{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:02Z","timestamp":1772168822741,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.143189.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000}},{"DOI":"10.12688\/f1000research.143189.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000}}],"reference-count":47,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Cerebral palsy (CP) is a neurological disorder that can affect motor skills and psychophysiological well-being. Virtual Reality Exercise (VRE) improves cognitive and physical outcomes in patients with CP. Therefore, this study aimed to investigate the effects of VRE on attention, vigor, and decision-making abilities in adolescents with CP. Methods A randomized controlled trial was conducted. The intervention consisted of a single 40-minute session of VRE compared to TE conducted in a controlled laboratory environment. Results Fourteen participants (42.9 % female) were included in this analysis. The results indicated that VRE had a statistically significant positive effect on attention and vigor compared to TE. While participants in the VRE group exhibited enhanced attention levels and reported elevated levels of vigor subsequent to the exercise sessions, the memory results did not reach statistical significance. Conclusions The findings suggest that VRE is an effective intervention for improving attention and vigor in adolescents with CP. Registration Pan African Clinical Trial Registry (PACTR202308598603482; 31\/08\/2023). The trial was reported in accordance with the CONSORT reporting guidelines.<\/ns3:p>","DOI":"10.12688\/f1000research.143189.3","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T14:05:06Z","timestamp":1752847506000},"page":"1597","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute effects of virtual reality exercise bike games on psychophysiological outcomes in college North-African adolescents with cerebral palsy: A randomized clinical trial"],"prefix":"10.12688","volume":"12","author":[{"given":"Makrem","family":"Soudani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faical","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2851-0753","authenticated-orcid":false,"given":"Amine","family":"Ghram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-2965","authenticated-orcid":false,"given":"Helmi","family":"Ben Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Chlif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"ref1","first-page":"8-14","article-title":"A report: the 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Furthermore, authors should improve the format of the presentation, suggesting having an example of a published RCT paper to follow.<\/i> \n<b>Response:<\/b> We appreciate your feedback regarding our manuscript. We recognize the necessity for a more precise intervention design and consulted well-structured randomized controlled trial (RCT) papers to enhance the format and presentation of our work. Furthermore, we meticulously revised the intervention description to ensure adherence to the standard RCT formats. \n<b>Action Taken:<\/b> The intervention section has been revised to adhere to a more structured format commonly used in published randomized controlled trials (RCTs). This revision encompasses a clear delineation of the study design, intervention details, and outcome measures to enhance the methodological clarity and rigor. \n<b>Reviewer Comment 2:<\/b> \n<i>Abstract not clear because of no information about the intervention such as weeks.<\/i> \n<b>Response:<\/b> We acknowledge your observation and have subsequently revised the abstract to incorporate specific details regarding intervention duration, thereby ensuring comprehensive information about the study's structure for readers. \n<b>Action Taken:<\/b> The abstract now incorporates the following information (Lines 30\u201332): &quot;\n<b>The intervention consisted of a single 40-minute session of virtual reality exercise (VRE) compared to traditional exercise (TE), conducted in a controlled laboratory environment<\/b>\n<b>.<\/b>&quot; This addition provided essential details regarding the intervention and enhanced the comprehensiveness of the abstract.   \n<b>Reviewer Comment 3:<\/b> \n<i>Introduction not read because method is very confusing.<\/i> \n<b>Response:<\/b> We acknowledge the ambiguity engendered by the initial organization of the methods section. To rectify this issue, we have restructured both the Introduction and Methods sections to enhance the clarity and logical progression. \n<b>Action Taken:<\/b> The Introduction has been revised to ensure enhanced alignment with the study's methodology and objectives. Furthermore, the Methods section provides a comprehensive, sequential explanation of the intervention and study design, thereby minimizing potential ambiguities. \n<b>Reviewer Comment 4:<\/b> \n<i>Method: - Ethics considerations have been already mentioned in the design, so it would be unnecessary to repeat. - Randomization should be part of design, not a separate paragraph.<\/i> \n<b>Response:<\/b> We would like to acknowledge this recommendation. Redundant ethical considerations were eliminated, and the randomization process was integrated into the study design section to enhance the coherence of the presentation. \n<b>Action Taken:<\/b> The randomization protocol has been relocated to the design section (lines 175\u2013176), and superfluous ethical considerations have been eliminated to enhance conciseness and clarity.  \n<b>Reviewer Comment 5:<\/b> \n<i>Method: Even this study has been registered, authors still need to provide information about design, such as training and outcomes, etc.<\/i> \n<b>Response:<\/b> We acknowledge your observation and have provided supplementary information concerning the study design, encompassing training protocols and specific outcomes. \n<b>Action Taken:<\/b> The Methods section now delineates the training regimen, outcome measures, and data collection processes, thereby ensuring that the study design is fully transparent and adheres to RCT guidelines.  \n<b>Reviewer Comment 6:<\/b> \n<i>Methods: Figure 1 - Authors should show how many weeks of intervention as well as a brief content for both groups.<\/i> \n<b>Response:<\/b> Thank you for your suggestion. The intervention duration was clarified, and a concise description of the intervention for both groups was provided (Figure 1). \n<b>Action Taken:<\/b> Figure 1 demonstrates that the intervention was implemented as a single-session trial and a concise description of the intervention protocols for both groups was provided.  \n<b>Reviewer Comment 7:<\/b> \n<i>Methods: participants - Should use \u201cParticipants\u201d to replace \u201cPatients\u201d. - Actual number of participants and characteristics should be in the results.<\/i> \n<b>Response:<\/b> We agree with the reviewer's recommendations. The term &quot;participants&quot; has been substituted for &quot;patients&quot; throughout the manuscript, and the precise number of participants, along with their demographic characteristics, has been moved to the Results section. \n<b>Action Taken:<\/b> The term &quot;patients&quot; has been replaced with &quot;participants&quot; throughout the manuscript, and the characteristics of participants have been incorporated into the results section (Lines 301, Table 1).  \n<b>Reviewer Comment 8:<\/b> \n<i>Methods: Intervention - This is the main problem because it\u2019s hard to believe it will be effective for only two times training.<\/i> \n<b>Response:<\/b> This study has several limitations. While the present investigation focused on the immediate effects of a single session, further studies are necessary to assess the long-term impact of repeated interventions. This limitation has been addressed in the Discussion section. \n<b>Action Taken:<\/b> This study acknowledges this limitation and suggests that future research should incorporate extended interventions to evaluate the cumulative effects of repeated VRE sessions.  \n<b>Reviewer Comment 9:<\/b> \n<i>Results: Table 1 (missing). Characteristics of participants.<\/i> \n<b>Response:&nbsp;<\/b>We acknowledge your observation and have subsequently incorporated Table 1, which delineates the participants' characteristics including age, sex, and pertinent demographic data. \n<b>Action Taken:&nbsp;<\/b>Table 1 has been incorporated into the Results section, presenting the characteristics of the study participants as requested.  \n<b>Reviewer Comment 10:<\/b> \n<i>Results: Table 2 (missing). Differences between groups in all outcomes across times.<\/i> \n<b>Response:&nbsp;<\/b>Table 2 presents the differences between the groups across all outcome measures and time points. \n<b>Action Taken:&nbsp;<\/b>Table 2 has been added to the Results section to show the differences in outcomes between the traditional exercise and VRE groups.  \n<b>Reviewer Comment 11:<\/b> \n<i>The discussion and conclusion have not been read because the method and results are unstructured.<\/i> \n<b>Response:&nbsp;<\/b>The Methods and Results sections have been restructured to enhance the clarity and logical progression. The discussion has been aligned to provide a coherent narrative that establishes connections among the methods, results, and conclusions. \n<b>Action Taken:&nbsp;<\/b>The Methods, Results, and Discussion sections were restructured to enhance clarity, thereby improving the accessibility and logical organization of the manuscript.  \n<b>Reviewer Comment 12:<\/b> \n<i>This paper is not easy to read because of unstructured format and fluency of English.<\/i> \n<b>Response:&nbsp;<\/b>The authors acknowledge concerns regarding readability and fluency. The manuscript has undergone a comprehensive revision to enhance both the structure and fluency of the English language, thereby ensuring a more lucid and professional presentation. \n<b>Action Taken:&nbsp;<\/b>The manuscript has undergone comprehensive revision to enhance clarity, grammatical accuracy, and overall fluency, thereby improving readability while maintaining scholarly rigor. Thank you for your valuable feedback. We believe that these revisions have significantly improved the clarity, structure, and scientific rigor of our manuscript. We look forward to your feedback, and hope that the revised manuscript meets your expectations.","URL":"https:\/\/f1000research.com\/articles\/12-1597\/v3#referee-comment-12676","order":2,"name":"referee-comment-12676","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.173736.r349413, Taha Yassine Temlali, Radboud University, Nijmegen, 17 Jan 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/12-1597\/v2#referee-response-349413","order":3,"name":"referee-response-349413","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This study was supported by the Qatar National Library. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}