{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:44:47Z","timestamp":1740167087931,"version":"3.37.3"},"reference-count":35,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH R01","award":["DK11035"],"award-info":[{"award-number":["DK11035"]}]},{"name":"VA Merit Award","award":["5I01BX002192"],"award-info":[{"award-number":["5I01BX002192"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Cholestatic liver disease encompasses a detrimental group of diseases that are non-discriminatory in nature. These diseases occur over every age range from infancy (biliary atresia) to geriatrics (hepatitis). They also cover both genders in the form of primary sclerosing cholangitis in men and primary biliary cholangitis in women. Oftentimes, owing to the disease progression and extensive scarring, the treatment of last resort becomes a liver transplant. In this review, we will briefly discuss and explore new avenues of understanding in the progression of cholestatic liver disease and possible therapeutic targets for intervention. The greater our understanding into the idiopathic nature of cholestatic liver disease, the better our chances of discovering treatment options to halt or reverse the progression, reducing or eliminating the need for expensive and risky transplants.<\/ns4:p>","DOI":"10.12688\/f1000research.14578.1","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T05:40:06Z","timestamp":1533015606000},"page":"1165","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Recent advances in understanding bile duct remodeling and fibrosis"],"prefix":"10.12688","volume":"7","author":[{"given":"Marinda","family":"Scrushy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-8563","authenticated-orcid":false,"given":"April","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannon","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"687-98","DOI":"10.5009\/gnl16033","article-title":"Biology of Cholangiocytes: From Bench to Bedside.","volume":"10","author":"K Yoo","year":"2016","journal-title":"Gut Liver."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"2056-66","DOI":"10.1002\/hep.27685","article-title":"Adaptive remodeling of the biliary architecture 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.15865.r36391, Tohru Itoh, Laboratory of Stem Cell Therapy, Institute for Quantitative Biosciences, The University of Tokyo, Tokyo, Japan, 31 Jul 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1165\/v1#referee-response-36391","order":0,"name":"referee-response-36391","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.15865.r36390, Leo van Grunsven, Liver Cell Biology Laboratory, Vrije Universiteit Brussel, Brussels, Belgium, 31 Jul 2018, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1165\/v1#referee-response-36390","order":1,"name":"referee-response-36390","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This material is the result of work supported by resources at the Central Texas Veterans Health Care System. Portions of this work was supported by a VA Merit Award (5I01BX002192) and National Institutes of Health R01 Grant (DK110035) to Dr. Glaser. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}