{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T05:08:55Z","timestamp":1772168935601,"version":"3.50.1"},"update-to":[{"DOI":"10.12688\/f1000research.160390.1","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000}}],"reference-count":103,"publisher":"F1000 Research Ltd","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["f1000research.com"],"crossmark-restriction":false},"short-container-title":["F1000Res"],"abstract":"<ns3:p>\n                    Background Studies assessing sub-maximal aerobic capacity in non-cirrhotic chronic hepatitis B (CHB) patients are scarce. This study aimed to evaluate sub-maximal aerobic capacity in CHB patients compared to apparently healthy participants (control-group (CG)). Methods A 6-min walk test (6MWT) was performed. The 6-min walk distance (6MWD) was recorded, along with heart-rate (HR), oxy-hemoglobin saturation (SpO\n                    <ns3:sub>2<\/ns3:sub>\n                    ), blood-pressure, and dyspnea (\n                    <ns3:bold>\n                      <ns3:italic>ie<\/ns3:italic>\n                    <\/ns3:bold>\n                    ; visual analogue scale) at rest (Rest) and at the end (End) of the 6MWT. Additionally, the 6-min walk work (6MWW), and \u0093estimated cardiorespiratory and muscular chain age\u0094 were calculated. Signs of physical intolerance were determined including abnormal 6MWD (\n                    <ns3:bold>\n                      <ns3:italic>ie<\/ns3:italic>\n                    <\/ns3:bold>\n                    ; 6MWD &lt; lower limit of normal), chronotropic insufficiency (ie ; HREnd &lt; 60% of maximal predicted HR (MPHR)), high dyspnea (\n                    <ns3:bold>\n                      <ns3:italic>ie<\/ns3:italic>\n                    <\/ns3:bold>\n                    ; dyspneaEnd &gt; 5), and desaturation (\n                    <ns3:bold>\n                      <ns3:italic>ie<\/ns3:italic>\n                    <\/ns3:bold>\n                    ; drop in SpO\n                    <ns3:sub>2<\/ns3:sub>\n                    &gt; 5 points). Results Compared to the CG (n=28), the CHB-group (n=26) exhibited significantly lower 6MWD by 61 meters (8%), lower 6MWW by 10%, and lower HR\n                    <ns3:sub>End<\/ns3:sub>\n                    by 21% (when expressed in bpm) and 17% (when expressed in %MPHR). The CHB-group, compared to the CG, included higher percentages of participants with chronotropic insufficiency and abnormal 6MWD (23.08% vs. 3.57%, and 34.61% vs. 3.57%, respectively). The CHB-group was 8.1 and 14.3 times more likely to have chronotropic insufficiency and abnormal 6MWD than the CG, respectively. CHB accelerated the aging of the \u0093cardiorespiratory and muscular chain\u0094 by 11 years. Conclusion Non-cirrhotic CHB may contribute to reduced submaximal aerobic capacity and acceleration of \u0093cardiorespiratory and muscular chain\u0094 aging.\n                  <\/ns3:p>","DOI":"10.12688\/f1000research.160390.2","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T11:45:18Z","timestamp":1744112718000},"page":"98","update-policy":"https:\/\/doi.org\/10.12688\/f1000research.crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of sub-maximal aerobic capacity in North African patients with chronic hepatitis B: a pilot case-control study"],"prefix":"10.12688","volume":"14","author":[{"given":"Jihene","family":"Bergaoui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imed","family":"Latiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sawssen","family":"MRAD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Chaouch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma","family":"Amous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihene","family":"Ben Abdallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samia","family":"Ernez Hajri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7477-2965","authenticated-orcid":false,"given":"Helmi","family":"Ben Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2560","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"ref1","first-page":"349-400","article-title":"Fulminant hepatic failure.","volume":"69","author":"P Berk","year":"1978 Mar","journal-title":"Am. 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We are truly grateful for your \n<b>thoughtful comments and constructive feedback<\/b> throughout the review process, which have greatly contributed to improving the quality and clarity of our manuscript. Your recognition of the \n<b>potential contribution<\/b> of our study to the understanding of liver disease, particularly viral hepatitis during exercise, is \n<b>deeply appreciated<\/b>. \n<b>Thank you<\/b> once again for your valuable input and for supporting the \n<b>acceptance of our revised manuscript<\/b>. With kind regards, Pr. Helmi Ben Saad","URL":"https:\/\/f1000research.com\/articles\/14-98\/v2#referee-comment-13743","order":1,"name":"referee-comment-13743","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"10.5256\/f1000research.179982.r376729, Kaouther MASMOUDI, University of Sfax, Sfax, 23 Apr 2025, version 2, indexed","URL":"https:\/\/f1000research.com\/articles\/14-98\/v2#referee-response-376729","order":2,"name":"referee-response-376729","label":"Referee Report","group":{"name":"article-reports","label":"Article Reports"}},{"value":"<b>Helmi BEN SAAD<\/b>; \n<i>Posted: 23 Apr 2025<\/i>; Dear Reviewer, I want to express my\n<b> sincere gratitude<\/b> on behalf of all the authors for your \n<b>nice remarks<\/b> and your \n<b>favorable evaluation<\/b> of our work. We sincerely appreciate your insightful remarks and \n<b>helpful criticism<\/b> during the review process, which have significantly raised the caliber and readability of our work. Once again, we appreciate your \n<b>insightful comments<\/b> and your\n<b> support<\/b> in getting our updated paper accepted. Pr. Helmi Ben Saad","URL":"https:\/\/f1000research.com\/articles\/14-98\/v2#referee-comment-13789","order":3,"name":"referee-comment-13789","label":"Referee Comment","group":{"name":"article-reports","label":"Article Reports"}},{"value":"The author(s) declared that no grants were involved in supporting this work","order":4,"name":"grant-information","label":"Grant Information"},{"value":"This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","order":0,"name":"copyright-info","label":"Copyright"}]}}