{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T03:27:25Z","timestamp":1777519645078,"version":"3.51.4"},"update-to":[{"DOI":"10.12688\/f1000research.14227.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000}}],"reference-count":63,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Mediator Complex Subunit 12 (MED12) is part of the transcriptional preinitiation machinery. Mutations of its gene predominantly occur in two types of highly frequent benign tumors, uterine leiomyomas and fibroadenomas of the breast, where they apparently act as driver mutations. Nevertheless, their presence is not restricted to benign tumors having been found at considerable frequencies in uterine leiomyosarcomas, malignant phyllodes tumors, and chronic lymphocytic leukemia also. Most of the mutations are located within exon 2 of the gene but in rare cases the intron 1\/exon 2 boundary or exon 1 are affected. As to their type, predominantly single nucleotide exchanges with a hotspot in one codon are found, but small deletions clustering around that hotspot also are not uncommon. These latter deletions are leaving the open reading frame intact. As to the types of mutations, so far no apparent differences between the tumor entities affected have emerged. Interestingly, this pattern with small deletions clustered around the hotspot of single nucleotide exchanges resembles that seen as a result of targeted gene editing. In contrast to other driver mutations the percentage of\n                    <ns4:italic>MED12<\/ns4:italic>\n                    -mutation positive tumors of independent clonal origin increases with the number of tumors per patient suggesting unknown etiological factors supporting site specific mutagenesis. \u00a0These factors may act by inducing simultaneous site-specific double strand breaks the erroneous repair of which may lead to corresponding mutations. As inducers of DNA damage and its repair such as foreign nucleic acids of the microbiome displaying sequence homology to the putative target site might play a role. Interestingly, a 16 base pair homology of the hotspot to a putative terminator base-paired hairpin sequence of a Staphylococcus aureus tRNA gene cluster has been noted which might form R-loop like structures with its target sequence thus inducing said changes.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.14227.2","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T13:48:23Z","timestamp":1544708903000},"page":"359","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Factors targeting MED12 to drive tumorigenesis?"],"prefix":"10.12688","volume":"7","author":[{"given":"J\u00f6rn","family":"Bullerdiek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"439-443","DOI":"10.1038\/nsmb.3395","article-title":"DNA-RNA hybrids: the risks of DNA breakage during transcription.","volume":"24","author":"A Aguilera","year":"2017","journal-title":"Nat Struct Mol Biol."},{"key":"ref-53","doi-asserted-by":"publisher","first-page":"247-50","DOI":"10.1097\/01.EDE.0000054360.61254.27","article-title":"Why is parity protective for uterine fibroids?","volume":"14","author":"D Baird","year":"2003","journal-title":"Epidemiology."},{"key":"ref-54","doi-asserted-by":"publisher","first-page":"208","DOI":"10.3389\/fimmu.2018.00208","article-title":"Uterine Microbiota: Residents, Tourists, or Invaders?","volume":"9","author":"J Baker","year":"2018","journal-title":"Front Immunol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1471-2350-9-20","article-title":"The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency.","volume":"9","author":"J Bayley","year":"2008","journal-title":"BMC Med Genet."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"34762-34772","DOI":"10.18632\/oncotarget.16711","article-title":"Factors affecting the loss of MED12-mutated leiomyoma cells during in vitro growth.","volume":"8","author":"J Bloch","year":"2017","journal-title":"Oncotarget."},{"key":"ref-55","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/(SICI)1098-2264(199910)26:2<181::AID-GCC12>3.0.CO;2-2","article-title":"Leiomyoma--do viruses play the main role?","volume":"26","author":"J Bullerdiek","year":"1999","journal-title":"Genes Chromosomes Cancer."},{"key":"ref-56","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/s41467-017-00901-0","article-title":"The microbiota continuum along the female reproductive tract and its relation to uterine-related diseases.","volume":"8","author":"C Chen","year":"2017","journal-title":"Nat Commun."},{"key":"ref-57","doi-asserted-by":"publisher","first-page":"593-615","DOI":"10.1093\/humupd\/dmv030","article-title":"Epidemiological and genetic clues for molecular mechanisms involved in uterine leiomyoma development and growth.","volume":"21","author":"A Commandeur","year":"2015","journal-title":"Hum Reprod Update."},{"key":"ref-4","doi-asserted-by":"publisher","first-page":"495-500","DOI":"10.1016\/S1074-3804(05)60610-X","article-title":"Recurrence of leiomyomata after laparoscopic myomectomy.","volume":"8","author":"V Doridot","year":"2001","journal-title":"J Am Assoc Gynecol Laparosc."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"15788-15793","DOI":"10.1073\/pnas.0607483103","article-title":"The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II.","volume":"103","author":"H Elmlund","year":"2006","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"595-602","DOI":"10.1093\/humupd\/6.6.595","article-title":"Recurrence of leiomyomata after myomectomy.","volume":"6","author":"A Fauconnier","year":"2000","journal-title":"Hum Reprod Update."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"257-267","DOI":"10.1159\/000337292","article-title":"Soft tissue tumors in palaeopathology: a review.","volume":"79","author":"G Fornaciari","year":"2012","journal-title":"Pathobiology."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"1-6","DOI":"10.1007\/s00294-018-0806-z","article-title":"R-loops: targets for nuclease cleavage and repeat instability.","author":"C Freudenreich","year":"2018","journal-title":"Curr Genet."},{"key":"ref-9","doi-asserted-by":"publisher","first-page":"5091-5096","DOI":"10.1128\/jb.175.16.5091-5096.1993","article-title":"Staphylococcus aureus has clustered tRNA genes.","volume":"175","author":"C Green","year":"1993","journal-title":"J Bacteriol."},{"key":"ref-10","doi-asserted-by":"publisher","first-page":"2110-2117","DOI":"10.1182\/blood-2015-05-647578","article-title":"Presence of multiple recurrent mutations confers poor trial outcome of relapsed\/refractory CLL.","volume":"126","author":"R Gui\u00e8ze","year":"2015","journal-title":"Blood."},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1038\/s41598-017-01199-0","article-title":"Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas.","volume":"7","author":"H Heinonen","year":"2017","journal-title":"Sci Rep."},{"key":"ref-12","first-page":"6445-6456","article-title":"Patterns of Chromosomal Abnormalities that Can Improve Diagnosis of Uterine Smooth Muscle Tumors.","volume":"35","author":"C Holzmann","year":"2015","journal-title":"Anticancer Res."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"1761-1765","DOI":"10.1038\/bjc.2012.428","article-title":"Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.","volume":"107","author":"K K\u00e4mpj\u00e4rvi","year":"2012","journal-title":"Br J Cancer."},{"key":"ref-14","doi-asserted-by":"publisher","first-page":"1884-1888","DOI":"10.18632\/oncotarget.2753","article-title":"Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia.","volume":"6","author":"K K\u00e4mpj\u00e4rvi","year":"2015","journal-title":"Oncotarget."},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"1405-1411","DOI":"10.1038\/bjc.2016.130","article-title":"MED12 mutations and FH inactivation are mutually exclusive in uterine leiomyomas.","volume":"114","author":"K K\u00e4mpj\u00e4rvi","year":"2016","journal-title":"Br J Cancer."},{"key":"ref-16","doi-asserted-by":"publisher","first-page":"333-339","DOI":"10.1038\/nature12634","article-title":"Mutational landscape and significance across 12 major cancer types.","volume":"502","author":"C Kandoth","year":"2013","journal-title":"Nature."},{"key":"ref-17","doi-asserted-by":"publisher","first-page":"204-217","DOI":"10.1055\/s-0030-1251477","article-title":"New directions in the epidemiology of uterine fibroids.","volume":"28","author":"S Laughlin","year":"2010","journal-title":"Semin Reprod Med."},{"key":"ref-18","doi-asserted-by":"publisher","DOI":"10.1038\/srep16814","article-title":"Circulating microbial RNA and health.","volume":"5","author":"R Leung","year":"2015","journal-title":"Sci Rep."},{"key":"ref-19","doi-asserted-by":"publisher","first-page":"877-880","DOI":"10.1038\/ng.3037","article-title":"Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.","volume":"46","author":"W Lim","year":"2014","journal-title":"Nat Genet."},{"key":"ref-20","doi-asserted-by":"publisher","first-page":"252-255","DOI":"10.1126\/science.1208930","article-title":"MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.","volume":"334","author":"N M\u00e4kinen","year":"2011","journal-title":"Science."},{"key":"ref-21","doi-asserted-by":"publisher","first-page":"1528-1536","DOI":"10.1002\/ijc.27424","article-title":"MED12 mutations in uterine fibroids--their relationship to cytogenetic subgroups.","volume":"131","author":"D Markowski","year":"2012","journal-title":"Int J Cancer."},{"key":"ref-22","doi-asserted-by":"publisher","first-page":"297-304","DOI":"10.1002\/gcc.22029","article-title":"MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors.","volume":"52","author":"D Markowski","year":"2013a","journal-title":"Genes Chromosomes Cancer."},{"key":"ref-23","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1755-8166-6-23","article-title":"Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability.","volume":"6","author":"D Markowski","year":"2013b","journal-title":"Mol Cytogenet."},{"key":"ref-24","doi-asserted-by":"publisher","first-page":"568-572","DOI":"10.1097\/PGP.0000000000000096","article-title":"Uterine fibroids: do we deal with more than one disease?","volume":"33","author":"D Markowski","year":"2014a","journal-title":"Int J Gyn Path."},{"key":"ref-25","doi-asserted-by":"publisher","first-page":"317-323","DOI":"10.1002\/gcc.22142","article-title":"Cell cultures in uterine leiomyomas: rapid disappearance of cells carrying MED12 mutations.","volume":"53","author":"D Markowski","year":"2014b","journal-title":"Genes Chromosomes Cancer."},{"key":"ref-26","doi-asserted-by":"publisher","first-page":"1-6","DOI":"10.1002\/gcc.2870110102","article-title":"Analysis of androgen receptor DNA reveals the independent clonal origins of uterine leiomyomata and the secondary nature of cytogenetic aberrations in the development of leiomyomata.","volume":"11","author":"R Mashal","year":"1994","journal-title":"Genes Chromosomes Cancer."},{"key":"ref-27","doi-asserted-by":"publisher","first-page":"e33251","DOI":"10.1371\/journal.pone.0033251","article-title":"Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.","volume":"7","author":"M McGuire","year":"2012","journal-title":"PLoS One."},{"key":"ref-28","doi-asserted-by":"publisher","first-page":"181-189","DOI":"10.1055\/s-0037-1599090","article-title":"Recent Advances in Uterine Fibroid Etiology.","volume":"35","author":"M McWilliams","year":"2017","journal-title":"Semin Reprod Med."},{"key":"ref-29","doi-asserted-by":"publisher","first-page":"43-53","DOI":"10.1056\/NEJMoa1302736","article-title":"Characterization of uterine leiomyomas by whole-genome sequencing.","volume":"369","author":"M Mehine","year":"2013","journal-title":"N Engl J Med."},{"key":"ref-30","doi-asserted-by":"publisher","first-page":"4407-4416","DOI":"10.1093\/hmg\/ddv177","article-title":"Clonally related uterine leiomyomas are common and display branched tumor evolution.","volume":"24","author":"M Mehine","year":"2015","journal-title":"Hum Mol Genet."},{"key":"ref-31","doi-asserted-by":"publisher","first-page":"S17-29","DOI":"10.1038\/modpathol.2013.178","article-title":"Smooth muscle tumors of soft tissue and non-uterine viscera: biology and prognosis.","volume":"27","author":"M Miettinen","year":"2014","journal-title":"Mod Pathol."},{"key":"ref-32","doi-asserted-by":"publisher","first-page":"305-312","DOI":"10.1007\/s10549-015-3469-1","article-title":"Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.","volume":"152","author":"C Mishima","year":"2015","journal-title":"Breast Cancer Res Treat."},{"key":"ref-33","doi-asserted-by":"publisher","first-page":"489-495","DOI":"10.1089\/jwh.2014.5051","article-title":"Self-Reported Reproductive Tract Infections and Ultrasound Diagnosed Uterine Fibroids in African-American Women.","volume":"24","author":"K Moore","year":"2015","journal-title":"J Womens Health (Larchmt)."},{"key":"ref-34","doi-asserted-by":"publisher","first-page":"961-968","DOI":"10.1093\/aje\/kwv313","article-title":"Herpes Simplex Virus Type 2 Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.","volume":"183","author":"K Moore","year":"2016","journal-title":"Am J Epidemiol."},{"key":"ref-35","doi-asserted-by":"publisher","first-page":"278-286","DOI":"10.1093\/aje\/kwx231","article-title":"Chlamydia trachomatis Seroprevalence and Ultrasound-Diagnosed Uterine Fibroids in a Large Population of Young African-American Women.","volume":"187","author":"K Moore","year":"2018","journal-title":"Am J Epidemiol."},{"key":"ref-36","doi-asserted-by":"publisher","first-page":"1117-1121","DOI":"10.1002\/cam4.462","article-title":"MED12 exon 2 mutations in phyllodes tumors of the breast.","volume":"4","author":"S Nagasawa","year":"2015","journal-title":"Cancer Med."},{"key":"ref-37","doi-asserted-by":"publisher","first-page":"685-691","DOI":"10.1136\/jclinpath-2015-202896","article-title":"MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.","volume":"68","author":"C Ng","year":"2015","journal-title":"J Clin Pathol."},{"key":"ref-38","doi-asserted-by":"publisher","first-page":"125-129","DOI":"10.1038\/nature17664","article-title":"Efficient introduction of specific homozygous and heterozygous mutations using CRISPR\/Cas9.","volume":"533","author":"D Paquet","year":"2016","journal-title":"Nature."},{"key":"ref-58","doi-asserted-by":"publisher","first-page":"21541-51","DOI":"10.18632\/oncotarget.25059","article-title":"The fallopian tube microbiome: implications for reproductive health","volume":"9","author":"E Pelzer","year":"2018","journal-title":"Oncotarget."},{"key":"ref-39","doi-asserted-by":"publisher","first-page":"e40015","DOI":"10.1371\/journal.pone.0040015","article-title":"MED12 alterations in both human benign and malignant uterine soft tissue tumors.","volume":"7","author":"G P\u00e9rot","year":"2012","journal-title":"PLoS One."},{"key":"ref-40","doi-asserted-by":"publisher","first-page":"444-52","DOI":"10.1002\/gcc.22256","article-title":"Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.","volume":"54","author":"N Pfarr","year":"2015","journal-title":"Genes Chromosomes Cancer."},{"key":"ref-41","doi-asserted-by":"publisher","first-page":"719-729","DOI":"10.1111\/his.12712","article-title":"MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.","volume":"67","author":"S Piscuoglio","year":"2015","journal-title":"Histopathology."},{"key":"ref-42","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/561548","article-title":"AIDS-Related EBV-Associated Smooth Muscle Tumors: A Review of 64 Published Cases.","volume":"2011","author":"B Purgina","year":"2011","journal-title":"Patholog Res Int."},{"key":"ref-43","doi-asserted-by":"publisher","first-page":"1122-1134","DOI":"10.1111\/j.1365-2559.2011.04049.x","article-title":"Extra-uterine myoid tumours in patients with acquired immunodeficiency syndrome: A clinicopathological reappraisal.","volume":"59","author":"P Ramdial","year":"2011","journal-title":"Histopathology."},{"key":"ref-59","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.3389\/fmicb.2017.01354","article-title":"Intracellular Survival of Staphylococcus aureus in Endothelial Cells: A Matter of Growth or Persistence.","volume":"8","author":"G Rollin","year":"2017","journal-title":"Front Microbiol."},{"key":"ref-44","doi-asserted-by":"publisher","first-page":"436-444","DOI":"10.1038\/ng0895-436","article-title":"Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours.","volume":"10","author":"E Schoenmakers","year":"1995","journal-title":"Nat Genet."},{"key":"ref-60","doi-asserted-by":"publisher","first-page":"54-8","DOI":"10.1016\/j.tim.2008.11.004","article-title":"Staphylococcus aureus as an intracellular pathogen: the role of small colony variants.","volume":"17","author":"P Sendi","year":"2009","journal-title":"Trends Microbiol."},{"key":"ref-45","doi-asserted-by":"publisher","first-page":"E8392-E8401","DOI":"10.1073\/pnas.1711283114","article-title":"Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.","volume":"114","author":"X Su","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"key":"ref-61","doi-asserted-by":"publisher","first-page":"11997","DOI":"10.1038\/srep11997","article-title":"Transcriptome analysis of the biofilm formed by methicillin-susceptible Staphylococcus aureus.","volume":"5","author":"X Tan","year":"2015","journal-title":"Sci Rep."},{"key":"ref-62","doi-asserted-by":"publisher","first-page":"1068-78","DOI":"10.1093\/carcin\/bgy073","article-title":"Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.","volume":"39","author":"R Thomas","year":"2018","journal-title":"Carcinogenesis."},{"key":"ref-63","doi-asserted-by":"publisher","first-page":"5039-48","DOI":"10.1128\/AEM.01235-16","article-title":"The Microbiota of Breast Tissue and Its Association with Breast Cancer","volume":"82","author":"C Urbaniak","year":"2016","journal-title":"Appl Environ Microbiol."},{"key":"ref-46","doi-asserted-by":"publisher","first-page":"1546-1558","DOI":"10.1126\/science.1235122","article-title":"Cancer genome landscapes.","volume":"339","author":"B Vogelstein","year":"2013","journal-title":"Science."},{"key":"ref-47","doi-asserted-by":"publisher","first-page":"e51009","DOI":"10.1371\/journal.pone.0051009","article-title":"The complex exogenous RNA spectra in human plasma: an interface with human gut biota?","volume":"7","author":"K Wang","year":"2012","journal-title":"PLoS One."},{"key":"ref-48","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.12688\/f1000research.12172.1","article-title":"Uterine fibroids \u2013 what\u2019s new? [version 1; referees: 3 approved].","volume":"6","author":"A Williams","year":"2017","journal-title":"F1000Res."},{"key":"ref-49","first-page":"57-61","article-title":"The etiology of uterine fibroids with special reference to the frequency of their occurrence in the Negro: an hypothesis.","volume":"58","author":"J Witherspoon","year":"1934","journal-title":"Surg Gynecol Obstet."},{"key":"ref-50","doi-asserted-by":"publisher","first-page":"421-429","DOI":"10.1111\/bjh.14869","article-title":"MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.","volume":"179","author":"B Wu","year":"2017a","journal-title":"Br J Haematol."},{"key":"ref-51","doi-asserted-by":"publisher","first-page":"6891-6901","DOI":"10.1158\/0008-5472.CAN-17-1744","article-title":"Subtype-Specific Tumor-Associated Fibroblasts Contribute to the Pathogenesis of Uterine Leiomyoma.","volume":"77","author":"X Wu","year":"2017b","journal-title":"Cancer Res."},{"key":"ref-52","doi-asserted-by":"publisher","first-page":"1703-1708","DOI":"10.1038\/bjc.2015.116","article-title":"Frequent MED12 mutations in phyllodes tumours of the breast.","volume":"112","author":"M Yoshida","year":"2015","journal-title":"Br J Cancer."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/7-359\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-359\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-359\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T04:56:13Z","timestamp":1546923373000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/7-359\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":63,"URL":"https:\/\/doi.org\/10.12688\/f1000research.14227.2","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.18776.r41939","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.18776.r41940","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.18776.r41939","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,13]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/7-359\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.18776.r41939, Takeshi Kurita, Departmentof\u00a0Cancer Biology\u00a0and\u00a0Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA, 08 Jan 2019, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/7-359\/v2#referee-response-41939","order":0,"name":"referee-response-41939","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15482.r34711, Eric Glasgow, Department of Oncology, Georgetown University, Washington, DC, USA, 19 Jun 2018, version 1, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/7-359\/v1#referee-response-34711","order":1,"name":"referee-response-34711","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15482.r36051, Jose M. Teixeira, Department\u00a0of\u00a0Obstetrics,\u00a0Gynecology\u00a0and\u00a0Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA, 31 Jul 2018, version 1, 3 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/7-359\/v1#referee-response-36051","order":2,"name":"referee-response-36051","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}