{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:21Z","timestamp":1772168841592,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.144117.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000}},{"DOI":"10.12688\/f1000research.144117.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000}}],"reference-count":8,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T00:00:00Z","timestamp":1721692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Hyperintensities on T2-weighted images in the spinal cord are a complex and diagnostically challenging entity that can present with diverse clinical features. This study protocol outlines a comprehensive investigation to understand the causes, clinical and imaging characteristics, and correlation with pathological findings of hyperintensities on T2-weighted images in the spinal cord. By establishing a systematic assessment approach, this study seeks to provide valuable insights into these abnormalities\u2019 diagnostic and prognostic implications. Methods The study will be conducted as a prospective observational design. Patients with clinically diagnosed or suspected spinal cord lesion presenting with intramedullary T2-weighted hyperintensity and referred for MRI evaluation will be included. Data collection will encompass patient demographics, clinical features, and extensive imaging parameters. Pathological data, when available, will be correlated with imaging findings. Various statistical methods will be employed to analyse the data, including frequency analysis, comparative tests, logistic regression, and survival analysis. Expected Results The study anticipates elucidating the spectrum of etiologies underlying hyperintensities on T2-weighted images in the spinal cord and their clinical and imaging profiles. The systematic approach will offer a structured diagnostic method, while correlations with pathological data will provide an enhanced understanding of these conditions. The results are expected to provide clinicians with valuable insights into diagnosing, treating, and prognosticating patients with spinal cord hyperintensities on T2-weighted images.<\/ns3:p>","DOI":"10.12688\/f1000research.144117.3","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T12:30:23Z","timestamp":1721737823000},"page":"502","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Role of Magnetic Resonance Imaging in evaluating T2-weighted hyperintensities in spinal cord in a tertiary care hospital in central India"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2582-8791","authenticated-orcid":false,"given":"Rishabh","family":"Dhabalia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-4593","authenticated-orcid":false,"given":"Shivali","family":"Kashikar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1824-1839","DOI":"10.1148\/rg.2019190021","article-title":"Diagnostic Approach to Intrinsic Abnormality of Spinal Cord Signal Intensity.","volume":"39","author":"M Lee","year":"2019","journal-title":"RadioGraphics."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"127-132","DOI":"10.4314\/gmj.v52i3.4","article-title":"MRI features in the non-traumatic spinal cord injury patients presenting at the Korle Bu Teaching Hospital, Accra.","volume":"52","author":"H Gbadamosi","year":"2018","journal-title":"Ghana Med. 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Disord."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1058-1073","DOI":"10.1212\/01.CON.0000433283.00221.37","article-title":"Current and New Directions in MRI in Multiple Sclerosis.","volume":"19","author":"E Klawiter","year":"2013","journal-title":"Contin. Lifelong Learn. Neurol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"469-488","DOI":"10.1053\/j.sult.2023.03.017","article-title":"The Role of MRI in Differentiating Demyelinating and Inflammatory (not Infectious) Myelopathies.","volume":"44","author":"J Tamanini","year":"2023","journal-title":"Semin. Ultrasound CT MR."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.17226\/21794","author":"E Balogh","year":"2015","journal-title":"Technology and Tools in the Diagnostic Process. In: Improving Diagnosis in Health Care."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-502\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-502\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-502\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T23:35:10Z","timestamp":1739921710000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-502\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,23]]},"references-count":8,"URL":"https:\/\/doi.org\/10.12688\/f1000research.144117.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.144117.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.144117.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.169442.r364472","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.169442.r364472","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,23]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-502\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.168113.r294013, Fabiano Reis, University of Campinas (UNICAMP), Campinas, 08 Jul 2024, version 2, 1 approved","URL":"https:\/\/f1000research.com\/articles\/13-502\/v2#referee-response-294013","order":0,"name":"referee-response-294013","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Rishabh Dhabalia<\/b>; \n<i>Posted: 19 Jul 2024<\/i>; Thank you sir for your expert review. We'll rectify the mistake.","URL":"https:\/\/f1000research.com\/articles\/13-502\/v3#referee-comment-12047","order":1,"name":"referee-comment-12047","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.169442.r364472, Dario Pfyffer, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, 19 Feb 2025, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-502\/v3#referee-response-364472","order":2,"name":"referee-response-364472","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}