributable to hydrostatic edema associated with left ventricular failure.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.14153.1","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T05:05:04Z","timestamp":1522040704000},"page":"374","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Preliminary evidence that hydrostatic edema may contribute to the formation of diffuse alveolar damage in a Holstein calf model"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8438-2234","authenticated-orcid":false,"given":"Joseph M.","family":"Neary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dee","family":"Church","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"326-334","DOI":"10.1111\/jvim.13789","article-title":"Right-Sided Congestive Heart Failure in North American Feedlot Cattle.","volume":"30","author":"J Neary","year":"2016","journal-title":"J Vet Intern Med."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"1519-1524","DOI":"10.2460\/ajvr.2001.62.1519","article-title":"Involvement of microbial respiratory pathogens in acute interstitial pneumonia in feedlot cattle.","volume":"62","author":"G Loneragan","year":"2001","journal-title":"Am J Vet Res."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"2526-2533","DOI":"10.1001\/jama.2012.5669","article-title":"Acute respiratory distress syndrome: the Berlin Definition.","volume":"307","author":"V Ranieri","year":"2012","journal-title":"JAMA."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"333-339","DOI":"10.1111\/j.1476-4431.2007.00238.x","article-title":"Acute lung injury and acute respiratory distress syndromes in veterinary medicine: consensus definitions: The Dorothy Russell Havemeyer Working Group on ALI and ARDS in Veterinary Medicine.","volume":"17","author":"P Wilkins","year":"2007","journal-title":"J Vet Emerg Crit Care."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"381-9","DOI":"10.1016\/j.cvfa.2015.05.010","article-title":"Feedlot Acute Interstitial Pneumonia.","volume":"31","author":"A Woolums","year":"2015","journal-title":"Vet Clin North Am Food Anim Pract."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"2416-2430","DOI":"10.1016\/S0140-6736(16)00578-X","article-title":"Acute respiratory distress syndrome.","volume":"388","author":"R Sweeney","year":"2016","journal-title":"Lancet."},{"key":"ref-7","article-title":"Epidemiological, physiological and genetic risk factors associated with congestive heart failure and mean pulmonary arterial pressure in cattle.","author":"J Neary","year":"2014"},{"key":"ref-8","article-title":"Guide for the Care and Use of Laboratory Animals.","year":"2011"},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"493-501","DOI":"10.1007\/s11427-011-4183-9","article-title":"Distinct actions of intermittent and sustained \u03b2-adrenoceptor stimulation on cardiac remodeling.","volume":"54","author":"X Ma","year":"2011","journal-title":"Sci China Life Sci."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"7-11","DOI":"10.1016\/0002-9149(76)90491-4","article-title":"Problems in echocardiographic volume determinations: echocardiographic-angiographic correlations in the presence of absence of asynergy.","volume":"37","author":"L Teichholz","year":"1976","journal-title":"Am J Cardiol."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"2539-2550","DOI":"10.1093\/eurheartj\/ehm037","article-title":"How to diagnose diastolic heart failure: a consensus statement on the diagnosis of heart failure with normal left ventricular ejection fraction by the Heart Failure and Echocardiography Associations of the European Society of Cardiology.","volume":"28","author":"W Paulus","year":"2007","journal-title":"Eur Heart J."},{"key":"ref-12","first-page":"1-12","article-title":"Using the Student \u2019s t-test with extremely small sample sizes.","volume":"18","author":"J de Winter","year":"2013","journal-title":"Pr Assessment, Res Evalutaion."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"725-738","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals.","volume":"44","author":"G Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"172-177","DOI":"10.1161\/01.RES.10.2.172","article-title":"High altitude-induced pulmonary hypertension in normal cattle.","volume":"10","author":"D Will","year":"1962","journal-title":"Circ Res."},{"key":"ref-15","first-page":"531-546","article-title":"The pulmonary circulation: remodeling in growth and disease. The 1978 J. Burns Amberson lecture.","volume":"119","author":"L Reid","year":"1979","journal-title":"Am Rev Respir Dis."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"966-70","DOI":"10.1161\/01.RES.11.6.966","article-title":"Role of pulmonary lymphatics in chronic pulmonary edema.","volume":"11","author":"H Uhley","year":"1962","journal-title":"Circ Res."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"L530-40","DOI":"10.1152\/ajplung.00324.2011","article-title":"Altered lymphatics in an ovine model of congenital heart disease with increased pulmonary blood flow.","volume":"302","author":"S Datar","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"ref-18","doi-asserted-by":"publisher","first-page":"317-325","DOI":"10.1161\/01.RES.77.2.317","article-title":"Pulmonary microvascular permeability. Responses to high vascular pressure after induction of pacing-induced heart failure in dogs.","volume":"77","author":"M Townsley","year":"1995","journal-title":"Circ Res."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"1082-1092","DOI":"10.1007\/s10439-009-9684-3","article-title":"High pulsatility flow induces adhesion molecule and cytokine mRNA expression in distal pulmonary artery endothelial cells.","volume":"37","author":"M Li","year":"2009","journal-title":"Ann Biomed Eng."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"561-571","DOI":"10.1159\/000226224","article-title":"Effects of pathological flow on pulmonary artery endothelial production of vasoactive mediators and growth factors.","volume":"46","author":"M Li","year":"2009","journal-title":"J Vasc Res."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"1090-1102","DOI":"10.1378\/chest.124.3.1090","article-title":"Alveolar-capillary membrane dysfunction in heart failure: evidence of a pathophysiologic role.","volume":"124","author":"M Guazzi","year":"2003","journal-title":"Chest."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"1170-1178","DOI":"10.1161\/HYPERTENSIONAHA.111.186072","article-title":"Left ventricular failure produces profound lung remodeling and pulmonary hypertension in mice: heart failure causes severe lung disease.","volume":"59","author":"Y Chen","year":"2012","journal-title":"Hypertension."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.12688\/f1000research.12717.1","article-title":"Development of pulmonary arterial hypertension and diffuse alveolar damage in 2-month old Holstein dairy calves following an acute episode of bloody scours [version 1; referees: 1 approved, 1 approved with reservations].","volume":"6","author":"K Gonyeau","year":"2017","journal-title":"F1000Res."},{"key":"ref-24","doi-asserted-by":"publisher","DOI":"10.7910\/DVN\/HD1GEI","article-title":"Heart and lungs of Holstein calves","author":"J Neary","year":"2018"},{"key":"ref-25","doi-asserted-by":"publisher","DOI":"10.7910\/DVN\/UR9MAC","article-title":"Pulmonary histology of Holstein calves","author":"J Neary","year":"2018"},{"key":"ref-26","doi-asserted-by":"publisher","DOI":"10.7910\/DVN\/ZBIVAG","article-title":"Hepatic histology of Holstein calves","author":"J Neary","year":"2018"},{"key":"ref-27","doi-asserted-by":"publisher","DOI":"10.7910\/DVN\/SKBMWZ","article-title":"Cardiopulmonary pressures in Holstein calves","author":"J Neary","year":"2018"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/7-374\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-374\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-374\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T06:07:56Z","timestamp":1544076476000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/7-374\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":27,"URL":"https:\/\/doi.org\/10.12688\/f1000research.14153.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.15397.r37946","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.15397.r37016","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.15397.r37946","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.15397.r37016","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/7-374\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.15397.r37016, Amelia Woolums, Department of Pathobiology and Population Medicine, Mississippi State University, Starkville, MS, USA, 23 Oct 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-374\/v1#referee-response-37016","order":0,"name":"referee-response-37016","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15397.r37946, Min Li, Developmental Lung Biology, Cardiovascular Pulmonary Research Laboratories, University of Colorado Denver, Denver, CO, USA, 28 Nov 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-374\/v1#referee-response-37946","order":1,"name":"referee-response-37946","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}