{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:36:05Z","timestamp":1781786165644,"version":"3.54.5"},"reference-count":6,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T00:00:00Z","timestamp":1733443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns4:p>This correspondence discusses the recent findings by Straalen et al., highlighting molecular similarities and distinctions between palmoplantar pustulosis (PPP) and dyshidrotic palmoplantar eczema (DPE). The study emphasizes shared proinflammatory pathways and T-cell\u2013related gene upregulation while detailing unique features such as neutrophil involvement in PPP and lipid antigen processing in DPE. We elaborate on histopathological differences, especially intraepidermal vesicle formation in PPP linked to IL\u20131\u2013mediated pathways and the absence of hyaluronan expression, contrasting with Th2 cytokines-driven spongiosis in DPE. By addressing IL-4, hyaluronan synthases, and keratinocyte adhesion molecules, this correspondence aims to deepen understanding of PPP and DPE pathophysiology.<\/ns4:p>","DOI":"10.12688\/f1000research.159565.1","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T05:00:12Z","timestamp":1733461212000},"page":"1494","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comments about the comparative bulk RNA sequencing between palmoplantar pustulosis and dyshidrotic palmoplantar eczema"],"prefix":"10.12688","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7747-0551","authenticated-orcid":false,"given":"Kazuki","family":"Yatsuzuka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Muto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamoto","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2024,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1204-1215.e9","DOI":"10.1016\/j.jaci.2024.07.017","article-title":"Disease heterogeneity and molecular classification of inflammatory palmoplantar diseases.","volume":"154","author":"K Straalen","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"13-19","DOI":"10.1016\/j.jdermsci.2020.03.003","article-title":"Palmoplantar pustulosis: Current understanding of disease definition and pathomechanism.","volume":"98","author":"M Murakami","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41598-023-50875-x","article-title":"A fluorescence imaging technique suggests that sweat leakage in the epidermis contributes to the pathomechanism of palmoplantar pustulosis.","volume":"14","author":"K Yatsuzuka","year":"2024","journal-title":"Sci. Rep."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1412-1420","DOI":"10.1038\/jid.2008.394","article-title":"Increased hyaluronan production and decreased E-cadherin expression by cytokine-stimulated keratinocytes lead to spongiosis formation.","volume":"129","author":"T Ohtani","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1325-1327","DOI":"10.1111\/bjd.18261","article-title":"Pompholyx vesicles contain small clusters of cells with high levels of hyaluronate resembling the pustulovesicles of palmoplantar pustulosis.","volume":"181","author":"M Murakami","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"399-408","DOI":"10.1111\/1346-8138.14850","article-title":"Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx.","volume":"46","author":"K Masuda-Kuroki","year":"2019","journal-title":"J. Dermatol."}],"container-title":["F1000Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1\/iparadigms","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T03:35:12Z","timestamp":1736825712000},"score":1,"resource":{"primary":{"URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,6]]},"references-count":6,"URL":"https:\/\/doi.org\/10.12688\/f1000research.159565.1","relation":{"has-review":[{"id-type":"doi","id":"10.5256\/f1000research.175314.r352002","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.175314.r352003","asserted-by":"subject"},{"id-type":"doi","id":"10.5256\/f1000research.175314.r352003","asserted-by":"object"},{"id-type":"doi","id":"10.5256\/f1000research.175314.r352002","asserted-by":"object"}]},"ISSN":["2046-1402"],"issn-type":[{"value":"2046-1402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,6]]},"assertion":[{"value":"Indexed","URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1#article-reports","order":0,"name":"referee-status","label":"Referee status","group":{"name":"current-referee-status","label":"Current Referee Status"}},{"value":"10.5256\/f1000research.175314.r352002, Yulong Sun, Huijuan Li, Northwestern Polytechnical University, Xi'an, Shaanxi, 07 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1#referee-response-352002","order":0,"name":"referee-response-352002","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kazuki Yatsuzuka<\/b>; \n<i>Posted: 13 Jan 2025<\/i>; Thank you for taking your valuable time to review our paper.  Sincerely,  Kazuki Yatsuzuka","URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1#referee-comment-13135","order":1,"name":"referee-comment-13135","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.175314.r352003, Sueli Carneiro, Federal University of Rio de Janeiro, RJ, 13 Jan 2025, version 1, indexed","URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1#referee-response-352003","order":2,"name":"referee-response-352003","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Kazuki Yatsuzuka<\/b>; \n<i>Posted: 13 Jan 2025<\/i>; Thank you for taking your valuable time to review our paper.  Sincerely,  Kazuki Yatsuzuka","URL":"https:\/\/f1000research.com\/articles\/13-1494\/v1#referee-comment-13136","order":3,"name":"referee-comment-13136","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}