{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:37Z","timestamp":1772168917748,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.159480.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000}},{"DOI":"10.12688\/f1000research.159480.2","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000}}],"reference-count":9,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T00:00:00Z","timestamp":1748822400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>The splenic localization of hydatid cysts is extremely rare. A 50-year-old obese female who consults with a painful and febrile syndrome of the right hypochondrium. Abdominal ultrasound and a CT scan computed tomography revealed a complete situs inversus, a mass of the right hypochondrium measuring 152 mm with membrane detachment, and infiltration of the surrounding fat, evoking a type II complicated splenic hydatic cyst. The patient was operated on in an emergency via midline laparotomy. Exploration revealed situs inversus, an angiant cyst of the spleen. Exposition of the splenic pedicle is difficult. The samples were then infected. Total splenectomy was performed. The postoperative period was unproblematic, and the patient was discharged with antibiotic and antiparasitic treatment and habitual vaccination.<\/ns3:p>","DOI":"10.12688\/f1000research.159480.3","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:55:08Z","timestamp":1748865308000},"page":"1480","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: A giant ruptured splenic hydatic cyst in a patient with a complete situs inversus: Diagnostic challenge and intra-operative difficulties"],"prefix":"10.12688","volume":"13","author":[{"given":"Amina","family":"Chaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0716-3670","authenticated-orcid":false,"given":"Wael","family":"Boujelb\u00e8ne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin","family":"Chaabouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Ali","family":"Bahloul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Kardoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salah","family":"Boujelben","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,6,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"3406-3409","DOI":"10.1016\/j.radcr.2023.06.069","article-title":"A rare case of recurrent hydatid cyst of the spleen: A case report.","volume":"18","author":"A Hassan","year":"oct 2023","journal-title":"Radiol. Case Rep."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2022.104829","article-title":"A case of giant primary splenic hydatid cyst: Case report.","volume":"84","author":"S Singh","year":"d\u00e9c 2022 cit\u00e9 28 d\u00e9c 2023","journal-title":"Ann. Med. Surg."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"435-437","DOI":"10.1016\/j.ijscr.2012.12.019","article-title":"Giant solitary hydatid cyst of spleen\u2014A case report.","volume":"4","author":"M Pukar","year":"2013","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2013.14.92.2343","article-title":"Kyste hydatique de la rate: \u00e0 propos d\u2019un cas.","volume":"14","author":"T Oumar","year":"2013 cit\u00e9 28 d\u00e9c 2023","journal-title":"Pan Afr. Med. J."},{"key":"ref5","article-title":"Kystes hydatiques de la rate: chirurgie radicale ou conservatrice?","author":"A Ousadden"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"15-19","DOI":"10.25122\/jml-2021-0221","article-title":"Splenic-preserving surgery in hydatid spleen: a single institutional experience.","volume":"15","author":"S Al-Hakkak","year":"janv 2022","journal-title":"J. Med. Life."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12893-020-01036-8","article-title":"Primitive isolated hydatid cyst of the spleen: total splenectomy versus spleen saving surgical modalities.","volume":"21","author":"A Mejri","year":"2021","journal-title":"BMC Surg. d\u00e9c."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"130-133","DOI":"10.5152\/UCD.2015.2947","article-title":"Unusually located primary hydatid cysts.","volume":"32","author":"N Aksakal","year":"14 juin 2016","journal-title":"Turk. J. Surg."},{"key":"ref9","first-page":"449","article-title":"Very Prolonged Treatment with Albendazole of a Case of Disseminated Abdominal Cystic Echinococcosis.","volume":"8","author":"C Buscemi","year":"15 sept 2023 cit\u00e9 7 janv 2025","journal-title":"Trop. Med. Infect. Dis [Internet]."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:55:09Z","timestamp":1748865309000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,2]]},"references-count":9,"URL":"https:\/\/doi.org\/10.12688\/f1000research.159480.3","relation":{"has-version":[{"id-type":"doi","id":"10.12688\/f1000research.159480.2","asserted-by":"subject"},{"id-type":"doi","id":"10.12688\/f1000research.159480.1","asserted-by":"subject"}],"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.183133.r389324","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,2]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.175212.r349375, Selmy Awad, Mansoura University Hospitals, El-Gomhouria Street, El-Mansoura, 28 Dec 2024, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v1#referee-response-349375","order":0,"name":"referee-response-349375","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Wael Boujelb&egrave;ne<\/b>; \n<i>Posted: 07 Jan 2025<\/i>; Dear Dr. Selmy Awad: Thank you for your valuable feedback on the case report. I appreciate your thoughtful insights and constructive criticism. 1. Typos and Grammar Mistakes: We acknowledge that there were some typos and grammatical errors in the manuscript. These will be carefully reviewed and corrected to ensure clarity and professionalism in the final version. 2. Role of Medical Treatment in Preoperative and Postoperative Regimens: You have raised an important point regarding the role of medical treatment in both preoperative preparation and postoperative regimens. We will include a more comprehensive discussion on the medical management, emphasizing its significance in patient preparation before surgery, as well as in the postoperative care to enhance recovery and prevent complications. 3. Standards for Writing Case Reports: We will ensure that the case report is fully aligned with the standards for writing case reports. This will involve revising the structure and adding any missing sections to enhance the clarity and scientific rigor. 4. Importance of Findings and Relevance to Disease Understanding: We appreciate your observation about the lack of a detailed discussion regarding the importance of the findings and their relevance to future disease understanding. We will expand this section to explain the significance of the case in relation to broader disease processes, diagnosis, and treatment. This will help contextualize the findings for future research and clinical practice. 5. Sufficiency of Details for Other Practitioners: We will review the report to ensure that enough practical insights and relevant details are provided for it to be a useful reference for others in the field. Thank you again for your review. We will address these concerns thoroughly in the revised version of the manuscript.","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3#referee-comment-13095","order":1,"name":"referee-comment-13095","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.175212.r349374, Silvio Buscemi, AOU Policlinico \"P. Giaccone\", Policlinico University Hospital, University of Palermo, Palermo, 07 Jan 2025, version 1, 1 approved, 1 approved with reservations","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v1#referee-response-349374","order":2,"name":"referee-response-349374","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Wael Boujelb&egrave;ne<\/b>; \n<i>Posted: 07 Jan 2025<\/i>; Dear Dr. Silvio Buscemi, Thank you for your insightful comments and positive feedback regarding our case report. We appreciate your valuable suggestions, which have significantly improved the quality of our work. Please find our responses to your considerations below: \n<b>1. Discussion of cystic echinococcosis in females with obesity<\/b> In the surgical treatment of abdominal cystic echinococcosis, obesity can complicate operative exposure due to increased intra-abdominal fat, making visualization and access to the surgical field more challenging. This raises the risk of spillage or injury to adjacent structures and may prolong operative time. Obesity-related comorbidities can further increase perioperative risks, highlighting the need for careful preoperative planning and surgical expertise. 2.&nbsp;\n<b>Inclusion of descriptive arrows in CT images<\/b> We acknowledge the importance of providing clear visual guidance in the CT images. Descriptive arrows have been added to highlight key findings, especially given the unique presentation of situs inversus. 3.&nbsp;\n<b>Details of the antiparasitic treatment regimen<\/b> We have expanded the description of the antiparasitic treatment regimen, specifying the protocol followed, including dosages, treatment duration, and intervals. This addition highlights the importance of continuing medical therapy after cyst rupture to prevent dissemination and recurrence. 4.&nbsp;\n<b>Documentation of antibody titers and blood chemistry changes<\/b> We have included detailed data on the evolution of antibody titers and blood chemistry tests post-surgery and during therapy. These additions are presented in &nbsp;the results sections to provide a comprehensive view of disease progression and response to treatment. 5.&nbsp;\n<b>References<\/b> We have incorporated your suggested reference to complement our discussion and to underline the importance of prolonged treatment with albendazole in managing disseminated cystic echinococcosis. 6.\n<b>Additional improvements<\/b> We have ensured that the background, physical examination findings, diagnostic tests, and treatment outcomes are presented in greater detail. The discussion has also been expanded to highlight the importance of our findings for future understanding and management of similar cases.We hope these revisions address your comments and enhance the quality and utility of our case report for other practitioners. Thank you for your time, expertise, and valuable feedback. Sincerely,","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v3#referee-comment-13094","order":3,"name":"referee-comment-13094","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.176728.r371891, Ali Bilal Ulas, Ataturk University, Erzurum, 22 Mar 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1480\/v2#referee-response-371891","order":4,"name":"referee-response-371891","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":5,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}