{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:23:21Z","timestamp":1793193801678,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.155987.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000}}],"reference-count":35,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008463","name":"LPPM Universitas Airlangga","doi-asserted-by":"publisher","award":["No:283\/UN3.15\/PT\/2023"],"award-info":[{"award-number":["No:283\/UN3.15\/PT\/2023"]}],"id":[{"id":"10.13039\/501100008463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>Background The interaction between Streptococcus mutans (S. mutans) and Veillonella species (Veillonella spp.) is unclear. This study aims to investigate the interaction between S. mutans and Veillonella spp. on caries development using systematic review. Methods This systematic review was accorded to the guideline of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Three electronic databases, namely PubMed, Embase, and the Cochrane library, were used to conduct a systematic search for eligible studies from their inception until July 18, 2023. PROSPERO registration number was No. CRD42023445968. Results We initially identified 4,774 articles. After eliminating duplicates and irrelevant articles, 11 studies met the inclusion criteria. The studies revealed important aspects of the relationship between S. mutans and Veillonella spp. in dental caries. One significant finding is that Veillonella spp. can affect the acid production capacity of S. mutans. Some studies indicate that Veillonella spp. can inhibit the acid production by S. mutans, potentially reducing the cariogenic process. Another aspect is the competition for substrates. Veillonella spp. utilize lactic acid, which is a by product of S. mutans metabolism, as a source of carbon. This metabolic interaction may decrease the availability of lactic acid for S. mutans, potentially influencing its cariogenic potential. Conclusions This systematic review highlights the emerging evidence on the interaction between S. mutans and Veillonella spp. in dental caries. The findings suggest that Veillonella spp. can modulate the acid production, and substrate competition of S. mutans, potentially influencing the cariogenic process.<\/ns4:p>","DOI":"10.12688\/f1000research.155987.2","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T07:25:07Z","timestamp":1737617107000},"page":"1080","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["A systematic review of Streptococcus Mutans and Veillonellae species interactions in dental caries progression: Positive or Negative impact?"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-1328","authenticated-orcid":false,"given":"Faizul","family":"Hasan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5518-3372","authenticated-orcid":false,"given":"Hendrik","family":"Setia Budi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4227-0458","authenticated-orcid":false,"given":"Rajesh","family":"Ramasamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tantiana","family":"Tantiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rini Devijanti","family":"Ridwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ervina Restiwulan","family":"Winoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prawati","family":"Nuraini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2102-6141","authenticated-orcid":false,"given":"Juni","family":"Handajani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5667-9444","authenticated-orcid":false,"given":"Ariadna Adisattya","family":"Djais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-5981","authenticated-orcid":false,"given":"Silvia","family":"Anitasari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"122-128","DOI":"10.4103\/jomfp.JOMFP_304_18","article-title":"Oral microbiome: Unveiling the fundamentals.","volume":"23","author":"P Deo","year":"2019","journal-title":"J. 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We will now address the specific concerns raised.  The incorporation of clinical research literature and the constraints in establishing causal conclusions. The reliance on clinical research literature presents limitations that restrict the capacity to draw causal conclusions. The manuscript explicitly outlines this limitation. The revised text includes a discussion highlighting the necessity of robust experimental data to support causal inference.  Misinterpretation of Fundamental Principles: Gram stain and growth characteristics: Thank you for highlighting the inaccuracies in the phrasing related to gram-positive\/negative and aerobic\/anaerobic bacteria. The statement has been revised to clarify that gram-stain indicates cell wall structure, whereas aerobic\/anaerobic pertains to growth characteristics. The revised text states: &quot;Oral bacteria encompass both gram-positive and gram-negative species exhibiting varied growth characteristics, including aerobic and anaerobic organisms.&quot;  The composition of the polymicrobial community in oral biofilms and its association with periodontitis has been clarified, and we acknowledge this correction. The text has been revised to accurately state: &quot;The polymicrobial community in oral biofilms, comprising Streptococcus, Actinomyces, Lactobacillus, Veillonella, Neisseria, and Eubacterium, exists in homeostasis with the human host.&quot; Specific bacteria, including Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, exhibit a strong association with periodontitis.  Clarification regarding Streptococcus mutans (S. mutans): The characterization of S. mutans as &quot;normal flora&quot; has been refined to prevent misconceptions. The updated text specifies that S. mutans is a gram-positive facultative anaerobe typically located in the oral cavity. Under specific conditions, including inadequate oral hygiene, S. mutans may play a role in the formation of dental caries.  Oral hygiene as a predisposing factor. The statement &quot;oral hygiene is a predisposing factor&quot; is indeed ambiguous and necessitates further clarification. The updated text clarifies: &quot;Inadequate oral hygiene fosters conditions that promote the proliferation of harmful bacteria, increasing the risk of oral diseases like caries and periodontitis.&quot; The revisions aim to address the raised concerns and enhance the clarity and quality of the manuscript.","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v2#referee-comment-13121","order":1,"name":"referee-comment-13121","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.171233.r342753, Zahreni Hamzah, Yani Corvianindya Rahayu, Department of Biomedical Science, Faculty of Dentistry, University of Jember, Jember, 30 Dec 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v1#referee-response-342753","order":2,"name":"referee-response-342753","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Hendrik Setia Budi<\/b>; \n<i>Posted: 12 Jan 2025<\/i>; The authors express gratitude to the reviewer for the favorable feedback and for emphasizing the significance of this study for the dental community. We acknowledge the recommendations for enhancement and have responded to them as outlined below: We have conducted a thorough review of the manuscript and rectified all inconsistencies in the writing of S. mutans. All instances now uniformly adhere to the correct format. S. mutans. Consistency in Writing Veillonella spp.: We have maintained uniformity in the representation of Veillonella spp. throughout the manuscript. All inconsistencies have been addressed. We anticipate that these revisions will fulfill your expectations and improve the manuscript's quality. I appreciate your insightful comments and suggestions.","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v2#referee-comment-13119","order":3,"name":"referee-comment-13119","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.171233.r350938, Fidya Fidya, Universitas Brawijaya, Malang, East Java, 08 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v1#referee-response-350938","order":4,"name":"referee-response-350938","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Hendrik Setia Budi<\/b>; \n<i>Posted: 12 Jan 2025<\/i>; Thank you for the review and acknowledgement.","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v2#referee-comment-13120","order":5,"name":"referee-comment-13120","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.171233.r350940, Atik Kurniawati, Yohana Maria Penga, Sari Setyaningsih, Universitas Jember, Jember, East Java, 23 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1080\/v1#referee-response-350940","order":6,"name":"referee-response-350940","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"HSB received funding from Airlangga University and The Indonesian Ministry of Research, Technology and Higher Education (Ristekdikti). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":7,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}