{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:23:53Z","timestamp":1791973433056,"version":"4.3.4"},"reference-count":105,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:00:00Z","timestamp":1562630400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>Bleeding with resultant hemophilic arthropathy constitutes the largest cause of morbidity in patients with hemophilia. It results from repeated bleeding episodes in the joint and is characterized by synovial hypertrophy and cartilage and bony destruction. Hemophilic arthropathy assessment is a continually evolving process and is particularly challenging in children and young adults in whom joint disease may be missed or underestimated as obtaining serial \u201cbaseline\u201d magnetic resonance imaging scans of multiple clinically asymptomatic or nearly asymptomatic joints may be unjustifiable and cost-ineffective. Musculoskeletal ultrasound\u2014particularly, point-of-care musculoskeletal ultrasound\u2014has emerged as a promising imaging modality for the early detection and management of hemophilic arthropathy, and for the evaluation of hemarthrosis and painful musculoskeletal episodes in patients with hemophilia. This review summarizes currently available data on the emerging role of this new imaging modality, its limitations, and gaps in knowledge. The review also raises unanswered questions, highlights the need for consolidated research efforts, and delineates future directions expected to advance this technology and optimize its use in this patient population.<\/ns3:p>","DOI":"10.12688\/f1000research.16039.1","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T09:40:13Z","timestamp":1666950013000},"page":"1029","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Merging into the mainstream: the evolution of the role of point-of-care musculoskeletal ultrasound in hemophilia"],"prefix":"10.12688","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-8166","authenticated-orcid":false,"given":"Nihal","family":"Bakeer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3370-8166","authenticated-orcid":false,"given":"Amy D","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2560","published-online":{"date-parts":[[2019,7,9]]},"reference":[{"key":"ref-1","doi-asserted-by":"publisher","first-page":"10-9","DOI":"10.1053\/j.seminhematol.2015.10.005","article-title":"Advances and challenges in hemophilic arthropathy.","volume":"53","author":"T Wyseure","year":"2016","journal-title":"Semin Hematol."},{"key":"ref-2","doi-asserted-by":"publisher","first-page":"535-44","DOI":"10.1056\/NEJMoa067659","article-title":"Prophylaxis versus episodic treatment to prevent joint disease in boys with severe hemophilia.","volume":"357","author":"M Manco-Johnson","year":"2007","journal-title":"N Engl J Med."},{"key":"ref-3","doi-asserted-by":"publisher","first-page":"3073-81","DOI":"10.1182\/blood-2015-10-675140","article-title":"Men with severe hemophilia in the United States: birth cohort analysis of a large national database.","volume":"127","author":"M Mazepa","year":"2016","journal-title":"Blood."},{"key":"ref-4","first-page":"362-8","article-title":"New challenges in hemophilia: long-term outcomes and complications.","volume":"2012","author":"G Young","year":"2012","journal-title":"Hematology Am Soc Hematol Educ Program."},{"key":"ref-5","doi-asserted-by":"publisher","first-page":"729-37","DOI":"10.1111\/j.1365-2516.2012.02847.x","article-title":"Haemophilia care in Europe: the ESCHQoL study.","volume":"18","author":"W Schramm","year":"2012","journal-title":"Haemophilia."},{"key":"ref-6","doi-asserted-by":"publisher","first-page":"18-29","DOI":"10.1055\/s-0035-1568877","article-title":"Changing Paradigm of Hemophilia Management: Extended Half-Life Factor Concentrates and Gene Therapy.","volume":"42","author":"R Kumar","year":"2016","journal-title":"Semin Thromb Hemost."},{"key":"ref-7","doi-asserted-by":"publisher","first-page":"489","DOI":"10.12688\/f1000research.12491.1","article-title":"Emerging therapies for hemophilia: controversies and unanswered questions [version 1; 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