{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:08Z","timestamp":1772168828308,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.144376.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000}}],"reference-count":51,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004343","name":"3M","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004343","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Background Per- and polyfluoroalkyl substances (PFAS) were used or are being used in the manufacturing of products, including consumer-use products. The resulting environmental contamination has led to widespread human exposure. This review aimed to scope the characteristics of evidence covered and applied methodology of evidence to understand -- regardless of any results on the association of gestational diabetes mellitus (GDM) and PFAS -- if a new systematic review would be justified. Methods We systematically identified reports investigating associations of PFAS with GDM following a pre-specified and pre-registered PECO framework and protocol. Results The previous systematic reviews included 8-11 reports and either conducted meta-analyses stratified by comparator, analyzed results based on only high and low exposure categories, or pooled results across comparators. Included 20 reports presented data on 24 PFAS with PFOA, PFOS, PFHxS, PFNA, and PFDA being examined in almost all. The comparators employed were heterogeneous across the reports. Conclusions Because data from at least one new report on GDM is available since the previous systematic reviews and heterogeneous comparators, an updated systematic review using SWiM could add value to the literature.<\/ns4:p>","DOI":"10.12688\/f1000research.144376.2","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:20:07Z","timestamp":1728472807000},"page":"1595","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gestational diabetes mellitus in relation to serum per- and polyfluoroalkyl substances: A scoping review to evaluate the need for a new systematic review"],"prefix":"10.12688","volume":"12","author":[{"given":"Ghazaleh","family":"Aali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4353-5422","authenticated-orcid":false,"given":"Anna K.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P.","family":"Longnecker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9687-8560","authenticated-orcid":false,"given":"Farhad","family":"Shokraneh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"513-541","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins.","volume":"7","author":"R Buck","year":"2011","journal-title":"Integr. 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This scoping review examined the studies that assess the \u2018Association\u2019 from the observational studies. Considering that confounding factors such as obesity\u2014as mentioned in the introduction\u2014can contribute to GDM, we are unable to discuss \u2018Causation\u2019 and have yet to see research suggesting such a&nbsp;mechanism.  \n<b>Comment<\/b>: What is the rationale behind excluding review articles on this topic, but included meta-analyses. Apart from these, I have no other concerns. \n<b>Response<\/b>: We excluded the narrative review articles with no usable data or a list of included studies. We, however, studied the systematic reviews and meta-analyses to identify more relevant studies for a possible systematic review in the future, avoid duplicate work, and discuss the suitability of conducting meta-analysis in these reviews.","URL":"https:\/\/f1000research.com\/articles\/12-1595\/v2#referee-comment-12551","order":2,"name":"referee-comment-12551","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Financial support for the project was from 3M (to Ramboll U.S. Consulting), and 3M suggested the broad review question. Ramboll U.S. Consulting commissioned Systematic Review Consultants LTD to conduct this scoping review in collaboration with Ramboll scientists. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}