{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:49:09Z","timestamp":1793321349821,"version":"4.5.0"},"update-to":[{"DOI":"10.12688\/f1000research.157194.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000}}],"reference-count":137,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background The growing incidence of chronic diseases such as cancer and the emergence of drug-resistant microorganisms constitute one of the greatest health challenges of the 21st century. Therefore, it is critical to search for new therapeutic alternatives.\n                    <ns3:italic>Moringa oleifera<\/ns3:italic>\n                    is a plant well known for the properties of its phytocomponents and its role has been analyzed in a variety of fields, from medicine to biotechnology. Methods In this work, the biological activity of\n                    <ns3:italic>Moringa oleifera<\/ns3:italic>\n                    in human health was explored through a review of 129 original articles published between 2010 and 2021 related to antitumor activity and its potential uses against chronic and infectious diseases. Results\n                    <ns3:italic>Moringa oleifera<\/ns3:italic>\n                    extracts showed antioxidant, hypoglycemic, antihypertensive and cytoprotective properties at neuronal, hepatic, renal and cardiac levels. Besides, cytotoxic effects, apoptotic and antiploriferative activity against several cancer cell lines has been demonstrated. On the other hand, the antimicrobial potential of\n                    <ns3:italic>M. oleifera<\/ns3:italic>\n                    was also evidenced, especially against multidrug-resistant strains. Conclusions Hence, it is supported that there is a wide range of clinical entities in which\n                    <ns3:italic>Moringa oleifera<\/ns3:italic>\n                    exhibits significant biological activity that could contribute to counteracting metabolic, infectious and chronic diseases in a similar or improved way to the drugs traditionally used.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.157194.2","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:25:09Z","timestamp":1738236309000},"page":"1390","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Biological properties of Moringa oleifera: A systematic review of the last decade"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4786-3431","authenticated-orcid":false,"given":"Javier Andr\u00e9s","family":"Soto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Catalina","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryeli","family":"V\u00e1squez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Natalia","family":"Barreto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Shirley","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2545-8304","authenticated-orcid":false,"given":"C. 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Campus Universitario de Espinardo, Murcia, 14 Dec 2024, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1390\/v1#referee-response-342878","order":0,"name":"referee-response-342878","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>C. A. Zuniga-Gonzalez<\/b>; \n<i>Posted: 18 Jan 2025<\/i>; We sincerely thank the reviewer for their insightful and constructive feedback, which has significantly contributed to improving the quality of our manuscript. Your suggestions to clearly emphasize the novelty and added value of our review compared to existing literature and to address the limitations of \n<i>Moringa oleifera<\/i> have been invaluable. These recommendations will guide us in refining our analysis and ensuring a balanced presentation of findings.","URL":"https:\/\/f1000research.com\/articles\/13-1390\/v2#referee-comment-13167","order":1,"name":"referee-comment-13167","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.172612.r355204, Francisco Osorio-Acosta, Veracruz campus, Veracruz, 16 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1390\/v1#referee-response-355204","order":2,"name":"referee-response-355204","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>C. A. Zuniga-Gonzalez<\/b>; \n<i>Posted: 18 Jan 2025<\/i>; Thank you very much for your thorough review and constructive comments. We greatly appreciate your suggestions, and we have addressed all of the points you raised. The English writing has been revised for better clarity and connection between ideas, and we have corrected the use of scientific names, ensuring proper italics are used. We have also reviewed and standardized the abbreviations throughout the paper, making sure they are consistently applied. Regarding the issues with Figure 1, it has been moved to the appropriate section. Additionally, we included the necessary bibliography in the 1.3 section and corrected the redaction in section 3.2, as you suggested. All these improvements have been made to enhance the overall quality of the manuscript.","URL":"https:\/\/f1000research.com\/articles\/13-1390\/v2#referee-comment-13169","order":3,"name":"referee-comment-13169","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.172612.r355211, Pradeep Singh, Debre Tabor University, Debre Tabor, Amhara, 30 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1390\/v1#referee-response-355211","order":4,"name":"referee-response-355211","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}