{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:51:11Z","timestamp":1787021471478,"version":"build-2736575974"},"update-to":[{"DOI":"10.12688\/f1000research.154750.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000}},{"DOI":"10.12688\/f1000research.154750.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000}}],"reference-count":21,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Polyetheretherketone (PEEK) is widely used in the biomedical field due to its outstanding biological and mechanical properties. Originally employed as a temporary abutment in implantology, recent research has expanded its indications for more definitive applications, such as frameworks and dental post and core. However, PEEK\u2019s inert nature and low surface energy pose challenges for adhesion, necessitating surface modifications. Various physical and chemical modification techniques, including acid etching (e.g., 98% sulfuric acid), sandblasting with alumina oxide (Al\u2082O\u2083), plasma treatment, laser irradiation, silanization, and air abrasion with silica-coated particles, have been proposed to enhance PEEK\u2019s bonding performance. Despite numerous clinical investigations, standardized protocols for surface treatment remain lacking. This systematic review aims to assess the impact of surface treatments on the bonding performance of PEEK posts. Methods A detailed search of the literature will be conducted across several databases including PubMed, Scopus and clinical trial registries. Additional databases such as Cochrane Central, EMBASE, Web of Science and EBSCO will also be included. The search strategy will target controlled randomized studies and non-randomized clinical trials evaluating the impact of surface treatments on PEEK post adhesion strength. The Newcastle-Ottawa Scale (NOS) will be used to assess bias in non-randomized studies, while the Cochrane Risk of Bias (ROB II) tool will be employed for evaluating randomized controlled trials. Data extraction will focus on study design, treatment methods, outcomes and results. This systematic review protocol will adhere to the guidelines for systematic reviews outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Discussion The discussion will explore the implications of findings on clinical practice, highlighting the importance of enhancing PEEK\u2019s bioactivity and surface energy to improve bonding efficacy in dental procedures. Moreover, it will suggest areas for future research to advance dental materials science, aiming to optimize the utilization of PEEK in dental applications Systematic review registration PROSPERO: CRD42024529783 (Registered on 08\/04\/2024).<\/ns3:p>","DOI":"10.12688\/f1000research.154750.3","type":"journal-article","created":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T22:04:13Z","timestamp":1743717853000},"page":"951","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of surface treatments on the bond strength of polyetheretherketone posts: a systematic review protocol"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7574-1872","authenticated-orcid":false,"given":"Hanen","family":"Boukhris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5080-4179","authenticated-orcid":false,"given":"Aymen","family":"Ben Hadj Khalifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayet","family":"Hajjami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-9425","authenticated-orcid":false,"given":"Souha","family":"Boudegga Ben Youssef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"S39-S42","DOI":"10.4103\/jpbs.jpbs_159_22","article-title":"Endocrowns Versus Post-core Retained Crowns as a Restoration of Root Canal Treated Molars - A Review Article.","volume":"14","author":"M Mezied","year":"2022 Jul","journal-title":"J. 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Below, we provide detailed responses to each comment and indicate the revisions made accordingly.  \n<b>1.Introduction<\/b>  \n<b>Comment:<\/b> &quot;The introduction should start with PEEK\u2019s material properties, history, and applications before discussing its role in post-and-core restorations.&quot; \n<b>Response:<\/b> We have reorganized the introduction to first present PEEK\u2019s chemical composition, mechanical properties, and biomedical applications before focusing on its role in post-and-core restorations. The revised introduction now follows a logical progression, improving the contextual framework of the study. \n<b>Comment:<\/b> &quot;Please provide more details on the different surface treatment techniques of PEEK.&quot; \n<b>Response:<\/b> We have expanded the discussion on surface treatments, including plasma treatment, acid etching (98% sulfuric acid), sandblasting (50 \u03bcm alumina oxide), laser surface modification, silanization, and air abrasion. These modifications and their rationale are now clearly described. \n<b>Comment:<\/b> &quot;There is limited discussion on the comparative performance of PEEK posts against conventional materials like metal, zirconia, and fiber posts.&quot; \n<b>Response:<\/b> The revised manuscript now includes a comparative analysis highlighting the strengths and limitations of PEEK versus conventional post materials, emphasizing its clinical relevance.    \n<b>Comment:<\/b> &quot;How will studies with unclear risk of bias be handled in the analysis?&quot; \n<b>Response:<\/b> We have specified that studies with an unclear risk of bias will undergo sensitivity analysis, and their influence on the final conclusions will be carefully considered. \n<b>Comment:<\/b> &quot;Clarify how heterogeneity among studies will be addressed in the meta-analysis.&quot; \n<b>Response:<\/b> A heterogeneity assessment will be conducted using I&sup2; statistics, and subgroup analysis or meta-regression will be applied if significant heterogeneity is detected. \n<b>Comment:<\/b> &quot;Provide more precise definitions of key outcomes.&quot; \n<b>Response:<\/b> We have revised the outcomes section to specify assessment methods for bond strength (e.g., push-out tests), fracture resistance, and marginal adaptation quality.   These responses, along with the corresponding revisions, have strengthened our manuscript and improved its clarity. Thank you for your constructive feedback.","URL":"https:\/\/f1000research.com\/articles\/13-951\/v3#referee-comment-13237","order":1,"name":"referee-comment-13237","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.177690.r366864, Noha Taymour, Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, 24 Feb 2025, version 2, 2 approved with reservations, 1 not approved","URL":"https:\/\/f1000research.com\/articles\/13-951\/v2#referee-response-366864","order":2,"name":"referee-response-366864","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Hanen Boukhris<\/b>; \n<i>Posted: 24 Mar 2025<\/i>; We sincerely appreciate the reviewers' thorough and insightful evaluation of our work. Their constructive feedback has been invaluable in refining the study and strengthening its overall quality.  In response, we have carefully addressed each concern, ensuring consistency in PROSPERO registration, refining the introduction to enhance clarity and conciseness, and reinforcing the methodology to improve robustness. We have also provided additional clarifications on inclusion criteria, search strategies, and ethical considerations, thereby enhancing transparency and reliability. Furthermore, we have incorporated the latest advancements in surface treatment techniques, ensuring that the study remains relevant to current scientific and clinical practices. Standardizing outcome metrics, particularly in bond strength measurement, further improves the study's comparability and applicability.  We believe these enhancements significantly contribute to the rigor and impact of our work. We remain open to any further recommendations and greatly value the reviewers' expertise and insights in advancing the quality of this research.","URL":"https:\/\/f1000research.com\/articles\/13-951\/v3#referee-comment-13620","order":3,"name":"referee-comment-13620","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.179536.r375420, Retno Ardhani, Universitas Gadjah Mada, Jalan, 18 Apr 2025, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-951\/v3#referee-response-375420","order":4,"name":"referee-response-375420","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}