{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:03Z","timestamp":1772168883494,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.154968.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000}},{"DOI":"10.12688\/f1000research.154968.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000}}],"reference-count":64,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Navamindradhiraj University Research Fund","award":["RESEARCH.NMU 62\/2564"],"award-info":[{"award-number":["RESEARCH.NMU 62\/2564"]}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Stroke survivors, particularly those of working age, are at an increased risk of recurrent stroke within one\u2013five years of the initial event, largely due to suboptimal management of risk factors. This study aimed to identify lifestyle and occupational factors associated with recurrent stroke in this demographic population. Methods This case-control study included 100 patients with recurrent ischemic stroke and 200 ischemic stroke survivors without recurrence, who were recruited from the hospital database. Multivariate logistic regression was used to identify significant factors associated with recurrence, which were presented as adjusted odds ratios (aORs) with 95% confidence intervals (CIs). Results The mean age was 45.4 years (SD = 15.1) among cases and 50.6 years (SD = 6.5) among controls. The male-to-female ratios were 1.17:1 and 1.94:1 in the case and control groups, respectively. Significant factors associated with recurrent stroke included female sex (aOR: 1.83; 95% CI [1.10\u20133.29]), high fasting blood sugar (aOR: 3.70; 95% CI [1.66\u20138.27]), current alcohol consumption (aOR: 3.63; 95% CI [2.01\u20136.54]), sedentary lifestyle (aOR: 2.77; 95% CI [1.50\u20135.13]), and lack of workplace support for health (aOR: 2.02; 95% CI [1.13\u20133.63]). The associations between these factors and stroke recurrence varied according to the age group. Conclusions This study highlights the critical role of modifiable lifestyle and occupational factors in stroke recurrence among working-age adults. Tailored age-specific prevention strategies\u2014emphasizing physical activity, reduced alcohol use, and improved workplace health environments\u2014may reduce the risk of recurrence and enhance health outcomes in this population.<\/ns3:p>","DOI":"10.12688\/f1000research.154968.3","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T10:45:07Z","timestamp":1749120307000},"page":"1445","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lifestyle and Occupational Factors Associated with Recurrent Stroke among Working-Age Adults in Urban Areas of Thailand"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9742-5790","authenticated-orcid":false,"given":"Yupha","family":"Wongrostrai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8147-6462","authenticated-orcid":false,"given":"Araya","family":"Chiangkhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0362-1342","authenticated-orcid":false,"given":"Charin","family":"Suwanwong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-9200","authenticated-orcid":false,"given":"Anon","family":"Khunakorncharatphong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"208-211","DOI":"10.1055\/s-0038-1649503","article-title":"Global burden of stroke.","volume":"38","author":"M Katan","year":"2018","journal-title":"Semin. 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Methods  Added explanation on how \n<b>confounding variables<\/b> were controlled: variables with p &lt; 0.2 in univariate analysis were included in the adjusted logistic regression model. Clarified that \n<b>consecutive sampling<\/b> was used for eligible participants, and \n<b>random selection<\/b> was applied only for controls. Clarified that the study did not use randomization in an interventional sense, but used appropriate random selection methods for observational controls. Provided details on the \n<b>questionnaire validation<\/b> process: literature-based design, expert review, pilot testing, and Cronbach\u2019s alpha reliability scores.  Discussion  Rewrote parts of the discussion to offer \n<b>more critical reflection<\/b> and explicitly linked the findings (gender, sedentary behavior, marital status, workplace factors) to existing literature, especially regarding age-specific patterns.  Other Sections  Confirmed that all \n<b>claims are now supported by appropriate, current references<\/b> throughout the manuscript.","URL":"https:\/\/f1000research.com\/articles\/13-1445\/v3#referee-comment-13740","order":2,"name":"referee-comment-13740","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.183217.r390104, Anthony Rudd, King\u2019s College, London, 19 Jun 2025, version 3, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1445\/v3#referee-response-390104","order":3,"name":"referee-response-390104","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"This research was financially supported by Navamindradhiraj University Research Fund-RESEARCH.NMU 62\/2564. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}