{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:52:22Z","timestamp":1776091942201,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.158137.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns7:p>\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    is an uncommon nosocomial pathogen that causes meningitis, pneumonia, and sepsis in neonates and in immunocompromised individuals. It exhibits resistance to many commonly employed first-line antibiotics used to treat gram-negative pathogens. Herein, we present three cases of late-onset sepsis with multi-drug resistant (MDR)\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    in high-risk neonates. Case 1 was a one-day-old preterm low-birth-weight infant who presented with respiratory distress syndrome and septic shock. The patient was intubated and administered empirical broad-spectrum antibiotics and antifungal agents. Blood culture grew\n                    <ns7:italic>Candida krusei,<\/ns7:italic>\n                    hence Amphotericin B was initiated. Repeat blood culture on day 27 showed gram-negative bacilli, identified as\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    by MALDI-TOF\n                    <ns7:italic>.<\/ns7:italic>\n                    Antibiotic susceptibility testing (AST) revealed resistance to Piperacillin\/Tazobactam, but sensitivity to Vancomycin, Levofloxacin, and Minocycline. IV Vancomycin was administered, which resulted in clinical improvement and negative blood culture results. Case 2 was an eleven-day-old preterm, low-birth-weight baby who presented with fever. Initial investigations revealed normal complete blood counts (CBC) parameters and elevated CRP levels. Blood and CSF cultures isolated\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    with a similar AST pattern. Intravenous Ciprofloxacin was initiated with clinical improvement and negative follow-up blood cultures. Case 3 was a one-day-old preterm baby, appropriate-to-gestational age, presenting with respiratory distress syndrome. The infant was intubated and started on inotropic support and intravenous antibiotics. Blood cultures on day 4 showed\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    and Vancomycin was started. Follow-up cultures on days 6 and 14 grew\n                    <ns7:italic>Acinetobacter baumannii.<\/ns7:italic>\n                    A combination of Levofloxacin and Colistin was added, and blood cultures were negative after seven days, with clinical improvement.\n                    <ns7:italic>Elizabethkingia meningoseptica<\/ns7:italic>\n                    is a significant cause of hospital-acquired infections, especially in Neonatal Intensive Care Unit (NICU), leading to outbreaks. Clinicians must have a high degree of suspicion of\n                    <ns7:italic>E. meningoseptica<\/ns7:italic>\n                    for gram-negative bacilli causing sepsis and meningitis in high-risk patients. Recent technological advances have enabled accurate speciation to guide therapy and reduce morbidity and mortality rates.\n                  <\/ns7:p>","DOI":"10.12688\/f1000research.158137.2","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T11:10:08Z","timestamp":1738840208000},"page":"1367","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["\u201cUnmasking the Uncommon\u201d: A case series of multi-drug resistant Elizabethkingia meningoseptica causing late-onset sepsis and meningitis in preterm neonates"],"prefix":"10.12688","volume":"13","author":[{"given":"Prajnha","family":"U.P.","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-975X","authenticated-orcid":false,"given":"Anisha Maria","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-0097","authenticated-orcid":false,"given":"Suchitra","family":"Shenoy M.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinchana","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"070-073","DOI":"10.1055\/s-0041-1724234","article-title":"Intrinsically resistant bacteria as looming disaster: a rare case report of Elizabethkingia meningoseptica meningitis in a neonate.","volume":"13","author":"P Patro","year":"2021 Feb 22","journal-title":"J. Lab. Physicians."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34361","article-title":"Multi-Drug-Resistant Elizabethkingia meningoseptica: A Rare Cause of Late-Onset Sepsis in a Preterm Neonate.","volume":"15","author":"A Hashmi","year":"2023 Jan 29","journal-title":"Cureus."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"100798","DOI":"10.1016\/j.nmni.2020.100798","article-title":"Clinical profile, susceptibility patterns, speciation and follow up of infections by Elizabethkingia species: study on a rare nosocomial pathogen from an intensive care unit of north India.","volume":"38","author":"S Singh","year":"2020 Nov 1","journal-title":"New Microbes New Infect."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"256-261","DOI":"10.4266\/acc.2020.01158","article-title":"Clinical features and outcomes of critically ill patients with Elizabethkingia meningoseptica: an emerging pathogen.","volume":"36","author":"A Umair","year":"2021 Jul 26","journal-title":"Acute Crit. Care."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"964046","DOI":"10.3389\/fpubh.2022.964046","article-title":"Epidemiological, clinical, and laboratory features of patients infected with Elizabethkingia meningoseptica at a tertiary hospital in Hefei City, China.","volume":"10","author":"Y Li","year":"2022 Sep 20","journal-title":"Front. Public Health."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"304-307","DOI":"10.4103\/0972-5229.120323","article-title":"Elizabethkingia meningoseptica: Emerging nosocomial pathogen in bedside hemodialysis patients.","volume":"17","author":"M Ratnamani","year":"2013 Sep","journal-title":"Indian J. Crit. Care Med."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"10-128","DOI":"10.1128\/JCM.00730-20","article-title":"Comparative genomics and antimicrobial resistance profiling of Elizabethkingia isolates reveal nosocomial transmission and in vitro susceptibility to fluoroquinolones, tetracyclines, and trimethoprim-sulfamethoxazole.","volume":"58","author":"D Burnard","year":"2020 Aug 24","journal-title":"J. Clin. Microbiol."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e02541-21","DOI":"10.1128\/jcm.02541-21","article-title":"Antimicrobial susceptibility of Elizabethkingia species: report from a reference laboratory.","volume":"60","author":"I Comba","year":"2022 Jun 15","journal-title":"J. Clin. Microbiol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"507-511","DOI":"10.1016\/j.ijantimicag.2017.06.021","article-title":"Role of vancomycin in the treatment of bacteraemia and meningitis caused by Elizabethkingia meningoseptica.","volume":"50","author":"S Jean","year":"2017 Oct 1","journal-title":"Int. J. Antimicrob. Agents."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"dlae161","DOI":"10.1093\/jacamr\/dlae161","article-title":"Elizabethkingia bloodstream infections in severely immunocompromised patients: persistent, relapsing and associated with high mortality.","volume":"6","author":"M Fahmy","year":"2024 Oct","journal-title":"JAC Antimicrob. Resist."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e416","DOI":"10.5001\/omj.2022.21","article-title":"Elizabethkingia Meningoseptica Infection in Neonates: Two Case Reports from the Eastern Region of Oman.","volume":"37","author":"K Almatari","year":"2022 Sep","journal-title":"Oman Med. J."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T15:40:11Z","timestamp":1755618011000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.158137.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.158137.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.177523.r364980","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.177523.r364980","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.173690.r341910, Godwin Justus Wilson, Hamad Medical Corporation, Weil Cornell Medical College, Ar-Rayyan, 25 Nov 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-1367\/v1#referee-response-341910","order":0,"name":"referee-response-341910","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.177523.r364980, Mark Fahmy, The University of Queensland, Saint Lucia, Queensland, 11 Feb 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1367\/v2#referee-response-364980","order":1,"name":"referee-response-364980","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}