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Organ engineering offers hope through stem cell-based organ generation. However, the crucial sterilization step in scaffold preparation poses challenges. This study conducted a systematic review of studies that analysed the extracellular matrix (ECM) conditions of decellularised lungs subjected to different sterilisation processes. A search was performed for articles published in the PubMed, Web of Sciences, Scopus, and SciELO databases according to the PRISMA guidelines. Overall, five articles that presented positive results regarding the effectiveness of the sterilisation process were selected, some of which identified functional damage in the ECM. Was possible concluded that regardless of the type of agent used, physical or chemical, all of them demonstrated that sterilisation somehow harms the ECM. An ideal protocol has not been found to be fully effective in the sterilisation of pulmonary scaffolds for use in tissue and\/or organ engineering.<\/ns3:p>","DOI":"10.12688\/f1000research.147670.1","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T09:50:05Z","timestamp":1717062605000},"page":"554","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Extracellular matrix of lung scaffolds submitted to different means of sterilization: a systematic review"],"prefix":"10.12688","volume":"13","author":[{"given":"Ricardo S.","family":"Moura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joao Pedro R.","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano L.","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa D.","family":"Cereta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego A. 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Jo\u00e3o Pedro R. Afonso receives a PhD scholarship from the Goi\u00e1s State Research Support Foundation (FAPEG), process number: 2023\/10267000720. RPV receive grants Research Productivity, modality PQII of the National Council for Scientific and Technological Development (local acronym CNPq), Brazil. LVFO receive grants Research Productivity, modality PQII; Process no. 310241\/2022-7 of the National Council for Scientific and Technological Development (local acronym CNPq), Brazil. These grants do not influence any of the stages of the study, from the conception, development, analysis, and interpretation of the results. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}