{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:50:58Z","timestamp":1787021458413,"version":"build-2736575974"},"reference-count":97,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010757","name":"National Centre for the Replacement Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["NC\/X001172\/1"],"award-info":[{"award-number":["NC\/X001172\/1"]}],"id":[{"id":"10.13039\/501100010757","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    On the 26th January 2023, a free to attend, \u2018improving\n                    <ns3:italic>in vivo<\/ns3:italic>\n                    snake venom research: a community discussion\u2019 meeting was held virtually. This webinar brought together researchers from around the world to discuss current neutralisation of venom lethality mouse assays that are used globally to assess the efficacy of therapies for snakebite envenoming. The assay\u2019s strengths and weaknesses were highlighted, and we discussed what improvements could be made to refine and reduce animal testing, whilst supporting preclinical antivenom and drug discovery for snakebite envenoming. This report summarises the issues highlighted, the discussions held, with additional commentary on key perspectives provided by the authors.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.148223.1","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T11:20:05Z","timestamp":1710501605000},"page":"192","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Improving\u00a0in vivo\u00a0assays in snake venom and antivenom research: A community discussion"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-9539","authenticated-orcid":false,"given":"Amy E","family":"Marriott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas R","family":"Casewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Lilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Mar\u00eda","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-6482","authenticated-orcid":false,"given":"Stuart","family":"Ainsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"17079","DOI":"10.1038\/nrdp.2017.79","article-title":"Snakebite envenoming.","volume":"3","author":"J Gutierrez","year":"2017","journal-title":"Nat. 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