{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:48:57Z","timestamp":1775756937472,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.155205.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000}}],"reference-count":15,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Abstract Paragangliomas are rare neuroendocrine tumors, often associated with catecholamine secretion. These tumors can arise in various locations, with the majority found in the abdomen and pelvis, while a smaller percentage occurs in the thorax and head and neck regions. Diaphragmatic paragangliomas are exceedingly rare, with only two documented cases in the literature. This report details a case of a primary diaphragmatic paraganglioma in a 59-year-old patient presenting with unexplained weight loss, tremors, and diaphoresis. Imaging studies revealed a mass in the right lobe of the liver, later identified as a diaphragmatic paraganglioma during surgery. The case underscores the importance of preoperative catecholamine assessment and careful surgical planning due to the risks associated with tumor manipulation. Complete surgical resection, although challenging, remains the definitive treatment, especially in hypervascular tumors located near major vascular structures.<\/ns3:p>","DOI":"10.12688\/f1000research.155205.2","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T07:25:10Z","timestamp":1729841110000},"page":"1023","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Unveiling an anomalous diaphragmatic paraganglioma mimicking a hepatic tumor"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9265-4835","authenticated-orcid":false,"given":"Ermilo","family":"Echeverria Ortegon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Millet-Herrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Casillas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1115-1117","DOI":"10.1111\/1759-7714.13865","article-title":"Diaphragmatic paraganglioma protruding into the right thoracic cavity.","volume":"12","author":"K Minegishi","year":"2021 Apr","journal-title":"Thorac Cancer."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"159-168","DOI":"10.14744\/SEMB.2020.18794","article-title":"Pheochromocytoma and Paraganglioma: From Epidemiology to Clinical Findings.","volume":"54","author":"N Aygun","year":"2020 Jun 3","journal-title":"Sisli Etfal Hastan. Tip Bul."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"717-725","DOI":"10.1210\/jc.2010-1946","article-title":"Clinical risk factors for malignancy and overall survival in patients with pheochromocytomas and sympathetic paragangliomas: primary tumor size and primary tumor location as prognostic indicators.","volume":"96","author":"M Ayala-Ramirez","year":"2011 Mar","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"119-138","DOI":"10.1016\/j.soc.2015.08.006","article-title":"Pheochromocytoma and Paraganglioma: Diagnosis, Genetics, and Treatment.","volume":"25","author":"C Kiernan","year":"2016 Jan","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"552-565","DOI":"10.1056\/NEJMra1806651","article-title":"Pheochromocytoma and Paraganglioma.","volume":"381","author":"H Neumann","year":"2019 Aug 8","journal-title":"N. Engl. J. 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Surg."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"5210-5216","DOI":"10.1210\/jcem.86.11.8034","article-title":"Benign paragangliomas: clinical presentation and treatment outcomes in 236 patients.","volume":"86","author":"D Erickson","year":"2001 Nov","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"312-318","DOI":"10.1210\/jc.2018-01532","article-title":"CT Characteristics of Pheochromocytoma: Relevance for the Evaluation of Adrenal Incidentaloma.","volume":"104","author":"L Canu","year":"2019 Feb 1","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"705-706","DOI":"10.1016\/j.jtcvs.2006.02.061","article-title":"Successful perioperative management of a middle mediastinal paraganglioma.","volume":"132","author":"J Matsumoto","year":"2006 Sep","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"307-319","DOI":"10.1590\/S1677-5538.IBJU.2023.0038","article-title":"The Pheochromocytoma\/Paraganglioma syndrome: an overview on mechanisms, diagnosis and management.","volume":"49","author":"L J\u00fanior","year":"2023 May-Jun","journal-title":"Int. Braz. J. Urol."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"333-337","DOI":"10.1016\/j.ijscr.2012.03.028","article-title":"Left subdiaphragmatic paraganglioma supplied by contralateral right renal artery.","volume":"3","author":"J Martinez","year":"2012","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"898-906","DOI":"10.1007\/s00464-003-9233-3","article-title":"Fewer adhesions induced by laparoscopic surgery?","volume":"18","author":"C Gutt","year":"2004 Jun","journal-title":"Surg. Endosc."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e48-e53","DOI":"10.1097\/SLE.0b013e31820ad532","article-title":"Laparoscopic resection of abdominal paragangliomas.","volume":"21","author":"J Mitchell","year":"2011 Feb","journal-title":"Surg. Laparosc. Endosc. Percutan. 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I already addressed this questions in the new uploaded document. I am aware of any changes and requests for modifications. Regards.","URL":"https:\/\/f1000research.com\/articles\/13-1023\/v2#referee-comment-12660","order":1,"name":"referee-comment-12660","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.173558.r334842, Amjad Kanj, Mayo Clinic Minnesota, Rochester, Minnesota, 28 Oct 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1023\/v2#referee-response-334842","order":2,"name":"referee-response-334842","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.173558.r341669, Bai Ji, Jianji Ke, Jilin University, Changchun, Jilin, 05 Dec 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1023\/v2#referee-response-341669","order":3,"name":"referee-response-341669","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}