{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:28:52Z","timestamp":1785169732943,"version":"3.55.0"},"update-to":[{"DOI":"10.12688\/f1000research.143514.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000}}],"reference-count":79,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["471606"],"award-info":[{"award-number":["471606"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Fibroblasts are cells of mesenchymal origin that are found throughout the body. While these cells have several functions, their integral roles include maintaining tissue architecture through the production of key extracellular matrix components, and participation in wound healing after injury. Fibroblasts are also key mediators in disease progression during fibrosis, cancer, and other inflammatory diseases. Under these perturbed states, fibroblasts can activate into inflammatory fibroblasts or contractile myofibroblasts. Fibroblasts require various growth factors and mitogenic molecules for survival, proliferation, and differentiation. While the activity of mitogenic growth factors on fibroblasts\n                    <ns3:italic>in vitro<\/ns3:italic>\n                    was characterized as early as the 1970s, the proliferation and differentiation effects of growth factors on these cells\n                    <ns3:italic>in vivo<\/ns3:italic>\n                    are unclear. Recent work exploring the heterogeneity of fibroblasts raises questions as to whether all fibroblast cell states exhibit the same growth factor requirements. Here, we will examine and review existing studies on the influence of fibroblast growth factor receptors (FGFRs), platelet-derived growth factor receptors (PDGFRs), and transforming growth factor \u03b2 receptor (TGF\u03b2R) on fibroblast cell states.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.143514.2","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T09:55:06Z","timestamp":1716285306000},"page":"120","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor \u03b2 Receptor (TGF\u03b2R)"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-622X","authenticated-orcid":false,"given":"Maye F.","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9775-4015","authenticated-orcid":false,"given":"Faizah S.","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-622X","authenticated-orcid":false,"given":"Matthew B.","family":"Buechler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3852-3872","DOI":"10.1016\/j.cell.2021.06.024","article-title":"Fibroblasts: Origins, definitions, and functions in health and disease.","volume":"184","author":"M Plikus","year":"2021","journal-title":"Cell."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"43-55","DOI":"10.1146\/annurev-cancerbio-061421-035400","article-title":"Cancer-Associated Fibroblasts: Lessons from Pancreatic Cancer.","volume":"7","author":"M Sherman","year":"2023","journal-title":"Annu. Rev. Cancer Biol."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"575-579","DOI":"10.1038\/s41586-021-03549-5","article-title":"Cross-tissue organization of the fibroblast lineage.","volume":"593","author":"M Buechler","year":"2021","journal-title":"Nature."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"203-219","DOI":"10.4161\/cam.20377","article-title":"The role of the myofibroblast in tumor stroma remodeling.","volume":"6","author":"M Otranto","year":"2012","journal-title":"Cell Adhes. Migr."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e0145235","DOI":"10.1371\/journal.pone.0145235","article-title":"Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins.","volume":"10","author":"C Janmaat","year":"2015","journal-title":"PLoS One."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1038\/s41467-020-17740-1","article-title":"Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination.","volume":"11","author":"L Muhl","year":"2020","journal-title":"Nat. Commun."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"609653","DOI":"10.3389\/fbioe.2020.609653","article-title":"Mechanical and Physical Regulation of Fibroblast\u2013Myofibroblast Transition: From Cellular Mechanoresponse to Tissue Pathology.","volume":"8","author":"M D\u2019Urso","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00716-0","article-title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis.","volume":"1\u201322","author":"F Younesi","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1038\/s41467-019-09728-3","article-title":"Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.","volume":"10","author":"H Cheng","year":"2019","journal-title":"Nat. Commun."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"510-519","DOI":"10.1038\/s41590-021-00894-5","article-title":"Fibroblastic reticular cell lineage convergence in Peyer\u2019s patches governs intestinal immunity.","volume":"22","author":"A Prados","year":"2021","journal-title":"Nat. Immunol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"eabj0641","DOI":"10.1126\/sciimmunol.abj0641","article-title":"A diverse fibroblastic stromal cell landscape in the spleen directs tissue homeostasis and immunity.","volume":"7","author":"Y Alexandre","year":"2022","journal-title":"Sci. Immunol."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00441-008-0729-y","article-title":"Gene and microRNA expression signatures of human mesenchymal stromal cells in comparison to fibroblasts.","volume":"335","author":"S Bae","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"85-97","DOI":"10.1159\/000445096","article-title":"Fibroblasts and Mesenchymal Stromal\/Stem Cells Are Phenotypically Indistinguishable.","volume":"136","author":"R Denu","year":"2016","journal-title":"Acta Haematol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1270493","DOI":"10.3389\/fimmu.2023.1270493","article-title":"Comparative computational analysis to distinguish mesenchymal stem cells from fibroblasts.","volume":"14","author":"B Budeus","year":"2023","journal-title":"Front. Immunol."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.798331","article-title":"Single-Cell Transcriptome Integration Analysis Reveals the Correlation Between Mesenchymal Stromal Cells and Fibroblasts.","volume":"13","author":"C Fan","year":"2022","journal-title":"Front. Genet."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2195-2205.e5","DOI":"10.1016\/j.devcel.2023.08.003","article-title":"Control of murine brown adipocyte development by GATA6.","volume":"58","author":"S Jun","year":"2023","journal-title":"Dev. Cell."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1642-1655","DOI":"10.1038\/cdd.2014.80","article-title":"A novel PPAR\u03b32 modulator sLZIP controls the balance between adipogenesis and osteogenesis during mesenchymal stem cell differentiation.","volume":"21","author":"J Kim","year":"2014","journal-title":"Cell Death Differ."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1138-1148","DOI":"10.1038\/s41590-023-01502-4","article-title":"PI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.","volume":"24","author":"A Martin","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1149-1160","DOI":"10.1038\/s41590-023-01503-3","article-title":"Conserved stromal\u2013immune cell circuits secure B cell homeostasis and function.","volume":"24","author":"M L\u00fctge","year":"2023","journal-title":"Nat. Immunol."},{"key":"ref20","article-title":"Physiology, Growth Factor.","author":"W Stone","year":"2023","journal-title":"StatPearls."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3389\/fendo.2020.00384","article-title":"Growth Factors in Regeneration and Regenerative Medicine: \u201cthe Cure and the Cause.\u201d.","volume":"11","author":"K Kulebyakin","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"153-162","DOI":"10.1111\/j.1524-475X.2009.00466.x","article-title":"Interactions between extracellular matrix and growth factors in wound healing.","volume":"17","author":"G Schultz","year":"2009","journal-title":"Wound Repair Regen."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"a004952","DOI":"10.1101\/cshperspect.a004952","article-title":"Heparan Sulfate Proteoglycans.","volume":"3","author":"S Sarrazin","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3390\/ijms19071875","article-title":"FGF Family: From Drug Development to Clinical Application.","volume":"19","author":"Q Hui","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"10262","DOI":"10.1038\/ncomms10262","article-title":"Mechanism of FGF receptor dimerization and activation.","volume":"7","author":"S Sarabipour","year":"2016","journal-title":"Nat. Commun."},{"key":"ref26","doi-asserted-by":"publisher","first-page":"711-717","DOI":"10.1016\/j.molcel.2006.01.022","article-title":"Autophosphorylation of FGFR1 Kinase Is Mediated by a Sequential and Precisely Ordered Reaction.","volume":"21","author":"C Furdui","year":"2006","journal-title":"Mol. Cell."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1646-1647","DOI":"10.1126\/science.1071809","article-title":"Signal Transduction by the TGF-\u03b2 Superfamily.","volume":"296","author":"L Attisano","year":"2002","journal-title":"Science."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"jcs232157","DOI":"10.1242\/jcs.232157","article-title":"Cross-talk between TGF-\u03b2 and PDGFR\u03b1 signaling pathways regulates the fate of stromal fibro\u2013adipogenic progenitors.","volume":"132","author":"O Contreras","year":"2019","journal-title":"J. Cell Sci."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/scrt32","article-title":"Growth factor regulation of proliferation and survival of multipotential stromal cells.","volume":"1","author":"M Rodrigues","year":"2010","journal-title":"Stem Cell Res. Ther."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"271-280","DOI":"10.1016\/0092-8674(91)90638-F","article-title":"Growth factors in development, transformation, and tumorigenesis.","volume":"64","author":"M Cross","year":"1991","journal-title":"Cell."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"467-481","DOI":"10.1002\/emmm.201302698","article-title":"Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion.","volume":"6","author":"S Coleman","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"3519-3528","DOI":"10.1242\/dev.120.12.3519","article-title":"FGF2 regulates proliferation of neural crest cells, with subsequent neuronal differentiation regulated by LIF or related factors.","volume":"120","author":"M Murphy","year":"1994","journal-title":"Development."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"383-393","DOI":"10.1007\/s10571-019-00738-9","article-title":"FGF2 Stimulates the Growth and Improves the Melanocytic Commitment of Trunk Neural Crest Cells.","volume":"40","author":"B Teixeira","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2922-2926","DOI":"10.1016\/j.febslet.2009.07.056","article-title":"FGF2 stimulates the proliferation of human mesenchymal stem cells through the transient activation of JNK signaling.","volume":"583","author":"H Ahn","year":"2009","journal-title":"FEBS Lett."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"72-80","DOI":"10.1016\/j.bone.2013.09.024","article-title":"FGF2 stimulates osteogenic differentiation through ERK induced TAZ expression.","volume":"58","author":"M Byun","year":"2014","journal-title":"Bone."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"4131-4148","DOI":"10.1007\/s00018-014-1678-0","article-title":"Mechanisms of endothelial cell migration.","volume":"71","author":"U Michaelis","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"360-370","DOI":"10.1016\/j.bone.2010.05.021","article-title":"Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.","volume":"47","author":"L Xiao","year":"2010","journal-title":"Bone."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"85-101","DOI":"10.1152\/physiol.00045.2009","article-title":"Roles for Growth Factors in Cancer Progression.","volume":"25","author":"E Witsch","year":"2010","journal-title":"Physiology."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3390\/cancers10020052","article-title":"The Epithelial-to-Mesenchymal Transition in Cancer.","volume":"10","author":"J Roche","year":"2018","journal-title":"Cancers."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"582-598","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer.","volume":"16","author":"R Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"123-127","DOI":"10.1038\/249123a0","article-title":"Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth.","volume":"249","author":"D Gospodarowicz","year":"1974","journal-title":"Nature."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"139-149","DOI":"10.1016\/j.cytogfr.2005.01.001","article-title":"Cellular signaling by fibroblast growth factor receptors.","volume":"16","author":"V Eswarakumar","year":"2005","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1005-1019","DOI":"10.1177\/002215549704500710","article-title":"Differential Expression of the Fibroblast Growth Factor Receptor (FGFR) Multigene Family in Normal Human Adult Tissues.","volume":"45","author":"S Hughes","year":"1996","journal-title":"J. Histochem. Cytochem."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"e13009","DOI":"10.1111\/cpr.13009","article-title":"Inhibition of FGF-FGFR and VEGF-VEGFR signalling in cancer treatment.","volume":"54","author":"G Liu","year":"2021","journal-title":"Cell Prolif."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.3390\/cells10061342","article-title":"Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling.","volume":"10","author":"P Szybowska","year":"2021","journal-title":"Cells."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"663-673","DOI":"10.1083\/jcb.200505098","article-title":"Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.","volume":"171","author":"W Xian","year":"2005","journal-title":"J. Cell Biol."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"2724-2736","DOI":"10.1002\/stem.1514","article-title":"FGFR1 Signaling Stimulates Proliferation of Human Mesenchymal Stem Cells by Inhibiting the Cyclin-Dependent Kinase Inhibitors p21Waf1 and p27Kip1.","volume":"31","author":"C Dombrowski","year":"2013","journal-title":"Stem Cells."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"E121-E131","DOI":"10.1152\/ajpendo.90602.2008","article-title":"Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes.","volume":"296","author":"C Widberg","year":"2009","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"160-170","DOI":"10.1159\/000484604","article-title":"Ablation of FGFR2 in Fibroblasts Ameliorates Kidney Fibrosis after Ischemia\/Reperfusion Injury in Mice.","volume":"3","author":"Z Xu","year":"2017","journal-title":"Kidney Dis."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"85-97","DOI":"10.1016\/j.devcel.2016.03.001","article-title":"An FGFR1-SPRY2 Signaling Axis Limits Basal Cell Proliferation in the Steady-State Airway Epithelium.","volume":"37","author":"G Balasooriya","year":"2016","journal-title":"Dev. Cell"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"3731-3742","DOI":"10.1242\/dev.037689","article-title":"FGF signalling: diverse roles during early vertebrate embryogenesis.","volume":"137","author":"K Dorey","year":"2010","journal-title":"Development."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"194-204","DOI":"10.1016\/j.mce.2017.09.015","article-title":"Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes.","volume":"461","author":"T K\u00e4hk\u00f6nen","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"303-313","DOI":"10.1016\/j.devcel.2008.12.003","article-title":"Increased PDGFR\u03b1 Activation Disrupts Connective Tissue Development and Drives Systemic Fibrosis.","volume":"16","author":"L Olson","year":"2009","journal-title":"Dev. Cell."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"H330-H344","DOI":"10.1152\/ajpheart.00054.2019","article-title":"Platelet-derived growth factor receptor-\u03b1 is essential for cardiac fibroblast survival.","volume":"317","author":"M Ivey","year":"2019","journal-title":"Am. J. Physiol.-Hear. Circ. Physiol."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"225979","DOI":"10.1101\/225979","article-title":"PDGFR\u03b1 signaling in cardiac fibroblasts modulates quiescence, metabolism and self-renewal, and promotes anatomical and functional repair.","author":"N Asli","year":"2019","journal-title":"bioRxiv."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"9375-9389","DOI":"10.1074\/jbc.M413081200","article-title":"Deletion of the PDGFR-\u03b2 Gene Affects Key Fibroblast Functions Important for Wound Healing.","volume":"280","author":"Z Gao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1186\/1478-811X-11-97","article-title":"Targeting the PDGF signaling pathway in tumor treatment.","volume":"11","author":"C Heldin","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"3385-3391","DOI":"10.3748\/wjg.v11.i22.3385","article-title":"Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells.","volume":"11","author":"A Masamune","year":"2005","journal-title":"World J. Gastroenterol."},{"key":"ref59","doi-asserted-by":"publisher","first-page":"F79-F113","DOI":"10.1016\/S0304-419X(98)00015-8","article-title":"Signal transduction via platelet-derived growth factor receptors.","volume":"1378","author":"C Heldin","year":"1998","journal-title":"Biochim. Biophys. Acta (BBA) - Rev. Cancer."},{"key":"ref60","doi-asserted-by":"publisher","first-page":"226-232","DOI":"10.1038\/323226a0","article-title":"Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors.","volume":"323","author":"Y Yarden","year":"1986","journal-title":"Nature."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"297-301","DOI":"10.1016\/0014-4827(74)90484-4","article-title":"Platelets as a source of fibroblast growth-promoting activity.","volume":"87","author":"N Kohler","year":"1974","journal-title":"Exp. Cell Res."},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2971","article-title":"Myofibroblast proliferation and heterogeneity are supported by macrophages during skin repair.","volume":"362","author":"B Shook","year":"2018","journal-title":"Science."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41419-022-04981-9","article-title":"The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis.","volume":"13","author":"J Wu","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"608-619","DOI":"10.1006\/excr.1999.4440","article-title":"Release of Mechanical Tension Triggers Apoptosis of Human Fibroblasts in a Model of Regressing Granulation Tissue.","volume":"248","author":"F Grinnell","year":"1999","journal-title":"Exp. Cell Res."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"3250-3261","DOI":"10.1096\/fj.07-8218com","article-title":"Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis.","volume":"21","author":"S Aarabi","year":"2007","journal-title":"FASEB J."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"1339-1350","DOI":"10.1084\/jem.20110551","article-title":"Integrating mechanisms of pulmonary fibrosis.","volume":"208","author":"T Wynn","year":"2011","journal-title":"J. Exp. Med."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1038\/s41419-018-0744-1","article-title":"M2 macrophage-mediated interleukin-4 signalling induces myofibroblast phenotype during the progression of benign prostatic hyperplasia.","volume":"9","author":"J Sheng","year":"2018","journal-title":"Cell Death Dis."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"1001-1008","DOI":"10.1067\/mai.2001.114702","article-title":"IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase\u2013dependent pathway.","volume":"107","author":"S Hashimoto","year":"2001","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"153-160","DOI":"10.1006\/clim.1999.4736","article-title":"Role of Cytokines in the Pathogenesis of Anemia of Chronic Disease in Rheumatoid Arthritis.","volume":"92","author":"P Voulgari","year":"1999","journal-title":"Clin. Immunol."},{"key":"ref70","doi-asserted-by":"crossref","first-page":"144-152","DOI":"10.1016\/j.it.2011.10.004","article-title":"TNF superfamily in inflammatory disease: translating basic insights.","volume":"33","author":"M Croft","year":"2012","journal-title":"Trends Immunol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1219907","DOI":"10.3389\/fimmu.2023.1219907","article-title":"TNF superfamily control of tissue remodeling and fibrosis.","volume":"14","author":"H Steele","year":"2023","journal-title":"Front. Immunol."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"733-738","DOI":"10.1136\/thx.2009.113456","article-title":"NOX4\/NADPH oxidase expression is increased in pulmonary fibroblasts from patients with idiopathic pulmonary fibrosis and mediates TGF\u03b21-induced fibroblast differentiation into myofibroblasts.","volume":"65","author":"N Amara","year":"2010","journal-title":"Thorax."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"873-881","DOI":"10.1083\/jcb.142.3.873","article-title":"The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-\u03b21.","volume":"142","author":"G Serini","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"3955-3960","DOI":"10.1167\/iovs.07-1610","article-title":"Lovastatin inhibits TGF-beta-induced myofibroblast transdifferentiation in human tenon fibroblasts.","volume":"49","author":"T Meyer-Ter-Vehn","year":"2008","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"113301","DOI":"10.1016\/j.yexcr.2022.113301","article-title":"Macrophages alter inflammatory and fibrotic gene expression in human vocal fold fibroblasts.","volume":"419","author":"R Nakamura","year":"2022","journal-title":"Exp. Cell Res."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"4086","DOI":"10.3390\/ijms23084086","article-title":"Asthmatic Eosinophils Alter the Gene Expression of Extracellular Matrix Proteins in Airway Smooth Muscle Cells and Pulmonary Fibroblasts.","volume":"23","author":"I Janulaityte","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"ref77","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.3389\/fimmu.2018.02163","article-title":"Role of Matrix Metalloproteinase-2 in Eosinophil-Mediated Airway Remodeling.","volume":"9","author":"Y Kuwabara","year":"2018","journal-title":"Front. Immunol."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"282-290","DOI":"10.1016\/j.yexcr.2016.10.022","article-title":"PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice.","volume":"349","author":"R Gallini","year":"2016","journal-title":"Exp. Cell Res."},{"key":"ref79","doi-asserted-by":"crossref","first-page":"e15-e26","DOI":"10.1161\/CIRCRESAHA.110.235531","article-title":"Epicardial-Derived Cell Epithelial-to-Mesenchymal Transition and Fate Specification Require PDGF Receptor Signaling.","volume":"108","author":"C Smith","year":"2011","journal-title":"Circ. Res."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-120\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-120\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-120\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T11:25:32Z","timestamp":1720697132000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-120\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,21]]},"references-count":79,"URL":"https:\/\/doi.org\/10.12688\/f1000research.143514.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.143514.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.166451.r280957","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.166451.r280956","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.166451.r280956","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.166451.r280957","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,21]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-120\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.166451.r280956, Natalia Pikor, Institute of Immunobiology, Kantonsspital Sankt Gallen (Ringgold ID: 30883), St. Gallen, St. Gallen, 12 Jun 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-120\/v2#referee-response-280956","order":0,"name":"referee-response-280956","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.166451.r280957, Michelle D Tallquist, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, 09 Jul 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-120\/v2#referee-response-280957","order":1,"name":"referee-response-280957","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was funded by the Canadian Institutes of Health Research (471606)","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}