{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T23:49:17Z","timestamp":1775519357910,"version":"3.50.1"},"reference-count":78,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Social pain is emotional distress caused by harm or threat to social connections that results in social exclusion, rejection, or loss. Social Pain is also a potentiator of physical pain. Supportive social relationships are widely recognized for their impact on maintaining health and well-being. The Passion of Jesus Christ serves as a quintessential example of social pain (i.e., desertion, betrayal, denial) potentiating physical pain (i.e., beatings, Crown of Thorns, crucifixion). Christ opts to forgive. Although forgiveness is one solution to reduce social pain, other interventions exist. This review seeks to identify and summarize interventions associated with reducing social pain. We conducted a systematic review using Medline (PubMed), Google Scholar, and Cochrane CENTRAL to identify relevant articles. Results: The database searches produced 548 articles. Fourteen randomized controlled trials (RCTs) were included in this systematic review. Acetaminophen, both deceptive and open-label placebos, mindfulness training, and psilocybin were found to reduce social pain. Of note, the combination of acetaminophen and forgiveness yielded superior results compared to either acetaminophen or forgiveness alone. Pharmacological interventions operate on the premise that the neural pathways responsible for physical pain also play a role in social pain. Both pharmacological and non-pharmacological interventions are available for reducing social pain.<\/ns3:p>","DOI":"10.12688\/f1000research.159561.1","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T05:25:08Z","timestamp":1736486708000},"page":"58","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Social pain: A systematic review on interventions"],"prefix":"10.12688","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-3724","authenticated-orcid":false,"given":"Brandon M.","family":"Brooks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J.","family":"Cordero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen L.","family":"Alchermes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-4403","authenticated-orcid":false,"given":"Bradley M.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"107-122","DOI":"10.1177\/1524838016637079","article-title":"Forgiveness Therapy for the Promotion of Mental Well-Being: A Systematic Review and Meta-Analysis.","volume":"19","author":"S Akhtar","year":"2016","journal-title":"Trauma Violence Abuse."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"316-321","DOI":"10.1037\/a0019719","article-title":"Acute Effects of Intranasal Oxytocin on Subjective and Behavioral Responses to Social Rejection.","volume":"18","author":"G Alvares","year":"2010","journal-title":"Exp. 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