{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T04:00:40Z","timestamp":1774497640775,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.143517.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000}},{"DOI":"10.12688\/f1000research.143517.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000}}],"reference-count":150,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. High dietary intake of lutein is beneficial against eye disease, improves cardiometabolic health, protects from neurodegenerative diseases, and is beneficial for liver, kidney, and respiratory health. Lutein protects against oxidative and nitrosative stress, both of which play a major role in long COVID and mRNA vaccination injury syndromes. Lutein is an important natural agent for therapeutic use against oxidative and nitrosative stress in chronic illnesses such as cardiovascular and neurodegenerative diseases and cancer. It can also potentially inhibit spike protein-induced inflammation. Rich dietary supplementation of lutein, naturally derived in non-biodegradable Extra Virgin Olive Oil (EVOO), can most optimally be used against oxidative and nitrosative stress during post-COVID and mRNA vaccination injury syndromes. Due to its high oleic acid (OA) content, EVOO supports optimal absorption of dietary lutein. The main molecular pathways by which the SARS-CoV-2 spike protein induces pathology, nuclear factor kappa-light-chain-enhancer activated B cells (NF-\u03baB) and activated protein (AP)-1, can be suppressed by lutein. Synergy with other natural compounds for spike protein detoxification is likely.<\/ns3:p>","DOI":"10.12688\/f1000research.143517.3","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T12:20:16Z","timestamp":1729167616000},"page":"191","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical rationale for dietary lutein supplementation in long COVID and mRNA vaccine injury syndromes"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0749-0060","authenticated-orcid":false,"given":"Anthony M","family":"Kyriakopoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Nigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8191-1049","authenticated-orcid":false,"given":"Stephanie","family":"Seneff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"112328","DOI":"10.1016\/j.fct.2021.112328","article-title":"Potential health benefits of carotenoid lutein: An updated review.","volume":"154","author":"S Mitra","year":"2021","journal-title":"Food Chem. 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Thank you for your efforts to improve this paper.","URL":"https:\/\/f1000research.com\/articles\/13-191\/v3#referee-comment-12374","order":1,"name":"referee-comment-12374","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.173439.r332741, Andre Marolop Pangihutan Siahaan, Universitas Sumatera Utara, North Sumatera, 08 Nov 2024, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-191\/v3#referee-response-332741","order":2,"name":"referee-response-332741","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Stephanie Seneff<\/b>; \n<i>Posted: 09 Nov 2024<\/i>; Thank you very much!","URL":"https:\/\/f1000research.com\/articles\/13-191\/v3#referee-comment-12796","order":3,"name":"referee-comment-12796","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}