{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:09:04Z","timestamp":1772168944536,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.155815.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000}},{"DOI":"10.12688\/f1000research.155815.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000}},{"DOI":"10.12688\/f1000research.155815.3","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000}}],"reference-count":17,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Gastric metastasis from melanoma is rare and often presents as an unexpected finding, rarely revealing an underlying primary skin melanoma. Case presentation We report a case of a 62-year-old male who presented with abdominal pain, dyspepsia, anorexia, and weight loss. On physical examination abdominal masses and hepatomegaly were detected. Radiological imaging showed widespread masses in the abdominal and thoracic regions. Upper gastrointestinal endoscopy identified an umbilicated protruded lesion with central dark pigmentation at the antro-fundic junction. Histopathological examination and immunohistochemical staining were consistent with melanoma. A subsequent rigorous skin examination uncovered a primary malignant skin melanoma. Due to worsening general condition, the patient received palliative hospice care. Conclusion This report highlights the critical need for vigilant skin examination when dealing with widespread metastatic disease.<\/ns3:p>","DOI":"10.12688\/f1000research.155815.4","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:25:09Z","timestamp":1751516709000},"page":"1019","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Overlooked Skin Melanoma Unveiled by Gastric Metastasis"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1330-6887","authenticated-orcid":false,"given":"Ramzi","family":"Tababi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-8830","authenticated-orcid":false,"given":"Amal","family":"Khsiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moufida","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Ben Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manel","family":"Yakoubi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-4248","authenticated-orcid":false,"given":"Ghada","family":"Gharbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abir","family":"Chaabane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emna","family":"Chelbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Medhioub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6350-6779","authenticated-orcid":false,"given":"Mohamed Lamine","family":"Hamzaoui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/medsci9040063","article-title":"Epidemiology of Melanoma.","volume":"9","author":"K Saginala","year":"2021","journal-title":"Med. 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Pascale Foundation National Cancer Institute IRCCS,, Naples, 14 Jul 2025, version 4, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1019\/v4#referee-response-396415","order":0,"name":"referee-response-396415","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ramzi Tababi<\/b>; \n<i>Posted: 25 Jun 2025<\/i>; We thank the reviewer for the constructive feedback, which has been very helpful in improving our manuscript. In this revised version:  We have changed the title to \n<b>\u201cOverlooked Skin Melanoma Unveiled by Gastric Metastasis\u201d<\/b> to improve clarity and lift any confusion noted in previous versions, while preserving the intended message. As requested, we have removed the sentence referring to cytological atypia and pleomorphism as typical features of melanoma. The statement regarding phenotypic dedifferentiation of metastatic melanoma has been retained, with references 12 and 13 appropriately cited to support the information, as suggested.  We hope these revisions meet the reviewer\u2019s expectations and further enhance the clarity and value of the manuscript.","URL":"https:\/\/f1000research.com\/articles\/13-1019\/v4#referee-comment-14138","order":1,"name":"referee-comment-14138","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.171029.r322061, Hanen Jaziri, University of Sousse, Sousse, 06 Nov 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-1019\/v1#referee-response-322061","order":2,"name":"referee-response-322061","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Ramzi Tababi<\/b>; \n<i>Posted: 01 Dec 2024<\/i>; Thank you for your positive feedback. We appreciate your recognition of the rarity and significance of the case, as well as the importance of vigilant skin examination in such patients. We are also glad that the use of imaging and histological findings was well-illustrated.","URL":"https:\/\/f1000research.com\/articles\/13-1019\/v4#referee-comment-12902","order":3,"name":"referee-comment-12902","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}