{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:32Z","timestamp":1772168912613,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.143708.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000}},{"DOI":"10.12688\/f1000research.143708.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000}},{"DOI":"10.12688\/f1000research.143708.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000}}],"reference-count":48,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:00:00Z","timestamp":1735862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Postgraduate School of Universitas Brawijaya","award":["No: 1549\/UN10.F40\/PT\/2023."],"award-info":[{"award-number":["No: 1549\/UN10.F40\/PT\/2023."]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Background\n                    <ns4:italic>Sonneratia caseolaris<\/ns4:italic>\n                    , has been widely utilized by the Indonesian.\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaves contain various active compounds, contributing to their popularity in the treatment of various diseases. Mangrove leaves are also known to exhibit very high antioxidant activity. This study aims to assess the antioxidant activity of\n                    <ns4:italic>S<\/ns4:italic>\n                    <ns4:italic>. caseolaris<\/ns4:italic>\n                    leaves extracted using different solvents. The resulting extract was evaluated for antioxidant activity by the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH) techniques. Methods Analysis of total flavonoids, total phenols, identification of active compounds with Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS), and bioinformatics were also carried out to obtain temporary conclusions about the antioxidant activity of\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaf extract. Results The results indicated that\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaves extracted with methanol and distilled water exhibited the highest antioxidant activity compared to other extracts. The analysis of total flavonoids and total phenols yielded results consistent with the antioxidant activity tests. LC-HRMS results identified three compounds in all\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaf extracts with antioxidant activity, namely TEMPO, Choline, and Betaine. TEMPO demonstrated a higher antioxidant activity than Choline and Betaine, as indicated by the binding affinity values in the bioinformatics analysis. Conclusions It is evident that\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaf extracts has the potential to serve as an effective antioxidant agent. Further research is needed to confirm how the potential compounds in\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    leaf water extracts interact with the target protein Keap1. This research aims to utilize\n                    <ns4:italic>S. caseolaris<\/ns4:italic>\n                    as active components in food products, thereby enhancing antioxidant consumption among consumers.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.143708.4","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T06:00:10Z","timestamp":1735884010000},"page":"249","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The potential of\u00a0Sonneratia caseolaris\u00a0mangrove leaves extract as a bioactive food ingredient using various water extract"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5124-1512","authenticated-orcid":false,"given":"Hartati","family":"Kartikaningsih","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nur","family":"Fitriana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ike Listya","family":"Anggraeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bambang","family":"Semedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-6401","authenticated-orcid":false,"given":"Maharani","family":"Pertiwi Koentjoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"590","DOI":"10.3390\/ijerph18020590","article-title":"Community-based portable reefs to promote mangrove vegetation growth: bridging between ecological and engineering principles.","volume":"18","author":"S Sindhu","year":"2021","journal-title":"Int. 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The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}