{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:38Z","timestamp":1772168858827,"version":"3.50.1"},"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Abstract: Hunter syndrome (MPS II), an X-linked recessive lysosomal storage disorder, is a result of deficiency of the iduronate 2-sulfatase enzyme (IDS), leading to cognitive impairment, systemic organ involvement, and increased dental problems. This case report describes the management of a child with Hunter syndrome who was referred to the Department of Paediatric and Preventive Dentistry for pain in the upper front teeth. Intraoral examination revealed severe early childhood caries, prompting planning for full-mouth rehabilitation under general anaesthesia due to the child\u2019s uncooperative behaviour. In response to recommendations from the Department of Otolaryngology and the Department of Paediatric Surgery, a comprehensive treatment plan consolidated full-mouth rehabilitation in addition to adenoidectomy and inguinal and umbilical herniotomy procedures during a single session of general anaesthesia. Successful interventions were reflected in the uneventful one-month follow-up of the patient, highlighting the efficacy of the interdisciplinary approach. The key takeaway underscores the importance of collaborative interventions, emphasising singular intubation for patients requiring recurrent hospitalisations, providing both monetary relief and reducing post operative healing time. Designed to address global developmental delay in the child, a personalised home care plan was also implemented. Evaluation of plaque and gingival indices before and after the home care regimen demonstrated a notable improvement, indicating an enhanced oral quality of life.<\/ns3:p>","DOI":"10.12688\/f1000research.146468.1","type":"journal-article","created":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T05:35:06Z","timestamp":1713159306000},"page":"268","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Holistic dental care for a child with Hunter syndrome: Addressing dental ramifications, overcoming challenges, and enhancing quality of life"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-5977","authenticated-orcid":false,"given":"Swagata","family":"Saha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8939-2329","authenticated-orcid":false,"given":"Krishna","family":"Priya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manju","family":"R","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krithika","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitha","family":"M Hegde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananya","family":"Rao K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhvani","family":"Abhijit Tanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2531-0051","authenticated-orcid":false,"given":"Mohanaram","family":"S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreya","family":"S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,4,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"631-639","DOI":"10.1007\/s00431-012-1703-y","article-title":"Diagnosing Hunter syndrome in pediatric practice: practical considerations and common pitfalls.","volume":"171","author":"B Burton","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"ref2","first-page":"98-100","article-title":"Hunter\u2019s syndrome and oral manifestations: a review.","volume":"17","author":"A Downs","year":"1995","journal-title":"Pediatr. Dent."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e377-e386","DOI":"10.1542\/peds.2007-1350","article-title":"Recognition and Diagnosis of Mucopolysaccharidosis II (Hunter Syndrome).","volume":"121","author":"R Martin","year":"2008","journal-title":"Pediatrics."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100549","DOI":"10.1016\/j.ymgmr.2019.100549","article-title":"The nature and impact of neurobehavioral symptoms in neuronopathic Hunter syndrome.","volume":"22","author":"J Eisengart","year":"2020","journal-title":"Mol. Genet. Metab. Rep."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e95-e101","DOI":"10.1016\/j.pedn.2019.02.001","article-title":"The Effect of Oral Care with Chlorhexidine, Vitamin E and Honey on Mucositis in Pediatric Intensive Care Patients: A Randomized Controlled Trial.","volume":"45","author":"D Konuk Sener","year":"2019","journal-title":"J. Pediatr. Nurs."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"102512","DOI":"10.1016\/j.ctim.2020.102512","article-title":"Sugar consumption, sugar sweetened beverages and Attention Deficit Hyperactivity Disorder: A systematic review and meta-analysis.","volume":"53","author":"A Farsad-Naeimi","year":"2020","journal-title":"Complement. Ther. Med."},{"key":"ref7","first-page":"109-116","article-title":"Oral health behaviours and cariogenic food consumption in children with attention-deficit\/hyperactivity disorder: a cross-sectional study.","volume":"57","author":"M Vossoughi","year":"2023","journal-title":"Can. J. Dent. Hyg."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"348-355","DOI":"10.1055\/s-0039-1697851","article-title":"Probiotics and Oral Health.","volume":"4","author":"A Haukioja","year":"2010","journal-title":"Eur. J. Dent."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1173660","DOI":"10.3389\/fnut.2023.1173660","article-title":"The role of probiotics and prebiotics in modulating of the gut-brain axis.","volume":"10","author":"F Ansari","year":"2023","journal-title":"Front. Nutr."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"302-308","DOI":"10.1016\/j.jds.2019.01.015","article-title":"Daily life habits associated with eveningness lead to a higher prevalence of dental caries in children.","volume":"14","author":"S Nishide","year":"2019","journal-title":"J. Dent. Sci."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1616-1622","DOI":"10.1017\/S0007114516000635","article-title":"The timing of the evening meal: how is this associated with weight status in UK children?","volume":"115","author":"J Coulthard","year":"2016","journal-title":"Br. J. Nutr."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1187-1201","DOI":"10.1038\/gim.2017.30","article-title":"Treatment of mucopolysaccharidosis type II (Hunter syndrome): results from a systematic evidence review.","volume":"19","author":"L Bradley","year":"2017","journal-title":"Genet. Med."},{"key":"ref13","article-title":"Complications of endotracheal intubation and other airway management procedures.","author":"J Divatia","year":"2005"},{"key":"ref14","article-title":"Literature Review Hunter\u2019s syndrome and oral manifestations: a review.","author":"A Downs"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"878-882","DOI":"10.1016\/j.ijom.2010.04.048","article-title":"Dentigerous cyst: a retrospective clinicopathological analysis of 2082 dentigerous cysts in British Columbia, Canada.","volume":"39","author":"L Zhang","year":"2010","journal-title":"Int. J. Oral Maxillofac. 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