{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:26:11Z","timestamp":1783052771800,"version":"3.54.6"},"reference-count":26,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lasers in Dentistry Research Groups, Khon Kaen University"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Background Managing recalcitrant oral lichen planus (OLP) can be challenging. Laser therapy has been suggested as an alternative to corticosteroids for treatment. Photodynamic therapy (PDT) is a non-invasive technique that enables the removal of lesions without surgery. Photobiomodulation therapy (PBMT) can promote healing and recovery of the lesions. Case presentation The objective was to treat unresponsive bilateral OLP of the whole buccal mucosae with a combination of PDT and PBMT. Results A 43-year-old Thai male presented with the severe painful reticular type of OLP of bilateral buccal mucosae involving upper and lower vestibular areas. The lesions were not remitted with either prednisolone systemic steroids or fluocinolone topical corticosteroids. After undergoing ten sessions of PDT with 10% 5-Aminolevulinic acid (5-ALA) in the form of thermoplastic gel and a 635 nm diode laser at 100 to 400 mW with an energy density of 20 to 30 J\/cm2 in continuous wave mode, combined with five interim-sessions of PBMT using a 635 nm diode laser at 200 to 300 mW with an energy density of 6 to 10 J\/cm2 in continuous wave, the patient reported relief of burning sensation beside remission of lesions without any complications. Conclusion The wide-spreading recalcitrant OLP with burning sensation can be managed by combining PDT and PBMT.<\/ns4:p>","DOI":"10.12688\/f1000research.146733.1","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T06:20:06Z","timestamp":1709274006000},"page":"152","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Recalcitrant oral lichen planus involving bilaterally buccal mucosae treated with a combination of photodynamic and photobiomodulation therapies"],"prefix":"10.12688","volume":"13","author":[{"given":"Juthamast","family":"Trakarnboonkij","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7801-6123","authenticated-orcid":false,"given":"Suwat","family":"Tanya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilairat","family":"Sarideechaigul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajiravudh","family":"Subarnbhesaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peera","family":"Tabbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-9381","authenticated-orcid":false,"given":"Sajee","family":"Sattayut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"539-551","DOI":"10.1007\/s00403-016-1667-2","article-title":"Oral lichen planus: a literature review and update.","volume":"308","author":"M Alrashdan","year":"2016","journal-title":"Arch. 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We are incorporating the suggestion of modification and will provide an updated version shortly.","URL":"https:\/\/f1000research.com\/articles\/13-152\/v1#referee-comment-11763","order":1,"name":"referee-comment-11763","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.160849.r275899, Alberto Rodriguez-Archilla, Universidad de Granada, Granada, 08 Jun 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-152\/v1#referee-response-275899","order":2,"name":"referee-response-275899","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sajee Sattayut<\/b>; \n<i>Posted: 13 Jun 2024<\/i>; We greatly appreciate the reviewer for bringing important issues to our attention in the case report. We are aware of the limitations of the case report and planning further studies. We will also consider your kind suggestion regarding the keywords.","URL":"https:\/\/f1000research.com\/articles\/13-152\/v1#referee-comment-11764","order":3,"name":"referee-comment-11764","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This work was supported by Lasers in Dentistry Research Groups, Khon Kaen University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}