{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:38Z","timestamp":1772168918659,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.149757.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000}}],"reference-count":39,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Anxiety has been reported to be one of the most common epidemics in recent years. The present study focused on understanding the association between early menarche and the prevalence of anxiety and anxiety symptoms among adult undergraduate students. Methods This was an observational, case-control study. The sample included 146 young female adults aged more than or equal to 18 years pursuing the Bachelor of Medicine and Bachelor of Surgery (MBBS) and Bachelor of Dental Sciences (BDS). Using an online questionnaire, participants were asked to recall and enter the age at which they attained menarche. We used the Generalized Anxiety Disorder 7- Item Questionnaire (GAD-7) to measure the severity of their present anxiety symptoms. Results The results showed a significant increase in anxiety symptoms in participants who had early menarche compared to those who did not have early menarche. The mean score on the GAD-7 Questionnaire for the cases was 9.93 and the control group was 6.89. The GAD-7 scores among the cases group were significantly higher in the GAD-7 scores than in the control group. Conclusions This study concluded that early menarche is associated with higher anxiety levels in young adults.<\/ns3:p>","DOI":"10.12688\/f1000research.149757.2","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T10:40:15Z","timestamp":1723200015000},"page":"807","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A study of association between early menarche and anxiety in undergraduate\u00a0 students"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0888-1614","authenticated-orcid":false,"given":"Poorva","family":"Bakshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9827-7443","authenticated-orcid":false,"given":"Sharanya B.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abira","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-2916","authenticated-orcid":false,"given":"Vasudha","family":"K G","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-9685","authenticated-orcid":false,"given":"Keshava","family":"Pai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9565-3631","authenticated-orcid":false,"given":"Radhika","family":"K","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2858-0911","authenticated-orcid":false,"given":"Priyanka Renita","family":"D'Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshma","family":"N S","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"ref2","article-title":"Sustainable Development Goals."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e111027","DOI":"10.1371\/journal.pone.0111027","article-title":"Secular trends in menarcheal age in India-evidence from the Indian Human Development Survey.","volume":"9","author":"P Pathak","year":"2014","journal-title":"PLoS One."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"26-27","DOI":"10.3345\/cep.2020.00521","article-title":"Why should we be concerned about early menarche?","volume":"64","author":"H Lee","year":"2021","journal-title":"Clin. 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(Version 1.x) [Computer Software]."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-807\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-807\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-807\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T02:30:12Z","timestamp":1746239412000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-807\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":39,"URL":"https:\/\/doi.org\/10.12688\/f1000research.149757.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.149757.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.170051.r312738","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.170051.r312738","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-807\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.170051.r312738, Gayatri Bhatia, All India Institute of Medical Sciences, Rajkot, 20 Aug 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-807\/v2#referee-response-312738","order":0,"name":"referee-response-312738","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.164254.r304526, Sanjeev Badiger, A J Institute of Medical Sciences and Research Centre, Mangaluru, 30 Jul 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-807\/v1#referee-response-304526","order":1,"name":"referee-response-304526","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Sharanya Shetty<\/b>; \n<i>Posted: 05 Aug 2024<\/i>; Dear Sir, Thank you very much for your review of our article. We are pleased to hear that you found our study to be novel. We appreciate your insightful comments and suggestions.  Regarding your suggestion for considering factors like socioeconomic conditions and environmental factors for avoiding the bias, we acknowledge the importance of considering these factors and its impact on menarche and anxiety. Though we have mentioned about this in the limitations, we have made an attempt to discuss regarding social, cultural factors, guidance, communication factors in the discussion in addition to the limitations in the revised manuscript. In future research we plan to explore the influence of these variables to provide a more comprehensive understanding.  We appreciate your positive feedback on results and discussion part and the limitations. Once again thank you for your valuable feedback and recognition of our contribution to understanding the association between early menarche and anxiety in undergraduate students. We will consider your suggestions for future research directions.  Regards, Dr. Sharanya B. Shetty Department of Psychiatry, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India","URL":"https:\/\/f1000research.com\/articles\/13-807\/v2#referee-comment-12163","order":2,"name":"referee-comment-12163","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}