{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:36:31Z","timestamp":1789810591843,"version":"4.0.1"},"reference-count":110,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI103280"],"award-info":[{"award-number":["R01AI103280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI123808-01"],"award-info":[{"award-number":["R21AI123808-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32AI007172-37"],"award-info":[{"award-number":["T32AI007172-37"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"St. Louis Children's Hospital"},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Children's Discovery Institute of Washington University"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    Malaria remains a significant contributor to global human mortality, and roughly half the world\u2019s population is at risk for infection with\n                    <ns4:italic>Plasmodium<\/ns4:italic>\n                    spp. parasites. Aggressive control measures have reduced the global prevalence of malaria significantly over the past decade. However, resistance to available antimalarials continues to spread, including resistance to the widely used artemisinin-based combination therapies. Novel antimalarial compounds and therapeutic targets are greatly needed. This review will briefly discuss several promising current antimalarial development projects, including artefenomel, ferroquine, cipargamin, SJ733, KAF156, MMV048, and tafenoquine. In addition, we describe recent large-scale genetic and resistance screens that have been instrumental in target discovery. Finally, we highlight new antimalarial targets, which include essential transporters and proteases. These emerging antimalarial compounds and therapeutic targets have the potential to overcome multi-drug resistance in ongoing efforts toward malaria elimination.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.14874.1","type":"journal-article","created":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T10:45:22Z","timestamp":1533120322000},"page":"1170","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Tackling resistance: emerging antimalarials and new parasite targets in the era of elimination"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7723-4428","authenticated-orcid":false,"given":"Emily S.","family":"Mathews","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey R.","family":"Odom John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2018,8,1]]},"reference":[{"key":"ref-1","first-page":"158-164","article-title":"Un nouveau parasite trouv\u00e9 dans le sang de malades atteints de fi\u00e8vre palustre. 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National Institutes of Health (R01AI103280 and R21AI123808-01 to Audrey Odom John and T32AI007172-37 to Emily Mathews), the Children\u2019s Discovery Institute of Washington University and St. Louis Children\u2019s Hospital (Audrey Odom John), and the Burroughs Wellcome Fund (to Audrey Odom John). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}