{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:29Z","timestamp":1772168909660,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.156703.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000}}],"reference-count":50,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016175","name":"Chulabhorn Royal Academy","doi-asserted-by":"publisher","award":["RAA2564\/058"],"award-info":[{"award-number":["RAA2564\/058"]}],"id":[{"id":"10.13039\/100016175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns5:p>\n                    Introduction Psoriasis is a chronic skin disease affecting quality of life and causing pruritus. The factors influencing itch and its impact on the quality of life in Thai psoriasis patients are unknown. We aimed to identify these factors and their effect on quality of life. Methods In this questionnaire-based cross-sectional study, we included patients with psoriasis who received treatment at Chulabhorn Hospital in Thailand from January 2019 to July 2021. Interviewer is the non-dermatologist practician. The patient\u2019s information was collected, including demographic data, Itch Numeric Rating Scale (Itch NRS) score, factors affecting itch, and score on the Thai version of the Dermatology Life Quality Index (DLQI). We performed descriptive statistics and logistic regression analysis. Results Of 100 participants, most (99%) experienced itching, with a moderate degree of pruritus (mean Itch NRS score 6.5 \u00b1 2.6) and a moderate effect on quality of life (mean DLQI score 9.4 \u00b1 6.2). Factors associated with itch aggravation were dry skin (p-value = 0.003) and heat and humidity (p-value = 0.042). The results of binary logistic regression revealed that factors associated with moderate-to-extremely large DLQI scores were itch intensity (no-to-mild vs. moderate-to-severe itch: odds ratio [OR] = 13.33; 95% confidence interval [CI] = 2.72\u201365.32,\n                    <ns5:italic>p<\/ns5:italic>\n                    &lt; 0.001; and adjusted odds ratio [AOR] = 31.17; 95% CI = 4.55\u2013213.36;\n                    <ns5:italic>p<\/ns5:italic>\n                    &lt; 0.001. Conclusions Our findings revealed that the quality of life among patients with psoriasis is their greatest concern. Eliminating the itch intensity that affects their quality of life is crucial but remains challenging in Thailand.\n                  <\/ns5:p>","DOI":"10.12688\/f1000research.156703.2","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T11:40:10Z","timestamp":1745581210000},"page":"1242","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Factors Affecting Itching and Quality of Life in Thai Patients with Psoriasis: A Cross-Sectional Study"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-1997","authenticated-orcid":false,"given":"Phurichaya","family":"Teyateeti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9698-7165","authenticated-orcid":false,"given":"Chanita","family":"Autchayawat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-5173","authenticated-orcid":false,"given":"Wiriya","family":"Mahikul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3136-3898","authenticated-orcid":false,"given":"Rithee","family":"Smithrithee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"377-85","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence.","volume":"133","author":"R Parisi","year":"2013 Feb","journal-title":"J. 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[database on the Internet].","year":"2024 cited 2024 Oct 7","journal-title":"figshare."},{"key":"ref50","article-title":"Questionniare.docx. [database on the Internet].","year":"2024 cited 2024 Oct 7","journal-title":"figshare."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T01:45:08Z","timestamp":1748051108000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":50,"URL":"https:\/\/doi.org\/10.12688\/f1000research.156703.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.156703.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.181039.r381203","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.181039.r380765","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.181039.r380765","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.181039.r381203","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.172051.r364699, Napatra Tovanabutra, Chiang Mai University, Chiang Mai, Chiang Mai, 28 Feb 2025, version 1, 2 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-1242\/v1#referee-response-364699","order":0,"name":"referee-response-364699","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Wiriya Mahikul<\/b>; \n<i>Posted: 03 Mar 2025<\/i>; \n<b>Reviewer 1 <\/b> Napatra Tovanabutra, Chiang Mai University, Chiang Mai, Chiang Mai, Thailand Approved With Reservations  info_outline \n<b>Overall, this is a well-written manuscript which evaluates the association between factors affecting itch and quality of life in Thai patient with psoriasis. The result of the analysis seems accurate. The following are minor comments which need to be addressed and revised.<\/b> Thank you for the positive reviews on our manuscript and for the reviewers\u2019 comments on how to improve the publication.  \n<b>Due to this study allowing the patient response to the questionnaire by telephone, it would be good if the authors can report the number of patients who response by the different methods and whether the difference of the results between these two methods.<\/b> Thank you for your comments. We agree with the reviewer. Upon rechecking the data, we found that approximately 90% of participants were assessed via telephone interviews for itchiness and quality of life due to the survey being conducted during the COVID-19 pandemic, while only 10% participated in face-to-face interviews. This small proportion of face-to-face interviews was insufficient to perform a subgroup analysis comparing the two methods. We have clarified this in the Survey Procedures and Limitations sections, as follows: Survey procedures: ' Each patient responded to the questionnaire by telephone (90%) or face-to-face (10%) with a non-dermatologist interviewer to avoid any bias.' - line 78-79 Limitation: 'Lastly, this study used a telephone-based cross-sectional survey method during the COVID-19 pandemic to minimize the risk of transmission. As a result, causal relationships could not be established, and the sample was limited to individuals with telephone access. Therefore, the findings may not fully represent the entire population.' - line 286-289  \n<b>Authors should demonstrate the sample-size calculations.<\/b> Thank you for your comments. We have provided the sample size calculation as follows: 'To estimate the sample size, we used the infinite population proportion formula: n = Z&sup2;p(1-p)\/d&sup2;. Based on the assumption that 67% of patients reported a moderate to extremely large impact on their quality of life (DLQI &gt; 6) \n<sup>1<\/sup>, a 10% precision (d), a 95% confidence level, and accounting for a 10% non-response rate, the minimum calculated sample size was 95. The response rate was determined by dividing the number of respondents by the total number invited to the study. For example, 100 out of 125 individuals responded, yielding an 80% response rate. However, the total number of respondents still exceeds the sample size required to ensure sufficient statistical power for the study.' - line 68-75  \n<b>According to the study involved Thai patients, Asian-Pacific BMI should be used instead of WHO BMI.<\/b> We agree with the reviewer. Therefore, we changed the BMI classification from the WHO BMI to the Asian-Pacific BMI, as the study involved Thai patients, as follows: 'Patients mean body mass index (BMI) was 25.0 &plusmn; 4.4 kg\/m\n<sup>2<\/sup>, which is classified as obese (BMI \u226525 kg\/m\n<sup>2<\/sup> according to Asia Pacific guidelines) \n<sup>2<\/sup>. Of the total, 45% of participants had a BMI of \u2265 25.0 kg\/m\n<sup>2<\/sup>, which is recognized as obese (BMI \u2265 25 kg\/m\n<sup>2<\/sup>) \n<sup>2<\/sup>.' - line 117-119 and Table 1 \n<b>Table 1.<\/b> Demographic data of patients (N = 100) Variables&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; N = % BMI (kg\/m\n<sup>2<\/sup>) &nbsp; Mean &plusmn; SD&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp;&nbsp;25.0 &plusmn; 4.4 &nbsp;&nbsp; &lt; 18.5 (Underweight)&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; 2 &nbsp;&nbsp; 18.5\u201322.9 (Normal)&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; 35 &nbsp;&nbsp; 23\u201324.9 (Overweight)&nbsp; &nbsp; &nbsp; &nbsp; &nbsp;18 &nbsp;&nbsp; \u2265 25.0 (Obese)&nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; &nbsp; 45  However, this change does not affect our main results, as there is still no significant difference between BMI and DLQI. Is the work clearly and accurately presented and does it cite the current literature? Yes Is the study design appropriate and is the work technically sound? Yes Are sufficient details of methods and analysis provided to allow replication by others? Yes If applicable, is the statistical analysis and its interpretation appropriate? I cannot comment. A qualified statistician is required. Are all the source data underlying the results available to ensure full reproducibility? Yes Are the conclusions drawn adequately supported by the results? Yes  Competing Interests No competing interests were disclosed. Reviewer Expertise Dermatologist I confirm that I have read this submission and believe that I have an appropriate level of expertise to confirm that it is of an acceptable scientific standard, however I have significant reservations, as outlined above.   \n<b>Reference<\/b> 1.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Lin TY, See LC, Shen YM, Liang CY, Chang HN, Lin YK. Quality of life in patients with psoriasis in northern Taiwan. Chang Gung Med J. 2011 Mar-Apr;34(2):186-96. PubMed PMID: 21539761. Epub 2011\/05\/05. 2.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Consultation WHOE. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004 Jan 10;363(9403):157-63. PubMed PMID: 14726171. Epub 2004\/01\/17.","URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2#referee-comment-13452","order":1,"name":"referee-comment-13452","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.181039.r380765, Narumol Silpa-archa, Dermatology Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Mahidol University,, 14 May 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2#referee-response-380765","order":2,"name":"referee-response-380765","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.181039.r381203, Adam Reich, Department of Dermatology, University of Rzesz\u00f3w, Rzesz\u00f3w, 24 May 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1242\/v2#referee-response-381203","order":3,"name":"referee-response-381203","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"Chulabhorn Royal Academy-\nRAA 2564\/058. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}