{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:07:37Z","timestamp":1772168857717,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.155381.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000}}],"reference-count":20,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T00:00:00Z","timestamp":1733097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Backround\/Objectives We investigated a technique that facilitates the coiling of a regular straight catheter (with integral stylet) behind the sciatic nerve in an ultrasound (US) regional anaesthesia simulator, and then applied our findings to a series of orthopedic-trauma patients. Methods We conducted a randomized study of two methods of perineural catheter advancement in a sciatic nerve block Blue Phantom simulator. Two groups of twenty catheters each (method A and method B) were evaluated under real-time ultrasound imaging. The needle in-plane\/nerve in-short-axis technique was applied. In method A the catheter was advanced beyond the needle tip with the integral stylet extending along its entire length; in method B the catheter was advanced after its integral stylet was retracted by 6 cm, thus providing flexibility to the catheter\u2019s distal end. Additionally, to assess the procedural effectiveness of method B coiling technique, a pilot study was conducted examining 25 perineural catheters coiled underneath the sciatic nerve in trauma-orthopaedic patients to document any catheter tip displacement from their initial position (for 36 hours postoperatively). Results In the simulation study, method B led to a significantly higher percentage (18\/20:90%) of coiled catheters than method A (3\/20:15%). Two coiled catheters of method B were found kinked\/obstructed. In our patients, after catheter insertion, the distal end of 2\/25 (8%) coiled catheters was obstructed. One perineural catheter was dislodged. For the remaining 22 (88%) catheters, ultrasound imaging demonstrated that local anaesthetic infusion made contact with the sciatic nerve, indicating no displacement of the catheter\u2019s distal end postoperatively. Conclusion Regular straight perineural catheters can be coiled if their integral stylet is partially retracted. This coiling method offers extra catheter length adjacent to the nerve structure which potentially mitigates catheter tip displacement. Trial registration clinicaltrials.gov, registration No: NCT06568510, 23\/08\/2024, registration URL: https:\/\/clinicaltrials.gov\/study\/NCT06568510?intr=coiling%20of%20echogenic%20sciatic%20nerve&amp;rank=1#study-overview<\/ns3:p>","DOI":"10.12688\/f1000research.155381.2","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T10:30:07Z","timestamp":1733135407000},"page":"1103","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Coiling of echogenic perineural catheters with integral stylet: A proof-of-concept randomized control trial in a sciatic nerve block simulator and a pilot study in orthopaedic-trauma patients."],"prefix":"10.12688","volume":"13","author":[{"given":"Theodosios","family":"Saranteas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5092-9462","authenticated-orcid":false,"given":"Eleni","family":"Poulogiannopoulou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Riga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantina","family":"Panagouli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Mavrogenis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Papadimos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2024,12,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12871-022-01700-x","article-title":"Impact of self-coiling catheters for continuous popliteal sciatic block on postoperative pain level and dislocation rate: a randomized controlled trial.","volume":"22","author":"R Nickl","year":"2022","journal-title":"BMC Anesthesiol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101341","DOI":"10.1016\/j.accpm.2023.101341","article-title":"Perineural coiled echogenic catheters with a flexible distal end: A brief technical report.","volume":"43","author":"T Saranteas","year":"2023","journal-title":"Anaesth. 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In the revised manuscript, all recommendations were considered and incorporated in the new text.&nbsp; Corrections in the text are highlighted with bold to facilitate perusal.  \n<b>1) A flow chart for both the simulation and the pilot study would be helpful (depicting number of attempts, excluded cases or any other relevant detail).<\/b> A flow chart is included in Figshare. Pilot study: Coiling of Echogenic Sciatic Nerve Perineural Catheters with Integral Stylet. https:\/\/doi.org\/10.6084\/m9.figshare.26854939.v1  \n<b>2) What statistical test did you employ for examining normal distribution of continuous variables. Please include this information in the \u201cstatistical analysis\u201d section. Moreover, the way results are presented (i.e., mean(SD) or median(IQR) for continuous data and absolute\/relative frequencies for categorical data or any other way ) should be mentioned in \u201cstatistical analysis\u201d.<\/b> Normality was assessed by D'Agostino-Pearson test and the continuous data were described as mean (range) (Statistical analysis section).  \n<b>3) In results you state \u201coxycodone consumption was 12.5 (0-20) mg \u2026\u201d. Are you referring to mean and range or median and IQR (interquartile range)? Please specify.<\/b> Oxycodone consumption is presented as mean (range: highest value-lowest value).","URL":"https:\/\/f1000research.com\/articles\/13-1103\/v2#referee-comment-12883","order":1,"name":"referee-comment-12883","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.175369.r345083, Konstantinos Kalimeris, University of Zurich, Zurich, 04 Dec 2024, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1103\/v2#referee-response-345083","order":2,"name":"referee-response-345083","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}