{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:45Z","timestamp":1772168925827,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.15170.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000}},{"DOI":"10.12688\/f1000research.15170.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000}}],"reference-count":39,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:\u00a0<\/ns4:bold>\n                    Hand, foot and mouth disease (HFMD) is a common contagious disease among children under 5 years, particularly in the Asia-Pacific-region. We report a localized outbreak\u00a0of childhood HFMD for the\u00a0first time from Bangladesh, diagnosed only based on clinical features due to lack in laboratory-diagnostic facilities.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Methods:\u00a0<\/ns4:bold>\n                    Following the World Health Organization\u2019s case-definition, we conducted a rapid-appraisal of HFMD among all of the 143 children attending Pabna Medical College and General Hospital with fever, mouth ulcers and extremity rash. Data were collected between September and November 2017 using a preset syndromic approach and stringent differential diagnostic-protocols.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Results:\u00a0<\/ns4:bold>\n                    The mean age of children was 2.9\u00b12.3 years. There was a significant difference among the age and sex of children (P=0.98), first sibling being more belonging to middle-income families (62%). Younger children (&lt;5 years) were more likely to suffer with moderate-to-high (38.5\u00b0C) fever (P&lt;0.04), painful oral ulcers (P&lt;0.03) and painful\/itchy rash (P&lt;0.01). Sex did not differ with other symptoms, but boys had less painful oral ulcers than girls (P&lt;0.04). Fever (63%) and chicken-pox-like-rash (62%) was observed more in mid-October to mid-November than September to mid-October (P&lt;0.01 and P&lt;0.03, respectively). No differences in symptoms (fever, oral ulcers and extremity rash) were observed with precipitation, nor with ambient temperature. Children &lt;5 years (85%) had quicker recovery (within 5 days) than those \u22655 years (69%), (P&lt;0.04), with marginal differences in sex (P&lt;0.05).\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusions:\u00a0<\/ns4:bold>\n                    Our findings highlight potential usefulness in diagnosing HFMD based on clinical parameters, although stringent differential diagnosis remains indispensable, which is particularly applicable for resource-constrained countries lacking appropriate virology\/essential laboratories. Since no specific treatment or effective vaccination is available for HFMD, supportive therapy and preventive measures remain the primary methods to circumvent disease-transmission augmented by climate-related factors. Standardized virology laboratory warrants appropriate diagnosis and globally representative multivalent-vaccine deem essential towards preventing HFMD.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.15170.3","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T09:37:57Z","timestamp":1561714677000},"page":"1156","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Emerging Hand Foot Mouth Disease in Bangladeshi Children- First Report of Rapid Appraisal on Pocket Outbreak: Clinico-epidemiological Perspective Implicating Public Health Emergency"],"prefix":"10.12688","volume":"7","author":[{"given":"Md. Azraf","family":"Hossain Khan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3437-4014","authenticated-orcid":false,"given":"Kazi Selim","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K. M.","family":"Muraduzzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Abid","family":"Hossain Mollah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.21485.r50588, H Rogier van Doorn, Oxford University Clinical Research Unit, Hanoi, Vietnam, 26 Jul 2019, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1156\/v3#referee-response-50588","order":0,"name":"referee-response-50588","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.21485.r50587, Md. Azizul Haque, Department of Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh, 08 Jul 2019, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1156\/v3#referee-response-50587","order":1,"name":"referee-response-50587","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kazi Selim Anwar<\/b>; <i>Posted: 11 Jul 2019<\/i>; I, on behalf of all authors cordially thank reviewer-2 for reviewing our on-line published paper so brilliantly.&nbsp;&nbsp;We do extend all our best wishes for reviewing our paper with so much patience and upmost care with largely valuable comments and section\/topic specific valuable suggestions&nbsp;being seriously careful towards adding values to improve the quality of our paper.We cordially wish that any reviewer should possess such qualities, which we believe most reviewers do have those (except few).We also recommend that the F1000Research should take up this reviewer (the 2nd one) in their reviewing panel if can not be taken in the editorial board right now.We wish all the bests for our 2nd reviewer, per se.","URL":"https:\/\/f1000research.com\/articles\/7-1156\/v3#referee-comment-4745","order":2,"name":"referee-comment-4745","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero \"No rights reserved\" data waiver (CC0 1.0 Public domain dedication).","order":0,"name":"copyright-info","label":"Copyright"}]}}