{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:53Z","timestamp":1772168933518,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.159445.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000}}],"reference-count":11,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:00:00Z","timestamp":1760400000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Tracheobronchial endoluminal hamartochondroma (HC) is a rare benign tumor, most frequently diagnosed in individuals between the sixth and seventh decades of life. The clinical presentation is usually very noisy. Here, we report two interesting cases. The first patient is a 58-year-old man who was wrongly treated for chronic obstructive pulmonary disease. HC was in the lower third of the trachea. The second patient is a 43-year-old man with a history of bronchiectasis and right lower lobectomy. HC was in the middle lobe bronchus. The resection via rigid bronchoscopy with diode laser was successful without any complications. Only one patient keeps a small stable tumor residue. The rigid bronchoscopy with laser-application in tracheobronchial endoluminal HC is safe and effective. Flexible bronchoscopy is important during the follow-up.<\/ns3:p>","DOI":"10.12688\/f1000research.159445.2","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T16:25:09Z","timestamp":1760459109000},"page":"76","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Tracheobronchial endoluminal hamartochondroma resected via rigid bronchoscopy: 2 case reports of a rare entity"],"prefix":"10.12688","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-3399","authenticated-orcid":false,"given":"Amany","family":"Touil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maazaoui","family":"Sarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darragi","family":"Karim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaabane","family":"Mariem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5318-5545","authenticated-orcid":false,"given":"Znegui","family":"Tasnim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6138-0504","authenticated-orcid":false,"given":"Ayadi","family":"Rahma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fitouhi","family":"Nizar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baccouche","family":"Ines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Racil","family":"Hager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5323-3025","authenticated-orcid":false,"given":"Chaouch","family":"Nawel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"key":"ref1","first-page":"72-76","article-title":"Roentgen morphology and clinical picture of pulmonary hamartochondroma.","volume":"38","author":"F Grabenw\u00f6ger","year":"1985 Mar","journal-title":"Rontgenblatter."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"14-20","DOI":"10.4065\/71.1.14","article-title":"Pulmonary Hamartomas.","volume":"71","author":"J Gjevre","year":"1996 Jan 1","journal-title":"Mayo Clin. Proc."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1744-1751","DOI":"10.1378\/chest.107.6.1744","article-title":"Benign Tumors of the Tracheobronchial Tree.","volume":"107","author":"H Shah","year":"1995 Jun","journal-title":"Chest."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"647-653","DOI":"10.1016\/j.rmr.2010.12.006","article-title":"Clinical characteristics of resected bronchial hamartoma. Study of seven cases.","volume":"28","author":"A Zehani-Kassar","year":"2011 May","journal-title":"Rev. Mal. Respir."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e21-e23","DOI":"10.1016\/j.jpedsurg.2009.06.011","article-title":"Endobronchial chondroid hamartoma in an infant.","volume":"44","author":"V Jain","year":"2009 Sep","journal-title":"J. Pediatr. Surg."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"220-223","DOI":"10.1002\/gcc.2870120310","article-title":"Cytogenetic and histologic findings in 17 pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomyomas.","volume":"12","author":"J Fletcher","year":"1995 Mar","journal-title":"Genes Chromosomes Cancer."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"4232-4238","DOI":"10.1016\/j.radcr.2022.08.018","article-title":"Endobronchial hamartoma resected via bronchoscopy using high-frequency electrosurgical snare-Preoperative strategies using virtual bronchoscopy.","volume":"17","author":"M Suzuki","year":"2022 Nov","journal-title":"Radiol. Case Rep."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"801-805","DOI":"10.1016\/j.rmr.2013.04.015","article-title":"Endobronchial hamartochondroma.","volume":"30","author":"H Bouazra","year":"2013 Nov","journal-title":"Rev. Mal. Respir."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1644-1648","DOI":"10.21037\/apm-21-2273","article-title":"Clinical experience of transbronchoscopic laser ablation for central airway stenosis using a high-power diode laser-ten years\u2019 experience at a single institute.","volume":"11","author":"K Tanaka","year":"2022 May","journal-title":"Ann. Palliat. Med."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"202-205","DOI":"10.1378\/chest.122.1.202","article-title":"Endobronchial hamartoma.","volume":"122","author":"B Cos\u00edo","year":"2002 Jul","journal-title":"Chest."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"65-69","DOI":"10.2214\/ajr.138.1.65","article-title":"Fine-needle biopsy of hamartomas of the lung.","volume":"138","author":"W Sinner","year":"1982 Jan","journal-title":"AJR Am. J. Roentgenol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/14-76\/v2\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-76\/v2\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/14-76\/v2\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:40:24Z","timestamp":1763664024000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/14-76\/v2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,14]]},"references-count":11,"URL":"https:\/\/doi.org\/10.12688\/f1000research.159445.2","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.159445.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.189414.r430247","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.189414.r430252","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.189414.r424923","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.189414.r430252","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.189414.r424923","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.189414.r430247","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,14]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/14-76\/v2#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.175169.r383632, Selene Cuenca Peris, General University Hospital of Castellon, Castellon, 26 May 2025, version 1, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/14-76\/v1#referee-response-383632","order":0,"name":"referee-response-383632","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.189414.r424923, Paolo Scanagatta, Hospital Eugenio Morelli, Morelli, 29 Oct 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-76\/v2#referee-response-424923","order":1,"name":"referee-response-424923","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.189414.r430252, Akesh Thomas, Prisma Health Greenville Memorial Medical Campus Department of Psychiatry & Behavioral Medicine, Greenville, South Carolina, 13 Nov 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-76\/v2#referee-response-430252","order":2,"name":"referee-response-430252","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.189414.r430247, Ummi Nadira Daut, Universiti Putra Malaysia, Serdang, 14 Nov 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-76\/v2#referee-response-430247","order":3,"name":"referee-response-430247","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}