{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:15:21Z","timestamp":1788167721390,"version":"build-2803163510"},"update-to":[{"DOI":"10.12688\/f1000research.159059.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000}}],"reference-count":39,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Phyllodes tumor of the breast is a rare fibroepithelial tumor, constituting less than 1% of all breast neoplasms. These tumors are characterized by rapid stromal growth and can reach significant sizes, particularly in malignant cases, necessitating aggressive surgical management due to their high recurrence risk. In this case report, we present a 40-year-old Tunisian woman diagnosed with a giant phyllodes sarcoma. The patient experienced considerable physical and psychological impacts, including impaired mobility, body image disruption, and professional limitations. Clinical examination and imaging confirmed the presence of a large lobulated mass in the left breast, with no signs of distant metastasis. A multidisciplinary team recommended a total mastectomy with immediate reconstruction using a latissimus dorsi myocutaneous flap. This approach aimed to restore breast contour while addressing both oncologic and aesthetic needs. The procedure was successful, with the excised tumor weighing 7 kg. Postoperatively, the patient received close monitoring and psychological support, emphasizing the importance of a holistic approach to recovery. This case underscores the complexities of managing giant phyllodes sarcoma, highlighting the value of a timely surgical intervention combined with effective reconstructive techniques. It also emphasizes the need for individualized treatment plans that consider both functional and aesthetic outcomes to optimize patient recovery and quality of life<\/ns3:p>","DOI":"10.12688\/f1000research.159059.2","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T10:54:07Z","timestamp":1786186447000},"page":"130","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Giant Malignant Phyllodes Tumor of the Breast: Immediate Reconstruction with a Pedicled Latissimus Dorsi Myocutaneous Flap Following Total Mastectomy\u2014A Case Report and Review of Reconstructive Considerations"],"prefix":"10.12688","volume":"14","author":[{"given":"Dhekra","family":"Toumi","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Monastir Monastir 5030 Faculty of Medicine, Monastir Maternity and Neonatology Centre, University of 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Treat."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"3004-3013","DOI":"10.1016\/j.bjps.2022.06.052","article-title":"Total breast reconstruction with the fat-augmented latissimus dorsi (FALD) flap: High safety in a single-center uncontrolled case series.","volume":"75","author":"F Santanelli di Pompeo","year":"sept. 2022","journal-title":"J Plast Reconstr Aesthet Surg."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"4S-12S","DOI":"10.1097\/PRS.0000000000009494","article-title":"Oncologic Outcome of 1000 Postmastectomy Breast Reconstructions with Fat Transfer: A Single-Center, Matched Case-Control Study.","volume":"150","author":"M Sorotos","year":"2022","journal-title":"Plast Reconstr Surg."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"674-676","DOI":"10.1007\/s10330-010-0688-0","article-title":"Giant phyllodes tumor of the breast: a case report.","volume":"9","author":"D Xia","year":"2010","journal-title":"Chinese-German Journal of Clinical Oncology."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/14-130\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-130\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-130\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:24:09Z","timestamp":1788164649000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/14-130\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,8]]},"references-count":39,"URL":"https:\/\/doi.org\/10.12688\/f1000research.159059.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.159059.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.207721.r509141","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.207721.r515771","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.207721.r515771","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.207721.r509141","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,8]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/14-130\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.207721.r509141, Guido Firmani, Sapienza University Rome, Rome, 19 Aug 2026, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-130\/v2#referee-response-509141","order":0,"name":"referee-response-509141","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.207721.r515771, Nesrine SOUAYEH, Ben Arous R\u00e9gional Hospital, Obstetrics and Gynaecology Department. Faculty of Medicine, University of Tunis el Manar, Tunis, 31 Aug 2026, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-130\/v2#referee-response-515771","order":1,"name":"referee-response-515771","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":2,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}