{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T13:43:40Z","timestamp":1780407820052,"version":"3.54.1"},"update-to":[{"DOI":"10.12688\/f1000research.142072.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000}}],"reference-count":14,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    <ns3:bold>Introduction:<\/ns3:bold>\n                    Cystic echinococcosis (CE), caused by\n                    <ns3:italic>Echinococcus granulosus sensu lato<\/ns3:italic>\n                    , is a parasitic disease prevalent in endemic regions. CE frequently leads to the formation of hydatid cysts in various organs, with the liver being the most commonly affected site. Involvement of the spleen has been rarely reported in the literature. Managing disseminated hydatid cyst disease presents significant diagnostic and therapeutic challenges.\n                    <ns3:bold>Case presentation:<\/ns3:bold>\n                    A 40-year-old female with a past medical history of hypothyroidism presented with sudden onset shortness of breath, dry cough, and chest pain for 3 days. She had a recent travel history to Egypt. Physical examination revealed mild right upper quadrant tenderness. Laboratory findings showed elevated white blood cell count with eosinophilia and increased inflammatory markers. Chest X-ray and pan-computed tomography (Pan-CT) scans identified multiple cystic lesions in the lung, liver and spleen. Serological tests confirmed the presence of anti-Echinococcus antibodies, leading to a diagnosis of disseminated hydatid cyst disease. The patient was managed medically and surgically by a multidisciplinary team.\n                    <ns3:bold>Conclusion:<\/ns3:bold>\n                    Disseminated hydatid cyst disease, though rare, presents complex diagnostic and management challenges. Timely recognition, supported by clinical, radiological, and serological assessments, is essential. Surgical intervention should be considered in a patient when multiple extrahepatic cysts are present, and rupture is evident, as this approach can significantly reduce patient morbidity and mitigate life-threatening complications.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.142072.2","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T10:36:59Z","timestamp":1720694219000},"page":"1492","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Disseminated hydatid cyst: Unusual presentation and therapeutic challenges"],"prefix":"10.12688","volume":"12","author":[{"given":"Anas","family":"Mohamed Babiker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7983-422X","authenticated-orcid":false,"given":"Amro","family":"Abdelrahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5999-7948","authenticated-orcid":false,"given":"Asmaa","family":"Abdalkarim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gufran","family":"Algaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Sanosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elhassan","family":"Mohamed Abdalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-7088","authenticated-orcid":false,"given":"Hany A","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moayad","family":"Elgassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4645-2455","authenticated-orcid":false,"given":"Muhnad","family":"Abdeen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8454-132X","authenticated-orcid":false,"given":"Mohamed","family":"Elgassim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"878-882","DOI":"10.3201\/eid1306.061074","article-title":"Human alveolar echinococcosis after fox population increase, Switzerland.","volume":"13","author":"A Schweiger","year":"2007","journal-title":"Emerg. 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Case Rep."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"56-64","DOI":"10.5144\/0256-4947.2002.56","article-title":"Hydatid disease: current status and recent advances.","volume":"22","author":"M Khuroo","year":"2002","journal-title":"Ann. Saudi Med."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e6564","DOI":"10.7759\/cureus.6564","article-title":"Disseminated Hydatid Disease in a Child Involving Multiple Organ Systems: A Case Report.","volume":"12","author":"M Shabbir","year":"2020","journal-title":"Cureus."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4679-4680","DOI":"10.1128\/JCM.38.12.4679-4680.2000","article-title":"Acute echinococcosis: a case report.","volume":"38","author":"G Di Comite","year":"2000","journal-title":"J. Clin. Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"692-707","DOI":"10.2214\/ajr.122.4.692","article-title":"Hydatid disease of the lungs. A roentgenologic study of 50 cases.","volume":"122","author":"J Balikian","year":"1974","journal-title":"Am. J. Roentgenol. Radium Therapy, Nucl. Med."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"795-817","DOI":"10.1148\/radiographics.20.3.g00ma06795","article-title":"Hydatid disease: radiologic and pathologic features and complications.","volume":"20","author":"I Pedrosa","year":"2000","journal-title":"Radiographics."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"351-354","DOI":"10.1055\/s-0042-1742416","article-title":"Cystic Echinococcosis of Liver and Spleen Communicating to the Lung: A Rare Case.","volume":"14","author":"J Kalita","year":"2022","journal-title":"J Lab Physicians."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"8867744","DOI":"10.1155\/2020\/8867744","article-title":"Clinical Characteristics and Management of the Hydatid Cyst of the Liver: A Study from a Tertiary Care Center in Nepal.","volume":"2020","author":"U Joshi","year":"2020","journal-title":"J. Parasitol. 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Thanks for feedback. We will add that pan ct was recommended to look for other cystic involvemen in othe organs.  We will correct the figure issue.  We will add differential diagnosis in case presentation  Thanks again,","URL":"https:\/\/f1000research.com\/articles\/12-1492\/v2#referee-comment-11331","order":4,"name":"referee-comment-11331","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Open Access funding provided by Qatar National Library. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}