{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:01:49Z","timestamp":1767178909803,"version":"build-2238731810"},"update-to":[{"DOI":"10.12688\/f1000research.15662.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000}},{"DOI":"10.12688\/f1000research.15662.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000}}],"reference-count":16,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>\n                    <ns4:bold>Background:<\/ns4:bold>\n                    Hypokalemic periodic paralysis (HypoKPP) is characterized by transient episodes of flaccid muscle weakness. We describe the case of a teenaged boy with HypoKPP and hyperthyroidism due to Hashimoto's thyroiditis with initial manifestation of renal tubular acidosis. This combination is rare and little described previously in men.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Case presentation<\/ns4:bold>\n                    : A 17-year-old boy was admitted after three days of muscular weakness and paresthesia in the lower limbs with an ascending evolution, leading to prostration. Decreased strength was found in the lower limbs without a defined sensory level, reduced patellar and ankle reflexes. Positive antithyroid antibodies were found. He received hydration treatment, IV potassium and levothyroxine, with which there was a clinical improvement. Other examinations led to the diagnosis of type 1 renal tubular acidosis.\n                  <\/ns4:p>\n                  <ns4:p>\n                    <ns4:bold>Conclusion<\/ns4:bold>\n                    : HypoKPP is a rare disorder characterized by acute episodes of muscle weakness. Type 1 renal tubular acidosis can occur as a consequence of thyroiditis, which is explained by the loss of potassium. This combination is unusually rare, and has not been described before in men. The etiopathogenesis of the disease as well as a dynamic explanation of what happened with the patient are discussed in this report.\n                  <\/ns4:p>","DOI":"10.12688\/f1000research.15662.3","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T04:16:21Z","timestamp":1547525781000},"page":"1154","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Recurrent hypokalemic periodic paralysis associated with distal renal tubular acidosis (type 1) and hypothyroidism secondary to Hashimoto's thyroiditis"],"prefix":"10.12688","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5593","authenticated-orcid":false,"given":"E. Dante","family":"Meregildo-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2992-9342","authenticated-orcid":false,"given":"Virgilio E.","family":"Failoc-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"ref-1","article-title":"Hypokalemic periodic paralysis.","author":"J Wilterdink"},{"key":"ref-2","doi-asserted-by":"publisher","DOI":"10.1177\/1179544117722763","article-title":"Hypokalemic Paralysis: A Hidden Card of Several Autoimmune Diseases.","volume":"10","author":"Y Velarde-Mej\u00eda","year":"2017","journal-title":"Clin Med Insights Arthritis Musculoskelet Disord."},{"key":"ref-3","first-page":"1014-1016","article-title":"Distal renal tubular acidosis and hypokalemic paralysis in a patient with hypothyroidism.","volume":"22","author":"P 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hypothyroidism.","volume":"17","author":"U Sinha","year":"2013","journal-title":"Indian J Endocrinol Metab."},{"key":"ref-7","first-page":"79-81","article-title":"Hypokalaemic Periodic Paralysis Associated with Hypothyroidism.","volume":"23","author":"T Singh","year":"2012","journal-title":"Indian J Phys Med Rehabil."},{"key":"ref-8","doi-asserted-by":"publisher","first-page":"164-166","DOI":"10.15197\/sabad.1.12.33","article-title":"Hypokalemic Periodic Paralysis Due To Distal Renal Tubular Acidosis.","volume":"12","author":"E G\u00fcnd\u00fcz","year":"2015","journal-title":"Eur J Gen Med."},{"key":"ref-9","first-page":"569-70","article-title":"[Hypokalemia, distal renal tubular acidosis, and Hashimoto's thyroiditis].","volume":"28","author":"B Finn","year":"2008","journal-title":"Nefrologia."},{"key":"ref-10","article-title":"Etiology and diagnosis of distal (type 1) and proximal (type 2) renal tubular acidosis.","author":"M Emmett"},{"key":"ref-11","doi-asserted-by":"publisher","first-page":"289-96","DOI":"10.3265\/Nefrologia.pre2012.Oct.11592","article-title":"Distal renal tubular acidosis: a hereditary disease with an inadequate urinary H\u207a excretion.","volume":"33","author":"L Escobar","year":"2013","journal-title":"Nefrologia."},{"key":"ref-12","first-page":"5-7","article-title":"Hypokalemia paralyzing revealing a rare association of autoimmune diseases: type 1 diabetes, thyroiditis and tubulopathy about a case.","volume":"5","author":"M Suzanne","year":"2015","journal-title":"IOSR Journal Of Pharmacy."},{"key":"ref-13","doi-asserted-by":"publisher","first-page":"862-4","DOI":"10.4103\/jfmpc.jfmpc_215_17","article-title":"Sporadic hypothyroidism-related hypokalemic paralysis: Diagnosis in a resource-poor setting.","volume":"6","author":"N Kadeeja","year":"2017","journal-title":"J Family Med Prim Care."},{"key":"ref-14","doi-asserted-by":"crossref","DOI":"10.1097\/00000441-195909000-00030","article-title":"Radiographic atlas of skeletal development of the hand and wrist","author":"W Greulich","year":"1959"},{"key":"ref-15","doi-asserted-by":"publisher","first-page":"2160-70","DOI":"10.1097\/01.ASN.0000023430.92674.E5","article-title":"Renal tubular acidosis: the clinical entity.","volume":"13","author":"J Rodr\u00edguez Soriano","year":"2002","journal-title":"J Am Soc Nephrol."},{"key":"ref-16","article-title":"Agreement Between Chronological Age and Bone Age Based on the Greulich and Pyle Atlas for Age Estimation: A Systematic Review [Internet]","author":"P Dahlberg","year":"2017"}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T04:16:25Z","timestamp":1547525785000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,15]]},"references-count":16,"URL":"https:\/\/doi.org\/10.12688\/f1000research.15662.3","relation":{},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,15]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.17089.r37480, Cristian D\u00edaz-V\u00e9lez, Centro de Investigaci\u00f3n en Epidemiolog\u00eda Cl\u00ednica y Medicina Basada en Evidencias, Instituto de Investigaci\u00f3n, Facultad de Medicina Humana, Universidad de San Mart\u00edn de Porres, Chiclayo, Peru, 31 Oct 2018, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/7-1154\/v1#referee-response-37480","order":0,"name":"referee-response-37480","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Virgilio E Failoc-Rojas<\/b>; \n<i>Posted: 16 Dec 2018<\/i>; Dear Dr Cristian.&nbsp;Answering your questions.1) For a new version, the reference values will be added and expressed in mmol\/ L2) The delays in bone maturation, evaluable by bone age and the failure of bone growth are typical alterations of distal renal tubular acidosis. This is explained in the penultimate paragraph.3) Most autoimmune disorders, including are more common in women.","URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3#referee-comment-4307","order":1,"name":"referee-comment-4307","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.19283.r42522, Stalin Viswanathan, Department of General Medicine, JIPMER, Puducherry, Puducherry, India, 07 Jan 2019, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/7-1154\/v2#referee-response-42522","order":2,"name":"referee-response-42522","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Virgilio E Failoc-Rojas<\/b>; \n<i>Posted: 11 Jan 2019<\/i>; Thank you very much for your suggestions, they have been accepted and modified accordingly, the term DRTA is standardized.","URL":"https:\/\/f1000research.com\/articles\/7-1154\/v3#referee-comment-4354","order":3,"name":"referee-comment-4354","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}