{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:03:06Z","timestamp":1777755786322,"version":"3.51.4"},"update-to":[{"DOI":"10.12688\/f1000research.151907.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000}}],"reference-count":25,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Introduction Actinomycosis is an uncommon inflammatory bacterial disease caused by Actinomyces species, especially Actinomyces Israeli. Abdominopelvic forms are relatively rare and may involve the colon as a solid mass, mimicking a malignant tumor. Case presentation A 68-year-old Tunisian man, with a history of diabetes, hypertension, penicillin allergy, and renal failure, presented to the emergency department with abdominal pain, vomiting, and bowel obstruction. CT scan showed an acute intestinal obstruction upstream with obstructive tissular mass at the sigmoid colon. Emergency surgery revealed a sigmoid mass and a pre-perforative cecum. Total colectomy was performed, with ileostomy and distal end closure. Histological examination confirmed Actinomyces infection. The patient was then placed on long-term doxycycline and Bactrim, with no recurrence over a 9-month follow-up period. Conclusion Abdominal actinomycosis, though rare, presents diagnostic challenges. It can be mistaken for malignancy, leading to unnecessary surgery in non-complicated cases, since it is effectively treated by antibiotics. In complicated cases, a combined approach involving both surgery and antibiotic therapy is necessary until the infection is completely eradicated.<\/ns3:p>","DOI":"10.12688\/f1000research.151907.2","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T09:25:47Z","timestamp":1724923547000},"page":"669","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Acute large bowel obstruction with actinomycosis of the sigmoid colon mimicking neoplasm"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-2923","authenticated-orcid":false,"given":"Mohamed","family":"Hajri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rami","family":"Zouari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9269-8365","authenticated-orcid":false,"given":"Ines","family":"Mallek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-0072","authenticated-orcid":false,"given":"Dhouha","family":"Bacha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rached","family":"Bayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sana","family":"ben slama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"ref1","first-page":"183-197","article-title":"Actinomycosis: etiology, clinical features, diagnosis, treatment, and management.","volume":"7","author":"F Valour","year":"2014 Jul 5","journal-title":"Infect. Drug Resist."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"bcr-2018-227728","DOI":"10.1136\/bcr-2018-227728","article-title":"Actinomycosis of the omentum with invasion of the abdominal wall, small bowel and transverse colon mimicking malignancy.","volume":"12","author":"E Caplan","year":"2019 Jan 28","journal-title":"BMJ Case Rep."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"613-628","DOI":"10.2217\/fmb.14.130","article-title":"Actinomycosis: a frequently forgotten disease.","volume":"10","author":"L Boyanova","year":"2015","journal-title":"Future Microbiol."},{"key":"ref4","first-page":"251-258","article-title":"Abdominal Actinomycosis Mimicking Colon Cancer.","volume":"114","author":"E T\u00e2rcoveanu","year":"2019","journal-title":"Chir. Buchar. Rom."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"106794","DOI":"10.1016\/j.ijscr.2022.106794","article-title":"Actinomycosis mimicking a pancreatic head neoplasm: A case report.","volume":"91","author":"M Hajri","year":"2022 Feb 1","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s13256-021-02812-7","article-title":"Abdominal actinomycosis mimicking a transverse colon malignancy: a case report and review of the literature.","volume":"15","author":"G Pamathy","year":"2021 May 3","journal-title":"J. Med. Case Rep."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"231-234","DOI":"10.1080\/00365540500444645","article-title":"Severe large bowel obstruction secondary to infection with Actinomyces israelii.","volume":"38","author":"P Valko","year":"2006","journal-title":"Scand. J. Infect. Dis."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"735-741","DOI":"10.1016\/j.revmed.2010.06.001","article-title":"Tumoral form of abdominal actinomycosis: a retrospective case series of seven patients.","volume":"31","author":"S Ketata","year":"2010 Nov","journal-title":"Rev. Med. Interne."},{"key":"ref9","first-page":"41-44","article-title":"Clinical, endoscopic, and histopathological aspects of sigmoid actinomycosis; a case report and literature review.","volume":"7","author":"F Zamani","year":"2015 Jan","journal-title":"Middle East J. Dig. Dis."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12893-018-0386-3","article-title":"Severe abdominopelvic actinomycosis with colon perforation and hepatic involvement mimicking advanced sigmoid colon cancer with hepatic metastasis: a case study.","volume":"18","author":"S Yang","year":"2018 Aug 2","journal-title":"BMC Surg."},{"key":"ref11","first-page":"447","article-title":"Abdominopelvic Actinomycosis-The Diagnostic and Therapeutic Challenge of the Most Misdiagnosed Disease.","volume":"12","author":"A Vasilescu","year":"2022 Mar 17","journal-title":"Life Basel Switz."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1465-1468","DOI":"10.1111\/ans.16141","article-title":"Clinical aspects of abdominal actinomycosis: a systematic review.","volume":"90","author":"C Manterola","year":"2020 Jul","journal-title":"ANZ J. Surg."},{"key":"ref13","first-page":"448-451","article-title":"Colonic Actinomycosis Presenting as Diffuse Colitis and Protein-Losing Enteropathy: A Case Report.","volume":"58","author":"C Lin","year":"2003 Sep 1","journal-title":"Gastrointest. Endosc."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"107957","DOI":"10.1016\/j.ijscr.2023.107957","article-title":"Case report: Colonic actinomycosis\u2013A rare cause of a locally advanced colonic tumour.","volume":"105","author":"M Lyew","year":"2023","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref15","first-page":"102-105","article-title":"Colonic pseudotumor caused by abdominal actinomycosis: A case report.","volume":"88","author":"M Morais-Kansaon","year":"2020","journal-title":"Cir. Cir."},{"key":"ref16","first-page":"333-337","article-title":"Pseudotumoral Actinomycosis Mimicking Malignant Colic Disease: A Case Report and Literature Review.","volume":"36","author":"R Jabi","year":"2019 Oct 14","journal-title":"Visc. Med."},{"key":"ref17","first-page":"334-336","article-title":"Colonic actinomycosis: a pseudo-tumour that mimics colonic neoplasm.","volume":"25","author":"K Hui","year":"2019","journal-title":"Hong Kong Med. J."},{"key":"ref18","first-page":"240-244","article-title":"Acute abdomen with actinomycosis of the colon: a case report.","volume":"84","author":"B Garc\u00eda-Z\u00fa\u00f1iga","year":"2016","journal-title":"Cir. Cir. Engl. Ed."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"231-234","DOI":"10.1080\/00365540500444645","article-title":"Severe large bowel obstruction secondary to infection with Actinomyces israelii.","volume":"38","author":"P Valko","year":"2006 Jan 1","journal-title":"Scand. J. Infect. Dis."},{"key":"ref20","first-page":"74-75","article-title":"Colonic actinomycosis masquerading as perforated colonic carcinoma.","volume":"28","author":"S Saha","year":"2007 Apr 1","journal-title":"Trop. Gastroenterol."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"583-586","DOI":"10.3349\/ymj.2006.47.4.583","article-title":"Abdominal actinomycosis associated with a sigmoid colon perforation in a patient with a ventriculoperitoneal shunt.","volume":"47","author":"E Jung","year":"2006","journal-title":"Yonsei Med. J."},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1-5","DOI":"10.1186\/1471-230X-5-1","article-title":"A rare case of ascending colon actinomycosis mimicking cancer.","volume":"5","author":"D Filippou","year":"2005","journal-title":"BMC Gastroenterol."},{"key":"ref23","article-title":"Abdominal actinomycosis simulating malignancy of the right colon.","author":"B I\u015f\u0131k","year":"2005 cited 2024 Feb 18"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"186-189","DOI":"10.1590\/S1413-86702004000200011","article-title":"Actinomycosis simulating malignant large bowel obstruction.","volume":"8","author":"J Bittencourt","year":"2004","journal-title":"Braz. J. Infect. Dis."},{"key":"ref25","first-page":"108-109","article-title":"Actinomycosis of the Colon: A Rare Form of Presentation.","volume":"35","author":"T Ferrari","year":"2000 Jan 1","journal-title":"Scand. J. Gastroenterol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-669\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-669\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-669\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T02:06:58Z","timestamp":1726106818000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-669\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":25,"URL":"https:\/\/doi.org\/10.12688\/f1000research.151907.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.151907.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.170479.r318558","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.170479.r318558","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-669\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.170479.r318558, Mhasisielie Zumu, Dr Arun RS, Medical Gastroenterology, The Madras Medical Mission, Chennai, Tamil Nadu, 12 Sep 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-669\/v2#referee-response-318558","order":0,"name":"referee-response-318558","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.166599.r311560, Prajwal Dahal, Grande International Hospital, Tokha, Kathmandu, 21 Aug 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-669\/v1#referee-response-311560","order":1,"name":"referee-response-311560","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Mohamed Hajri<\/b>; \n<i>Posted: 29 Aug 2024<\/i>; Thank you very much for your positive feedback and constructive suggestions. I appreciate your time and effort in reviewing my manuscript.  I will include the values of vitals, blood parameters, and serum urea\/creatinine at the time of presentation in the revised version. I understand the recommendation to limit the number of references to below 10. However, many of the references have been used in the summary table to cite the different cases from the literature. Would it be feasible to keep them included?&nbsp;If you still recommend reducing the number of references, I would be willing to do so.  Thank you again for your valuable input.","URL":"https:\/\/f1000research.com\/articles\/13-669\/v2#referee-comment-12332","order":2,"name":"referee-comment-12332","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}