{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:42:38Z","timestamp":1790376158508,"version":"4.1.0"},"update-to":[{"DOI":"10.12688\/f1000research.158890.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000}},{"DOI":"10.12688\/f1000research.158890.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000}}],"reference-count":61,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The publication of the research will be financed by the Vice-presidency of Research of the Universidad C\u00e9sar Vallejo, within the framework of support for teaching research."}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Background Dengue infection during pregnancy increases the risk of maternal and neonatal complications; therefore, the objective of this research is to determine these outcomes and describe the clinical manifestations of the infection. Methods A systematic review of studies published in PubMed, MEDLINE, LILACS, Web of Science, Scopus and thesis repositories published between 2013 and October 2023 was performed. DeCS and MeSH dengue and maternal-neonatal outcome were used. Thirteen studies were selected and the New Castle-Ottawa scale was used to assess their quality. Mantel-Haenszel hazard ratios were calculated to report the overall effect size using random-effects models. All analyses were performed in Rev Man 5.4.1 Results The 13 studies involved a population of 18,724 pregnant women, with cohorts ranging from 25 to 17,673 pregnant women. The most frequent outcomes in the pregnant women were cesarean section and postpartum hemorrhage, and in the newborns, preterm delivery and low birth weight. According to the New Castle-Ottawa scale, six studies were considered low risk and seven studies moderate risk. Dengue is a risk factor for postpartum hemorrhage (OR: 2.23 IC 0.24 \u2013 20.38), premature rupture of membranes (OR: 1.04 IC 0.55-1.97) and cesarean section (OR: 1.39 IC 0.80 \u2013 2.41). It could not be concluded that dengue is a risk factor for the neonatal outcomes studied. The clinical picture of pregnant women with dengue was predominantly fever, abdominal pain, vomiting and nausea, anemia, dyspnea and myalgia. Conclusions Pregnancy-related changes in the immune, cardiovascular and coagulation systems, among others, increase the probability of adverse maternal and neonatal outcomes in case of DENV infection, such as postpartum hemorrhage, premature rupture of membranes, cesarean section, low birth weight and preterm delivery. Pregnant women should be considered a population at risk and should be included in dengue control, diagnosis and treatment policies.<\/ns3:p>","DOI":"10.12688\/f1000research.158890.3","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T19:20:09Z","timestamp":1763666409000},"page":"1523","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Dengue infection during pregnancy and the occurrence of pathological neonatal outcome: a\u00a0systematic review and meta-analysis"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9994-9184","authenticated-orcid":false,"given":"Evelyn del Socorro","family":"Goicochea-R\u00edos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-4847","authenticated-orcid":false,"given":"NELIDA MILLY","family":"OTINIANO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lola del Carmen","family":"Rojas-Infantas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6518-4926","authenticated-orcid":false,"given":"V\u00edctor Ra\u00fa","family":"Oca\u00f1a-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00e9stor Iv\u00e1n","family":"G\u00f3mez-Goicochea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"100288","DOI":"10.1016\/j.puhip.2022.100288","article-title":"A case-control study to determine the risk factors of dengue fever in Chattogram, Bangladesh.","volume":"4","author":"M Rahman","year":"2022","journal-title":"Public Health Pract (Oxf)."},{"key":"ref2","doi-asserted-by":"publisher","article-title":"Riesgo de presentaci\u00f3n de brotes de gran magnitud de dengue, en regiones del pa\u00eds por fen\u00f3meno del Ni\u00f1o Costero. 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We greatly appreciate your comments and suggestions and would like to inform you that we will be making the changes indicated in the article in order to improve it.","URL":"https:\/\/f1000research.com\/articles\/13-1523\/v3#referee-comment-14356","order":2,"name":"referee-comment-14356","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The publication of the research will be financed by the Vice-presidency of Research of the Universidad C\u00e9sar Vallejo, within the framework of support for teaching research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}