{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:19:31Z","timestamp":1790813971420,"version":"4.1.0"},"reference-count":19,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006378","name":"Universitas Indonesia","doi-asserted-by":"publisher","award":["NKB-393\/UN2.RST\/HKP.05.00\/2023"],"award-info":[{"award-number":["NKB-393\/UN2.RST\/HKP.05.00\/2023"]}],"id":[{"id":"10.13039\/501100006378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Azoospermia is the most severe type of male infertility. This study aimed to identify useful clinical parameters to predict sperm retrieval success. This could assist clinicians in accurately diagnosing and treating patients based on the individual clinical parameters of patients. Methods A retrospective cohort study was performed involving 517 patients with azoospermia who underwent sperm retrieval in Jakarta, Indonesia, between January 2010 and April 2023. Clinical evaluation and scrotal ultrasound, serum follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels were evaluated before surgery. Multivariate analyses were conducted to determine clinical parameters that could predict overall sperm retrieval success. Further subgroup analysis was performed to determine the factors that the diagnosis of non-obstructive azoospermia (NOA) diagnosis and sperm retrieval success among patients with NOA. Results A total of 2,987 infertile men attended our clinic. Men with azoospermia (n=517) who met the inclusion criteria and did not fulfil any exclusion criteria were included in the study. The overall sperm retrieval success was 47.58%. Logistic regression revealed that FSH 7.76 mIU\/mL (sensitivity: 60.1%, specificity: 63.3%, p&lt;0.001); longest testicular axis length 3.89 cm (sensitivity: 33.6%, specificity: 41.6%); and varicocele (p&lt;0.001) were independent factors for overall sperm retrieval. The FSH cutoff of 7.45 mIU\/mL (sensitivity: 31.3%, specificity: 37.7%, p&lt;0,001); longest testicular axis length 3.85 cm (sensitivity: 76.7%, specificity: 65.4%, p&lt;0.001); and varicocele (p&lt;0.001) were independent factors for NOA diagnosis. Varicocele was the only clinical parameter that significantly predicted the success of sperm retrieval in patients with NOA. Conclusions FSH, LH, longest testicular axis, and varicocele are among the clinical parameters that are useful for predicting overall sperm retrieval success and NOA diagnosis. However, varicocele is the only clinical parameter that significantly predicts sperm retrieval success in patients with NOA. High-quality studies are required to assess the other predictors of sperm retrieval success.<\/ns3:p>","DOI":"10.12688\/f1000research.141969.1","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:20:32Z","timestamp":1701865232000},"page":"1567","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical parameters as predictors for sperm retrieval success in azoospermia: experience from Indonesia"],"prefix":"10.12688","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-805X","authenticated-orcid":false,"given":"Rinaldo Indra","family":"Rachman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghifari","family":"Nurullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7793-7083","authenticated-orcid":false,"given":"Widi","family":"Atmoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-755X","authenticated-orcid":false,"given":"Nur","family":"Rasyid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yong","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-6753","authenticated-orcid":false,"given":"Ponco","family":"Birowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"ref1","first-page":"1-87","article-title":"EAU Guidelines on Urolithiasis.","volume":"2018","author":"C T\u00fcrk","year":"2018","journal-title":"Eur. 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Soebadi, Department of Urology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, 06 Feb 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1567\/v1#referee-response-229809","order":0,"name":"referee-response-229809","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.155459.r235153, Dragos Puia, University for Medicine and Pharmacy, Iasi, 07 Feb 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1567\/v1#referee-response-235153","order":1,"name":"referee-response-235153","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by HIBAH PUTI 2023 Universitas Indonesia NKB-393\/UN2.RST\/HKP.05.00\/2023. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}